Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injuries
Safety and Effectiveness of BM-MSC vs AT-MSC in the Treatment of SCI Patients.
Spinal Cord Injury (SCI) is a devastating condition that leads to permanent functional and neurological deficits in injured individuals.
- Trial name
- NCT02981576
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- Jordan
- Volunteers
- 14 people
- Sponsor
- University of Jordan
Spinal Cord Injury
Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation
Spinal cord injury (SCI) is a severe neurological condition characterized by the loss of motor and sensory functions due to damage in the spinal cord or the nerves branching from it.
- Trial name
- NCT07019207
- Testing
- VR-Based Dual-Task Training with Motor Imagery, VR-Based Dual-Task Training without Motor Imagery, Proprioceptive Neuromuscular Facilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University
Spinal Cord Injury Cervical
Restoration of Hand Function in Cervical SCI
The purpose of this study is to evaluate a new method of restoring hand function to people with spinal cord injury. Current methods to restore hand function include tendon transfers and nerve transfers.
- Trial name
- KeyGrip (NCT06611748)
- Testing
- Key Grip, Implanted Key Grip Electrodes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries
tSCS + UL Robotics Training in SCI Patients
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries.
- Trial name
- NCT07432321
- Testing
- ULRT + tSCS + conventional occupational therapy, ULRT + conventional occupational therapy
- Where
- Singapore
- Volunteers
- 6 people
- Sponsor
- National University Hospital, Singapore
Spinal Cord Injuries
Augmenting Reactive Stepping With FES After SCI
Up to 25 individuals living with chronic incomplete spinal cord injury (iSCI) who can stand but have limited ability to elicit a step without physical assistance or upper limb (U/L) support will be recruited for this study.
- Trial name
- NCT04309448
- Testing
- Perturbation-based balance training with functional electrical stimulation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
Spinal Cord Injury
FES Rowing for Skeletal Health After SCI
Following a complete spinal cord injury (SCI), individuals experience progressive bone loss, especially in the legs, with up to 70% of persons with SCI sustaining a fracture at some point during their lifetime.
- Trial name
- FES-R (NCT02008149)
- Testing
- Rowing exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Palliative Strategies in Spinal Cord Injury (SCI)
Spinal cord injury (SCI) leads to muscle atrophy, hyperreflexia and spasticity, symptoms that decrease quality of life and prevent effective rehabilitation.
- Trial name
- NCT00594178
- Testing
- Motorized bicycle exercise training
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Spinal Cord Injury, Vitamin D Deficiency
Vitamin D Deficiency and Replacement on Pulmonary and Endocrine Function in SCI
Studies have shown that individuals who have suffered a spinal cord injury are at an increased risk of Vitamin D deficiency compared to able-bodied individuals.
- Trial name
- NCT02099955
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Bridge Reinvention
The goal of this randomized controlled trial is to determine the efficacy of a treatment to improve resilience to stress for individuals with SCI who are transitioning from inpatient rehabilitation to home.
- Trial name
- NCT03554733
- Testing
- ReInventing Yourself after SCI
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Spinal Cord Injury
Xo-Motion R Exoskeleton in SCI-Adoption Study
After spinal cord injury (SCI), many people lose their ability to walk and do not have access to equipment and assistance that could help them regain functional abilities.
- Trial name
- NCT07380516
- Testing
- XoMotionR- assisted locomotor training
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Injuries, Spinal Cord, Neurogenic Bowel
Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI)
This study will look at the use of a telehealth version of a self management program in individuals with both new onset and chronic traumatic spinal cord injuries. The program is called Health Mechanics.
- Conditions
- Injuries, Spinal Cord, Neurogenic Bowel, Urinary Bladder, Neurogenic
- Trial name
- NCT01920243
- Testing
- Health Mechanics Program
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Michigan
Spinal Cord Injuries
Health Interventions for Survivors and Primary Support Persons of Spinal Cord Injury
The overall objective of this project is to test the efficacy of an innovative multi-component intervention aimed at reducing the risk for adverse health outcomes among caregivers of older survivors with spinal cord injury or…
- Trial name
- SCI (NCT00148239)
- Testing
- Caregiver Only Intervention, Dual Treatment, Control
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- University of Pittsburgh
Spinal Cord Injuries
Treatment of Spinal Cord Injuries With (AutoBM-MSCs)vs (WJ-MSCs).
This study aims to assess and compare the safety and effectiveness of Autologous Bone Marrow-Derived MSCs (AutoBM-MSCs) in one group(group A) of SCI who are unlikely to be able to walk independently without treatment after 1 year…
- Trial name
- NCT04288934
- Testing
- Collection and expansion of BM-MSC, VI-SCI evaluation and patients' follow up
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- University of Jordan
Cervical Spinal Cord Injury, Tetraplegia
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
- Trial name
- NCT06288763
- Where
- 10 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury
Developing a Home Telehealth Program to Manage Pressure Ulcers in SCI/D
The Veteran's Health Administration (VHA) is a national leader in using distance technology to monitor patients' self-care via an in-home messaging device with disease management protocols (DMPs).
- Trial name
- NCT00624806
- Testing
- Daily telephone calls, Weekly telephone calls
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Promoting the Psychological Health of Women With SCI: A Virtual World Intervention
The purpose of this project is to test the efficacy of an internet-based psychological health enhancement program for women with spinal cord injury.
- Trial name
- Zest (NCT03543111)
- Testing
- Zest
- Where
- 4 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries
FES Cycling and Nutritional Counseling for Battling Obesity After SCI
Individuals who suffer from paralysis after spinal cord injury (SCI) are estimated to have an even greater (66%) prevalence of obesity.
- Trial name
- NCT03810963
- Testing
- HIIT-FES Cycling combined with Nutritional Counseling, Nutritional Counseling Only
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- William Carey University
Spinal Cord Injuries
Remote Ischemic Conditioning for PwSCI
The long-term goal of this project is to improve the overall cardiometabolic health of persons with spinal cord injury (SCI). This pilot study will test the feasibility and acceptability of remote ischemic conditioning…
- Trial name
- NCT07488793
- Testing
- RIC high-dose standard blood pressure cuff, RIC high-dose automated blood flow restriction cuff, RIC low-dose standard blood pressure cuff
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury (SCI), Amyotrophic Lateral Sclerosis (ALS)
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
Most neurological injuries such as spinal cord injuries (SCI) and amyotrophic lateral sclerosis (ALS) spare a portion of nerve circuitry.
- Trial name
- NCT02469675
- Testing
- Transcranial magnetic stimulation, Median nerve stimulation, Cervical transcutaneous stimulation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Bronx VA Medical Center