Clinical trials: Spinal Cord Stimulation (SCS)
Chronic Pain
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.
- Trial name
- Neural Panel (NCT06229470)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 25 sites in United States
- Volunteers
- 250 people
- Sponsor
- Saluda Medical Pty Ltd
Chronic Pain
Focal Pain Outcomes Using Configurations Applied for Lateral Stimulation
To evaluate programming modalities at various targets for focal foot, knee pain, and groin pain relief.
- Trial name
- FOCAL (NCT04073446)
- Testing
- Spinal Cord Stimulation
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- Boston Scientific Corporation
Spinal Cord Injuries, Spinal Cord Injury
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT06274021
- Testing
- Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Mississippi Medical Center
SCS, Chronic Pain
Paresthesia Free Spinal Cord Stimulation (PF-SCS)
The goal is to document efficacy of PF-SCS therapy in a blinded fashion and better understand how SCS therapy works in the clinical setting.
- Trial name
- NCT03670147
- Testing
- PF-SCS programming
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Spinal Cord Stimulation, Failed Back Surgery Syndrome
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation
Failed Back Surgery Syndrome (FBSS) is a relatively common condition that can cause a severe disability in patients. Spinal cord stimulation (SCS) is used in those patients refractory to conventional therapies.In this project the…
- Conditions
- Spinal Cord Stimulation, Failed Back Surgery Syndrome, Genetic Change
- Trial name
- SCS-OMICS (NCT05712980)
- Testing
- Implanted pulse generator for SCS with different programming modalities
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital General Universitario de Valencia
Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 4
Spinal Cord Stimulation in Spinal Muscular Atrophy
Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical…
- Trial name
- SCSinSMA (NCT05430113)
- Testing
- Spinal Cord Stimulator (octopolar Medtronic Vectris Leads)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Marco Capogrosso
Spinal Cord Injury
Autonomic Effects of Stimulation in SCI
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry.
- Trial name
- NCT05664646
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome
Effects of Active Versus Passive Recharge Burst Spinal Cord Stimulation on Pain Experience in Persistent Spinal Pain Syndrome Type 2: a Multicenter Randomized Trial (BURST-RAP Study)
Spinal cord stimulation (SCS) has shown to be an effective treatment for patients with persistent spinal pain syndrome Type 2 (PSPS Type 2). The method used to deliver electrical charge in SCS is important.
- Trial name
- BURST-RAP (NCT05421273)
- Testing
- Spinal cord stimulation using passive recharge burst stimulation, Spinal cord stimulation using active recharge burst stimulation
- Where
- 6 sites in Netherlands
- Volunteers
- 96 people
- Sponsor
- Rijnstate Hospital
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Chronic Pain, Chronic Low-back Pain
Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain
The Presidio Medical Ultra Low Frequency (ULF™) Spinal Cord Stimulation (SCS) System is intended to provide pain relief to participants who have been clinically diagnosed with chronic low back pain with or without leg pain.
- Trial name
- NCT05837234
- Testing
- ULF SCS
- Where
- 3 sites in Australia
- Volunteers
- 55 people
- Sponsor
- Presidio Medical, Inc
Progressive Supranuclear Palsy, Spinal Cord Stimulation
The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
The study is an open-label, prospective, single-arm, unicentral (Huashan Hospital Department of Neurology/ Neurosurgery) and exploratory clinical trial.
- Trial name
- NCT04367116
- Testing
- Spinal Cord Stimulation
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Huashan Hospital
Chronic Pain, Back Pain
ECAP-controlled, Closed-loop Stimulation to Treat Chronic Trunk and/or Limb Pain (ECAP)
The purpose of this study is to evaluate neurophysiological measures and clinical outcomes of the Evoke System to treat trunk and/or limb pain in a real-world population.
- Conditions
- Chronic Pain, Back Pain, Pain
- Trial name
- ECAP (NCT04319887)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 22 sites in United States
- Volunteers
- 300 people
- Sponsor
- Saluda Medical Pty Ltd
Mononeuropathies, Spinal Cord Stimulation
Spinal Cord Stimulation for Intractable Mononeuropathy
Rationale: For patients with mononeuropathy, literature has shown that spinal cord stimulation (SCS) is an effective therapy for patients who are therapy-resistant to more conventional treatments.
- Trial name
- SCIMONO (NCT06546371)
- Testing
- Spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Erasmus Medical Center
Painful Diabetic Peripheral Neuropathy
High-frequency SCS Versus SCS in the Treatment of Diabetic Peripheral Neuropathic Pain
Application of High-Frequency Spinal Cord Stimulation (HF-SCS) in the Treatment of Painful Diabetic Peripheral Neuropathy (PDPN): A multicenter, randomized controlled study comparing its clinical efficacy with traditional spinal…
- Trial name
- NCT06158529
- Testing
- spinal cord stimulator, high frequency spinal cord stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Fan BiFa
Parkinson Disease, Gait Disorders, Neurologic
Spinal Cord sTimulation thEraPy for Parkinson's Disease Patients With Gait Problems
Gait difficulties are common in Parkinson's disease (PD) and cause significant disability. No treatment is available for these symptoms.
- Conditions
- Parkinson Disease, Gait Disorders, Neurologic, Fall Injury
- Trial name
- STEP-PD (NCT05110053)
- Testing
- Spinal Cord Stimulation
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Pain, Low Back Pain
Changes in Cerebral Blood Flow in Patients Treated With Spinal Cord Stimulation for Low Back and Leg Pain
The primary objective of this study is to identify the brain regions in which activity is affected by SCS. Baseline cerebral blood flow scans with the device turned off will be generated compared to scans produced with the device…
- Conditions
- Pain, Low Back Pain, Leg Pain
- Trial name
- NCT00418301
- Testing
- Precision Spinal Cord Stimulation and PET Scan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Palliative Care
A Prospective, Open Label, Pilot Study of Patient OutcoMes Following Successful TriAl of High Frequency SpInal CorD Stimulation at 10kHz (HF10™) Leading to Permanent Implant Compared to Trial Failure and Standard CarE for the TreatmeNt of Persistent Low BACK Pain of Neuropathic Origin
25 participants with back pain and no previous spinal surgery will be enrolled from a single NHS site in England. Participants will have already discussed spinal cord stimulation (SCS) pain management with their consultant before…
- Trial name
- Maiden Back (NCT02689375)
- Testing
- Senza Spinal Cord Stimulation system
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training
Spinal Cord Injury (SCI) disrupts signals between the brain and the rest of the body, this includes signals needed to control the bladder and bowels.
- Trial name
- NCT05504200
- Testing
- Bladder and Pelvic Floor Muscle Training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- RNOH RIC
Spinal Cord Injury
Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs
This study is to determine if non-invasive electrical stimulation of the spinal cord can be used to: 1) assess spared function following a spinal cord injury; and 2) be use for rehabilitation.
- Trial name
- NCT01949285
- Testing
- Transcutaneous Electrical Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NeuroEnabling Technologies, Inc.
Heart Failure
Spinal Cord Stimulation in Heart Failure
Previous studies have shown that spinal cord stimulation (SCS) may improve cardiac output and decrease the risk of ischemic ventricular arrhythmia in animal model and its safety profile in human trial.
- Trial name
- NCT03060148
- Testing
- Medtronic neurostimulation system
- Volunteers
- 15 people
- Sponsor
- Chang Gung Memorial Hospital