Clinical trials: Spinal Cord Stimulation (SCS)
Chronic Pain Syndrome
Post-reimbursement Study to Follow Spinal Neurostimulator Devices for Pain Therapy (French SCS Registry)
Observational study to evaluate the long term efficacy of Spinal Cord Stimulation (SCS) over 2 years following SCS implant. This study is requested by French Health Authorities for reimbursement renewal, to maintain reimbursement…
- Trial name
- SME (NCT01778426)
- Where
- France
- Volunteers
- 414 people
- Sponsor
- MedtronicNeuro
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day
The goals of this study are to provide sensory information to amputees and reduce phantom limb pain via electrical stimulation of the lumbar spinal cord and spinal nerves.
- Trial name
- SCS-90 (NCT04547582)
- Testing
- Spinal cord stimulator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lee Fisher, PhD
Chronic Pain
Vectors Post Market: A Study to Assess Pain Relief Using Spinal Cord Stimulation
This is a prospective, single-arm, multi-center study evaluating the efficacy of spinal cord stimulation (SCS) therapy for pain relief using high dose (HD) stimulation parameters delivered to neural targets identified during…
- Trial name
- NCT03345472
- Testing
- Spinal Cord Stimulation System
- Where
- 20 sites in United States
- Volunteers
- 175 people
- Sponsor
- MedtronicNeuro
Chronic Neuropathic Pain in the Low Back and Legs
Field Shape and Amplitude Sensitivity Exploratory Study (CONTOUR Study)
The study aims to better understand how to program Spinal Cord Stimulation for the treatment of chronic low back and leg pain
- Trial name
- NCT02916498
- Testing
- Boston Scientific's Precision SPECTRA™ Spinal Cord Stimulation System
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Boston Scientific Corporation
Chronic Lower Limb Pain
A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
The purpose of this study is to evaluate the safety and effectiveness of the AXIUM Neurostimulator System for the treatment of chronic lower limb pain in persons diagnosed with Complex Regional Pain Syndrome (CRPS) or Peripheral…
- Trial name
- ACCURATE (NCT01923285)
- Testing
- AXIUM Neurostimulator System, Control Spinal Cord Stimulation Device
- Where
- 22 sites in United States
- Volunteers
- 152 people
- Sponsor
- Abbott Medical Devices
Painful Diabetic Neuropathy
Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation
Will participants with painful lower extremity diabetic peripheral neuropathy (DPN) that are treated with high frequency spinal cord stimulation (HF10 SCS) have improvements in lower extremity peripheral nerve function?
- Trial name
- NCT03769675
- Testing
- High Frequency Spinal Cord Stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Chronic Pain
SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery
To evaluate the safety and effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities compared to Conventional Medical Management (CMM) in patients with chronic low back and/or leg pain who have not undergone spinal…
- Trial name
- SOLIS (NCT04676022)
- Testing
- WaveWriter, Conventional Medical Managament
- Where
- 23 sites in United States
- Volunteers
- 241 people
- Sponsor
- Boston Scientific Corporation
Spinal Cord Injuries, Spinal Cord Diseases
Stimulation With Wire Leads to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation, using wire leads, to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT01659541
- Testing
- Expiratory muscle stimulator, Implantation of device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Hypertension
Spinal Cord Stimulation to Treat Hypertension
To investigate the exercise blood pressure response during a lower-extremity dynamic exercise in postmenopausal women with hypertension and to determine if lumbar epidural spinal cord stimulation reduces blood pressure during…
- Trial name
- NCT02828436
- Testing
- Precision Spectra System, Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Chronic Pain
Spinal Cord Stimulation Trial to Permanent Prediction
Spinal Cord Stimulation Trial to Permanent Prediction is a prospective, longitudinal, multi-center, non-randomized, multi-arm, open-label, clinical feasibility study designed to investigate whether objective data collected from…
- Trial name
- SCS T2P (NCT05659836)
- Testing
- Abbott Spinal Cord Stimulation (SCS) Systems (Apple Watch® & Oura™ Ring)
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Abbott Medical Devices
Chronic Pain
Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
The purpose of this prospective post market observational pilot study is to evaluate the effect of DRG stimulation in the management of chronic discogenic pain in subjects who are refractory to other available treatments.
- Trial name
- NCT02587637
- Testing
- Dorsal root ganglion (DRG) stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Transcutaneous Spinal Stimulation, Walking
Spinal Cord Stimulation to Augment Activity Based Therapy
Involuntary muscle activity, often called spasticity, is a common problem following spinal cord injury (SCI) that can make it hard to move.
- Conditions
- Transcutaneous Spinal Stimulation, Walking, Spasticity, Human
- Trial name
- NCT03240601
- Testing
- Transcutaneous spinal stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shepherd Center, Atlanta GA
Phantom Limb
Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Individuals with upper-limb amputation usually have intact nerves within the residual limb, and studies have demonstrated that electrical stimulation of those nerves can produce sensations that appear to emanate from the…
- Trial name
- PhantomLimb (NCT02684201)
- Testing
- Boston Scientific Stimulator Lead
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lee Fisher, PhD
Chronic Pain
Effect of Epidural Stimulation on Muscle Activation and Sensory Perception
Each year, an estimated 34,000 individuals undergo epidural spinal cord stimulation (SCS) surgery to address debilitating chronic low back and leg pain (CLBLP).
- Trial name
- NCT04157400
- Testing
- Intraoperative Parameter Testing, Proprioception Testing During Stimulation, Gait Analysis During Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Failed Back Surgery Syndrome, Back Pain
Spinal Cord Stimulation for Predominant Low Back Pain
The purpose of this study is to compare the effectiveness of spinal cord stimulation (SCS) using the Medtronic Specify® 5-6-5 multicolumn surgical lead plus optimal medical management (OMM) versus OMM alone in patients suffering…
- Conditions
- Failed Back Surgery Syndrome, Back Pain, Pain in Leg, Unspecified
- Trial name
- PROMISE (NCT01697358)
- Testing
- Spinal Cord Stimulation (SCS), Optimal Medical Management (OMM)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 278 people
- Sponsor
- MedtronicNeuro
Chronic Pain
Paresthesia-Free Fast-Acting Subperception (FAST) Study
Study to evaluate the effectiveness of FAST-SCS (fast-acting paresthesia-free therapy) and additional SCS therapy options in patients with chronic pain using Boston Scientific WaveWriter SCS Systems.
- Trial name
- FAST (NCT04618471)
- Testing
- Boston Scientific WaveWriter SCS System
- Where
- 13 sites in United States
- Volunteers
- 177 people
- Sponsor
- Boston Scientific Corporation
Stiff-Person Syndrome
Evaluating Spinal Cord Stimulation for Stiff Person Syndrome
The purpose of this prospective pilot study is to gather preliminary evidence evaluating spinal cord stimulation (SCS) as a potential therapy for the treatment of rigidity and painful spasms in patients with stiff person syndrome…
- Trial name
- NCT06242678
- Testing
- SCS trial lead
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Chronic Pain
High Rate Spinal Cord Stimulation (SCS) for Chronic Pain
To determine the effects of varying spinal cord stimulation programming parameters, including stimulation rate, on pain intensity.
- Trial name
- NCT01624740
- Testing
- Low Rate Stimulation, High Rate Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation