Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injuries
Improving Ventilatory Capacity in Those With Chronic High Level SCI
The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.
- Trial name
- NCT05041322
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Spaulding Rehabilitation Hospital
SCI - Spinal Cord Injury
Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI
This randomized clinical trial (RCT) is evaluating the usefulness of combining MyoMo robotic orthosis with visual and haptic feedback in ameliorating wrist/hand/UE movement capability, and increasing ADL and quality of life in…
- Trial name
- NCT05386537
- Testing
- MyoMo orthosis and VR games, MyoPro robot only, Games only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Tetraplegia/Tetraparesis, Quadriplegia
VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration
The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- NCT07224256
- Testing
- N1 Implant, R1 Robot
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Neuralink Corp
Spinal Cord Injury
Serotonergic Modulation of Motor Function in Subacute and Chronic SCI
The manifestation of weakness and involuntary reflexes following motor incomplete spinal cord injury (SCI) may be partly a result of damage to descending pathways to the spinal cord that release serotonin.
- Trial name
- NCT01788969
- Testing
- Lexapro
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
A Scar Recognition Software for Chronic Spinal Cord Injury (SCI)
To construct and validate a software to recognize scar for patients with chronic SCI based on multimodal MRI.
- Trial name
- NCT04955509
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Peking University Third Hospital
Myelomeningocele, Spinal Cord Injury
Reciprocating Gait Orthoses for Paraplegia Patients
Ambulation would bring many physiological and psychological benefits and getting up and walking has been a dream for paraplegia patients.The reciprocating gait orthoses (RGOs) for paraplegics particularly draws research…
- Conditions
- Myelomeningocele, Spinal Cord Injury, Spinal Muscular Atrophy
- Trial name
- UPGO (NCT02227407)
- Testing
- RGOs(reciprocating gait orthoses)
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spinal Cord Injuries (SCI), Detrusor Overactivity
The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury
The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female…
- Trial name
- NCT07578532
- Testing
- Transcutaneous Sacral Electrical Stimulation, Transcutaneous sacral magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injury
Testosterone and Long Pulse Stimulation After SCI
Denervation following spinal cord injury (SCI) limits beneficial application of neuromuscular electrical stimulation (NMES). SCI with denervation results in extensive muscle atrophy that is accompanied with several…
- Trial name
- NCT03345576
- Testing
- Testosterone and LPWS, Testosterone and standard NMES
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Repetitive Transcranial Magnetic Stimulation to Promote Regeneration in Persons With SCI
This is a research study to evaluate the safety, efficacy and feasibility of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in patients with subacute spinal cord injury.
- Trial name
- rTMS (NCT05333770)
- Testing
- High-frequency repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury, Bone Loss
12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)
The purpose of this study is to determine if a second year of exposure to teriparatide in both subjects that received a year of teriparatide or teriparatide-placebo will result in a greater increase in bone mass density (BMD)…
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02025179
- Testing
- Teriparatide, Vibration
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Spinal Cord Injuries (SCI)
Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation
Spinal cord stimulation (SCS) has been shown in previous studies to be capable of restoring motor and autonomic function in patients with chronic complete spinal cord injury (SCI).
- Trial name
- NCT07139496
- Testing
- Spinal Cord Stimulator
- Where
- Hong Kong
- Volunteers
- 5 people
- Sponsor
- The University of Hong Kong
Spinal Cord Injury Cervical
Restoration of Hand Function in Cervical SCI
The purpose of this study is to evaluate a new method of restoring hand function to people with spinal cord injury. Current methods to restore hand function include tendon transfers and nerve transfers.
- Trial name
- KeyGrip (NCT06611748)
- Testing
- Key Grip, Implanted Key Grip Electrodes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries
Vibration for Muscle Spasms After Spinal Cord Injury
This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in…
- Trial name
- NCT03598504
- Testing
- Wearable EMG/Vibration device
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
SCI - Spinal Cord Injury, Neuropathic Pain
Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI
The main purposes of this study are to (1) measure the effect of CBD/CBD-A on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperatures; and (2) measure the effect of CBD on brain…
- Trial name
- NCT05630235
- Testing
- CBD/CBD-A
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Spinal Cord Injury
Safety and Efficacy of Routine Colonoscopy Preparations
Periodic screening for colon cancer has become the standard of care in individuals over the age of 50. In this context, it is generally accepted that colonoscopy is the most sensitive modality for the detection of colon cancer…
- Trial name
- NCT00856440
- Testing
- Fleets Oral Sodium Phosphate Solution (OSPS), Colyte, Dual (OSPS & Colyte)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury
High Frequency SARS for Neurogenic Bladder and Bowel Emptying
The purpose of this study is to determine if bladder emptying can be achieved using stimulation of the sacral roots at certain frequencies. Neurogenic bladder dysfunction occurs after spinal cord injury (SCI).
- Trial name
- SARS600 (NCT05214378)
- Testing
- Finetech-Brindley Sacral Anterior Roots Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Orthostatic, Respiratory, Balance-Intervention
The purpose of this study is to help understand how training breathing muscles will impact balance, blood pressure, and quality of life of participants with spinal cord injury.
- Trial name
- ORB-I (NCT04210063)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Spinal Cord Injury, Neurogenic Bowel
Use of Prokinetics During Inpatient Bowel Care for SCI Patients
Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals…
- Trial name
- NCT02370433
- Testing
- Intravenous Neostigmine and Glycopyrrolate, Transdermal Neostigmine and Glycopyrrolate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Pressure Ulcer Prevention Study in SCI
The purpose of this study is to conduct a randomized controlled trial of a lifestyle redesign intervention's ability to (1)reduce the incidence of medically serious pressure ulcers and associated surgeries in adults with spinal…
- Trial name
- PUPS (NCT01999816)
- Testing
- Lifestyle Redesign
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- University of Southern California
Spinal Cord Injuries, Neuropathic Pain
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Degenerative Disc Disease, Spinal Stenosis
- Trial name
- NCT06438471
- Testing
- EC5026 oral tablet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- EicOsis Human Health Inc.