Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Spinal Cord Injury Patients
This is the FIH, multicenter, open-label, sequential, multiple ascending dose trial of NG004 in patients with acute incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- SPROUT (NCT06817577)
- Testing
- NG004
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 20 people
- Sponsor
- NovaGo Therapeutics AG
Spinal Cord Injury
Health and Financial Impact on the Use of a Personal Exoskeleton in the Home and Community: a Case Study
The goal of this clinical trial is to examine the long-term use of a personal overground robotic exoskeleton in subjects with spinal cord injury. The main aims of this study include: 1.
- Trial name
- NCT07030322
- Testing
- Overground Robotic Exoskeleton
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ekso Bionics
Spinal Cord Injuries
Mindfulness, Exercise and Nutrition To Optimize Resilience for Individuals With a Spinal Cord Injury.
The purpose of this study is to examine the effects of onsite and telehealth programs for individuals with spinal cord injury. The primary aim of this study is to compare the effectiveness of a blended 5-day onsite health…
- Trial name
- MENTOR (NCT03207737)
- Testing
- MENTOR + Telehealth, Telehealth Only
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries (SCI), Spinal Cord Injury
Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography
The aim of the study is to identify the specific characteristics of brain network dysfunctions and assess the recovery of their functionality through the recording of resting-state electroencephalography (EEG) during…
- Trial name
- NCT06725836
- Testing
- Implantation of electrodes into the epidural space for spinal cord stimulation, Selection of the optimal spinal cord stimulation program for spastic syndrome suppression, Selection of the optimal spinal cord stimulation program for volitional motor control
- Where
- 3 sites in Russia
- Volunteers
- 35 people
- Sponsor
- Artur Biktimirov
SCI - Spinal Cord Injury
tDCS and VI to Treat Neuropathic Pain and Function in SCI
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) will be applied for patient who suffer from neuropathic pain following spinal cord injury The tDCS treatment will be coupled with a video of a man…
- Trial name
- NCT03052244
- Testing
- tDCS+VI
- Volunteers
- 100 people
- Sponsor
- Loewenstein Hospital
Spinal Cord Injury
A Scar Recognition Software for Chronic Spinal Cord Injury (SCI)
To construct and validate a software to recognize scar for patients with chronic SCI based on multimodal MRI.
- Trial name
- NCT04955509
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Peking University Third Hospital
Spinal Cord Injury at T2 and Below
O2 Consumption and Heart Rate Response to Battle Rope Exercise Protocol Versus UE Arm Bike Test in Adults With SCI
The purpose of this study is to compare energy expenditure and metabolic outcomes of a novel seated battle rope protocol to seated maximal ramped upper extremity ergometry protocol in subjects with spinal cord injury.
- Trial name
- NCT03793595
- Testing
- Seated Battle Ropes Protocol, Seated Upper Extremity Arm Bike
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Spinal Cord Injury (SCI)
Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury
Background: Spinal cord injury (SCI) is a major global health problem, with thoraco-lumbar injuries often leading to paraplegia and incomplete neurological recovery.
- Trial name
- NCT07272967
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Badr University
Spinal Cord Injury, Pain
Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)
There has been little research on how chronic pain is related to brain activity. The purpose of this study is to learn more about pain and brain activity by finding any differences in brain activity among people who have moderate…
- Trial name
- NCT00947999
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Spinal Cord Injuries, Bowel Dysfunction
Noninvasive Spinal Cord Stimulation for Early SCI
The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as…
- Conditions
- Spinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic Dysfunction
- Trial name
- NCT06587841
- Testing
- Spinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Chronic Spinal Cord Injury
Abdominal Electrical Stimulation for Bowel Dysfunction in SCI
Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel.
- Trial name
- NCT06948175
- Testing
- Abdominal transcutaneous electrical stimulation (TES)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Spinal Cord, Metabolic Syndrome
Low Carbohydrate/High Protein Diet to Improve Metabolic Health
Individuals with spinal cord injury (SCI) are living to ages when metabolic disorders are highly prevalent. The combination of impaired glucose tolerance and insulin resistance can disrupt lipid metabolism and increase the risk…
- Conditions
- Spinal Cord, Metabolic Syndrome, Diabetes
- Trial name
- NCT03207841
- Testing
- LC/HP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injuries, Neuropathic Pain
Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain
The purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tDCS) on neuropathic pain symptoms and sensory functions in participants with spinal cord…
- Trial name
- NCT06010251
- Testing
- tDCS and bodily illusions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Spinal Cord Injuries (SCI)
Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI
he goal of this clinical trial is to learn if combined brain and spinal cord stimulation using TMS-tSCS can improve leg strength and walking recovery in adults with chronic incomplete spinal cord injury.
- Trial name
- NCT07595497
- Testing
- Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Spinal Cord Injury, Delayed Admission
Complications Associated With Delayed Admission to Spinal Injury Unit
The aim of this study is to determine the prevalence of complications including PUs at time of admission to a regional spinal injury rehabilitation unit (MCSI), the relationship between wait time to admission for specialist SCI…
- Trial name
- NCT07015099
- Where
- United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Spinal Cord Injuries, Spasticity, Muscle
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence.
- Conditions
- Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia
- Trial name
- NCT05432999
- Testing
- Extracorporeal Shockwave Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI
This study will utilize short duration and mild levels of reduced oxygen (hypoxia) to induce spinal plasticity while evaluating the appropriate timing schedule for this intervention, as well as, the effects of superimposing…
- Trial name
- NCT03774043
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab