Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injuries
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323945
- Testing
- AIH, Walk, Strength
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injuries (SCI), Neuropathic Pain Due to Spinal Cord Injury
Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI
About 70% of people with a spinal cord injury in Switzerland have chronic pain that lasts more than 3 to 6 months. This pain can be caused by muscle or joint problems, or by nerve damage (neuropathic pain).
- Trial name
- NCT07165353
- Testing
- Virtual Walking
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injury, Paraplegia
The Safety of ahSC in Chronic SCI With Rehabilitation
The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI.
- Conditions
- Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
- Trial name
- NCT02354625
- Testing
- Autologous human Schwann cells
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- W. Dalton Dietrich
Spinal Cord Injury
Transcutaneous Spinal Cord Stimulation With Robotic Gait Training in Chronic SCI
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment robotic gait training (RGT) to improve functional mobility in participants with chronic spinal cord injuries.
- Trial name
- NCT05921175
- Testing
- RGT+ tSCS + conventional physiotherap, RGT+ conventional physiotherapy
- Where
- Singapore
- Volunteers
- 6 people
- Sponsor
- National University Hospital, Singapore
Spinal Cord Injury
Spinal Cord Injury Registry - North American Clinical Trials Network
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time)…
- Trial name
- NACTN (NCT00178724)
- Testing
- No Treatment Given
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,500 people
- Sponsor
- Robert G. Grossman, MD
Spinal Cord Injury Cervical, Neuropathic Pain
PAS for Post-SCI Neuropathic Pain
The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles.
- Trial name
- NCT05362422
- Testing
- long-term paired associative stimulation
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Helsinki University Central Hospital
Autonomic Dysreflexia
Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI
The purpose of this study is to investigate the impact of 200 U intradetrusor injected OnabotulinumtoxinA (Botox®, Allergan, Inc.) (20 sites, trigone sparing) for neurogenic detrusor overactivity (NDO) and its role on reducing…
- Trial name
- NCT02298660
- Testing
- BOTOX
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Rick Hansen Institute
Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury
Powered Exoskeleton-Assisted Walking in Persons With Spinal Cord Injury
Spinal Cord Injury (SCI) represents a significant health challenge, particularly when it comes to the ability to walk. Among its many consequences, mobility impairment can not only directly impact quality of life but also cause a…
- Conditions
- Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury, Rehabilitation, Exoskeleton Device
- Trial name
- EKSO-SCI (NCT07884591)
- Testing
- Wearable Powered Exoskeleton
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- IRCCS San Raffaele Roma
Spinal Cord Injuries, Neurogenic Bladder
Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT
Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population.
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Bowel
- Trial name
- MACHINE (NCT04726059)
- Testing
- Transcutaneous Spinal Cord Stimulation, Activity-Based Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury
PROMPT-SCI (Protocol for Rapid Onset of Mobilization in Patients with Traumatic SCI) is a single-site single-arm proof-of-concept trial.
- Trial name
- PROMPT-SCI (NCT04699474)
- Testing
- Leg ergometer
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Traumatic Cervical Acute Spinal Cord Injury
Pilot Study of the Neuro-Spinal Scaffold for the Treatment of AIS A Cervical Acute SCI
Pilot Study of Clinical Safety and Feasibility of the Neuro-Spinal ScaffoldTM for the Treatment of Complete (AIS A) Traumatic Acute Spinal Cord Injury at the C5-T1 Neurological Levels The purpose of this study is to support an…
- Trial name
- NCT03105882
- Testing
- Neuro-Spinal Scaffold
- Where
- Canada
- Sponsor
- InVivo Therapeutics
Neurogenic Bladder, Urinary Retention
Connected Catheter - Safety and Effectiveness Study
The Connected Catheter is a fully internal, urethral indwelling urinary prosthesis designed for improved bladder management in males with urinary retention disorders requiring catheterization.
- Conditions
- Neurogenic Bladder, Urinary Retention, Urologic Diseases
- Trial name
- NCT04059159
- Testing
- Connected Catheter
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Spinal Singularity
Spinal Cord Injury
Neurofeedback for Treatment of Central Neuropathic Pain (CNP) in Sub-acute Spinal Cord Injury (SCI)
Spinal Cord Injury (SCI) affects a person's ability to move and feel sensation in the body. SCI is also an indirect cause of a persistent pain, called Central Neuropathic Pain (CNP).
- Trial name
- NCT02178917
- Testing
- Neurofeedback therapy, No neurofeedback therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injuries (SCI)
Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation
Spinal cord stimulation (SCS) has been shown in previous studies to be capable of restoring motor and autonomic function in patients with chronic complete spinal cord injury (SCI).
- Trial name
- NCT07139496
- Testing
- Spinal Cord Stimulator
- Where
- Hong Kong
- Volunteers
- 5 people
- Sponsor
- The University of Hong Kong
Spinal Cord Injuries
Nutrition Education Program in Spinal Cord Injury (SCI)
The purpose of this research is to assess the effectiveness of a nutrition education program in increasing nutrition knowledge and improving health-related biomarkers in individuals with spinal cord injury (SCI).
- Trial name
- NCT05953597
- Testing
- Nutrition Education
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Spinal Cord Injury
Bone Strength After Spinal Cord Injury
Background: After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk.
- Trial name
- NCT01853488
- Testing
- DXA, pQCT
- Where
- Switzerland
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathic Pain
Intrathecal Baclofen (ITB) Bolus on Neuropathic Pain (NP). Preliminary Study.
Hypothesis: ITB bolus can have antinociceptive effect on neuropathic pain in spinal cord injury patients, which could depend on the subtype of pain, or on the lesion level, cervical or thoracic spinal cord injury.
- Trial name
- ITB (NCT02705950)
- Testing
- Intrathecal baclofen bolus
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Institut Guttmann
Spinal Cord Injury (SCI)
Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
Acute Spinal Cord Injury (SCI) is a rare injury that leads to permanent neuromotor impairment and sudden disability. Approximately 25,000 people experience cervical SCI in the United States, Europe, and Japan every year.
- Trial name
- ELASCI (NCT04295538)
- Testing
- Elezanumab
- Where
- 41 sites in United States, Australia and 5 more
- Volunteers
- 60 people
- Sponsor
- AbbVie
Spinal Cord Injuries, Obesity
The SEEA (SCI Energy Expenditure and Activity) Study
People with SCI are at higher risk of obesity and chronic diseases, such as hypertension, high cholesterol, diabetes and cardiovascular disease, than the general population.
- Conditions
- Spinal Cord Injuries, Obesity, Metabolic Syndrome, Cardiovascular Diseases
- Trial name
- SEEA (NCT04748835)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injuries, Spine Disease
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe…
- Trial name
- NCT05473689
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto