Clinical trials: Spinal Cord Injury, Chronic
Spinal Cord Injuries, Spinal Injuries
DBS of PPN to Improve Walking in Chronic SCI Patients
Spinal cord injury (SCI) is a devastating condition affecting over 1 million individuals in North America. SCI often results in severe motor impairments with few available treatments options.
- Conditions
- Spinal Cord Injuries, Spinal Injuries, Spinal Fractures
- Trial name
- NCT04325165
- Testing
- DBS Implantation
- Sponsor
- University Health Network, Toronto
Spinal Cord Injury, Chronic Pain
Association Between Types of Pain and Motor Activities Physical Activity
This study will investigate the relationships between: (1) physical activity (PA) and types of chronic pain (nociceptive and neuropathic), and (2) virtual reality (VR) and types of chronic pain (nociceptive and neuropathic).
- Trial name
- NCT05236933
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Temple University
Spina Bifida, Cerebral Palsy
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them.
- Conditions
- Spina Bifida, Cerebral Palsy, Genetic Disease, Spinal Cord Injuries
- Trial name
- NCT05339932
- Testing
- Manual Wheelchair Skills Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Chronic Pain
Evaluation of Alexithymia in Chronic Pain Patients With Spinal Cord Stimulation
The purpose of this study is to investigate the relationship between alexithymia levels and clinical parameters, including pain intensity and quality of life, in chronic pain patients treated with spinal cord stimulation (SCS).
- Trial name
- NCT07696286
- Testing
- Psychometric Questionnaires and Retrospective Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Internet Delivered Treatment, Spinal Cord Injury
EmpowerSpine Program
Chronic pain affects over 60% of individuals living with spinal cord injuries (SCI), significantly impairing their daily lives and overall well-being.
- Conditions
- Internet Delivered Treatment, Spinal Cord Injury, Chronic Pain, Multidisciplinary Approach
- Trial name
- NCT07419646
- Testing
- EmpowerSpine, Guidance (G), Peer Support (PS)
- Volunteers
- 100 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Spinal Cord Injuries, Tetraplegia
Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)
This study will evaluate if Ursolic Acid supplementation may be effective in reducing muscle loss and improving blood sugar control in the SCI community.
- Conditions
- Spinal Cord Injuries, Tetraplegia, Paraplegia, Muscle Loss
- Trial name
- NCT05776862
- Testing
- Ursolic Acid, Strength Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Chronic Pain
The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain
Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce…
- Trial name
- NCT05741788
- Testing
- Various Stimulation Patterns
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with cervical chronic and complete spinal cord injury.
- Trial name
- NCT02574572
- Testing
- Autologous mesenchymal cells transplantation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Sao Rafael
Spinal Cord Injury, Pain Management
Solving SCI Pain: Pain Recovery Tools for SCI
Brief Summary The goal of this clinical trial is to evaluate whether a neuroscience-informed, peer-led self-management program can promote behavior change and reduce pain interference in adults with spinal cord injury (SCI) and…
- Conditions
- Spinal Cord Injury, Pain Management, Self-management Behaviors
- Trial name
- NCT07212725
- Testing
- Solving SCI Pain: Peer-Led Pain Self-Management Pain Tools Program
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Neuropathic Pain
To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.
To evaluate long-term safety and efficacy of pregabalin in the treatment of neuropathic pain after spinal cord injury.
- Trial name
- NCT00141375
- Testing
- Pregabalin
- Where
- 7 sites in Australia
- Volunteers
- 132 people
- Sponsor
- Pfizer
Electric Stimulation Therapy, Bowel Dysfunction
The Effect of NMES on Bowel Management in People With Chronic SCI
It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela.
- Conditions
- Electric Stimulation Therapy, Bowel Dysfunction, Spinal Cord Injuries, Defecation Disorder
- Trial name
- FES_Bowel (NCT04914975)
- Testing
- Neuromuscular electrical stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries
Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)
The purpose of this research is to test if Auricular Vagal Nerve Stimulation (aVNS) is safe in persons with spinal cord injury (SCI).
- Trial name
- NCT06588608
- Testing
- auricular nerve stimulation (aVNS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Miami
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Spinal Cord Injuries (SCI), Osteoporosis
Osteoporosis Awareness in Chronic Spinal Cord Injury
Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures.
- Conditions
- Spinal Cord Injuries (SCI), Osteoporosis, Health Knowledge, Attitudes
- Trial name
- NCT07725081
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injury
The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study
This study will enroll 10 adults with a chronic spinal cord injury. The investigators will image their damaged motor tracts using MRI tractography scanning, and the investigators will formally assess their ASIA motor level at the…
- Trial name
- NCT01904591
- Testing
- Selenium, Vitamin E
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McMaster University
Spinal Cord Injury, Chronic
taVNS During Exercise and Recovery in Chronic Spinal Cord Injury
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI).
- Trial name
- taVNS-HRV-SCI (NCT07524491)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- University of the Balearic Islands
Spinal Cord Injury Cervical, Spastic
Task Practice and Spinal Cord Stimulation
The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity.
- Trial name
- NCT06494020
- Testing
- Task Practice combined with Transcutaneous Spinal Cord Stimulation( TcSCS)
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Spinal Cord Injury
Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI
To determine the acute and chronic effects of a short course of treatment on spinal cord injured (SCI) individuals with either an anticholinergic agent (tiotropium) or with a β₂ agonist (Salmeterol) on: Fraction of expired NO…
- Trial name
- NCT01355991
- Testing
- Tiotropium, Salmeterol
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Neuropathic Pain, Depression
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders.
- Conditions
- Neuropathic Pain, Depression, Cognitive Impairment, Somatic Neuropathy
- Trial name
- NCT02099890
- Testing
- Omega-3, Vegetation Protein Powder, InflanNox
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brock University
Spinal Cord Injuries
Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention.
- Trial name
- NCT04379011
- Testing
- Brivaracetam
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota