Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injuries (SCI), Chronic Pain
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
The goal of this clinical trial is to learn whether virtual reality (VR)-based hypnotherapy, added to conventional physiotherapy, improves pain, sleep, mood, and quality of life in adults with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries (SCI), Chronic Pain, Neuropathic Pain, Sleep Disturbance
- Trial name
- HypnoVR-SCI (NCT07846410)
- Testing
- Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Spinal Cord Injuries, Central Pain Syndrome
Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI
Central neuropathic pain (CNP) is defined as chronic pain due to injury or disease in the central nervous system. This pain is most common among people with a spinal cord injuries (SCI), with a prevalence of about 50%.
- Trial name
- NCT03748290
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Spinal Cord Injury
Improving Bladder Function in SCI by Neuromodulation
This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.
- Trial name
- NCT02331979
- Testing
- Electromagnetic Neuromodulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Los Angeles
Spinal Cord Injuries
Transforming Research and Clinical Knowledge in Spinal Cord Injury
The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker…
- Trial name
- TRACK-SCI (NCT04565366)
- Where
- 5 sites in United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Spinal Cord Injury, Neurogenic Bowel
Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI
Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals…
- Trial name
- NCT02370862
- Testing
- Neostigmine and Glycopyrrolate
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Pressure Ulcer
Interactive Telehealth for Pressure Ulcer Prevention After SCI
The goal of this module project is to establish the efficacy of a portable sensor and app-based biofeedback technology system for promoting effective pressure relief behaviors and reducing risk of pressure ulcer development among…
- Trial name
- NCT03469141
- Testing
- Pressure Relief Monitoring System
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rancho Research Institute, Inc.
Spinal Cord Injury (SCI), Respiratory Complication
Effect of Resistive Inspiratory Muscle Training Optimizing Lung Function in Spinal Cord Injury
The goal of this clinical trial is to evaluate the effectiveness of resistive inspiratory muscle training (RIMT) in optimizing lung function in individuals with spinal cord injury (SCI).
- Trial name
- NCT06547606
- Testing
- Usual Care
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dhaka
Spinal Cord Injury
Autonomic Effects of Stimulation in SCI
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry.
- Trial name
- NCT05664646
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Stroke, Spinal Cord Injuries (SCI)
Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)
Rehabilitation remains important in the chronic phase after stroke or spinal cord injury, as meaningful improvements may still be achieved through intensive, goal-directed, and personalized training.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Chronic Disease
- Trial name
- INTeRAcT-bis (NCT07912320)
- Testing
- Intensive rehabilitation programme
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Spinal Cord Injury, Paralysis
A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes
The purpose of this study is to improve the performance of neuroprosthesis for standing after SCI by developing and testing new advanced methods that use multiple contact peripheral nerve electrodes to slow the onset of fatigue…
- Conditions
- Spinal Cord Injury, Paralysis, Tetraplegia, Paraplegia
- Trial name
- NCT01923662
- Testing
- IST-16 (16-Channel implanted stimulator-telemeter
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Acute Spinal Cord Injury, Blood Pressure
TSCS for Acute SCI
This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too…
- Conditions
- Acute Spinal Cord Injury, Blood Pressure, Hypotension
- Trial name
- NCT05305118
- Testing
- TSCS Mapping, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cervical Spinal Cord Injury
Rebuilding Inter-limb Transfer in Cervical SCI
The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic…
- Trial name
- NCT06440538
- Testing
- PCMS + Contralateral Motor Training, PCMS + Rest
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cervical Vertebrae Injury
Effectiveness of Robot-assisted Upper-limb Exercise in Cervical SCI
The aim of the project is to test the effectiveness of robot-assisted upper-limb exercise in persons after cervical spinal cord injury.
- Trial name
- RVZU (NCT06089915)
- Testing
- Standard occupational therapy, Robot-assisted exercise using Amadeo device and Armeo Spring exoskeleton
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Paraplegia, Quadriplegia
Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)
This proposal investigates the hypothesis that progressive aerobic exercise with Lokomat is feasible in people with motor incomplete spinal cord injury, and three months of training will improve cardiovascular fitness and gait…
- Conditions
- Paraplegia, Quadriplegia, Spinal Cord Injury, Tetraplegia
- Trial name
- NCT00385918
- Testing
- Lokomat Training, Home stretching then Lokomat training
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
SCI - Spinal Cord Injury, SCI
NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI
The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume…
- Conditions
- SCI - Spinal Cord Injury, SCI, Spinal Cord Injury
- Trial name
- NeuroRise (NCT07739043)
- Testing
- Human allogeneic, culture expanded, UC-MSC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cell Therapy LLC
Spinal Cord Injuries
Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury
The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with…
- Trial name
- NCT06514950
- Testing
- Ujjayi Yogic Breathing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Carbohydrate Study, Chronic SCI
As people with spinal cord injuries (SCI) get older they become more likely to develop health problems, just like everyone else. However, SCI increases the risk of certain problems.
- Trial name
- NCT00786435
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Spinal Cord Injury, Acquired Brain Injury
Safety and Usability of the STELO Exoskeleton in People With Acquired Brain Injury and Spinal Cord Injury
Gait impairment in people with acquired brain injury (ABI) and spinal cord injury (SCI) can be very heterogeneous. For this reason, STELO has been developed: a new concept of exoskeleton based on modular technology for gait…
- Trial name
- NCT05265377
- Testing
- Stelo
- Where
- 3 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Spinal Cord Injuries, Acute Traumatic Spinal Cord Injury
Spinal Decompression Plus Nerve Graft Implantation Following TSCI
This is a single-blinded (with outcome assessors blinded to treatment allocation), 12-month pilot study to evaluate of the safety, feasibility, and preliminary efficacy of dorsal myelotomy and expansive duraplasty performed…
- Trial name
- NCT06243211
- Testing
- DMED, ANGI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Francis Farhadi