Clinical trials: Spinal Decompression
Degenerative Lumbar Spondylolisthesis
Degenerative Spondylolisthesis; Micro-decompression vs Decompression + Instrumented Fusion; Long Term Follow up
In many countries a majority of patients with degenerative spondylolisthesis are operated on with decompression plus instrumented fusion, but the scientific evidence for adding fusion is controversial.
- Trial name
- DS-registry (NCT03469791)
- Testing
- Surgical treatment of Degenerative Spondylolisthesis
- Where
- Norway
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Spine Tumor, Spine Metastases
Spine Oncology Registry
This is an observational study to evaluate hardware related and oncologic outcomes in adult patients with primary and metastatic spine disease undergoing separation surgery followed by radiation treatment.
- Conditions
- Spine Tumor, Spine Metastases, Spine Cancer
- Trial name
- NCT07225491
- Where
- 5 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
PONV, Cerebellopontine Angle Tumor
Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery
This single-center, double-blind, randomized controlled trial aims to determine whether oliceridine for patient-controlled intravenous analgesia (PCIA) can significantly reduce the incidence of postoperative nausea, an…
- Conditions
- PONV, Cerebellopontine Angle Tumor, Microvascular Decompression Surgery, Postoperative Analgesia
- Trial name
- NCT07479446
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Stenosis Lumbar
Full-Endoscopic Decompression vs. Endoscopic Lumbar Fusion for Middle-Aged and Older Adults With Spinal Stenosis
Lumbar Spinal Stenosis (LSS) is a syndrome characterized by anatomical narrowing of the central canal, lateral recess, or intervertebral foramen of the lumbar spine, leading to compression of nerve roots, the cauda equina, and…
- Trial name
- NCT07482826
- Testing
- Full-Endoscopic Decompression, Endoscopic Lumbar Interbody Fusion
- Volunteers
- 176 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Spinal Stenosis
Changes in Motor Latency During Spinal Decompression: Relationship to Outcomes
Is there a relationship between changes in motor evoked potential latency intraoperatively and post-operative changes in walking function in patients undergoing spinal decompression.
- Trial name
- NCT02529943
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Saskatchewan
Lumbar Radiculopathy
Comparative Effects Of High Intensity Spinal Decompression Exercises And Eldoa In Patients Of Lumbar Radiculopathy
To compare the effects of high intensity spinal decompression exercises and Eldoa on pain, ROM and Disability in patients of lumbar radiculopathy.
- Trial name
- NCT06087107
- Testing
- High Intensity Spinal Decompression Exercises, Eldoa
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Spinal Stenosis, Ligamentum Flavum Hypertrophy
Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression
Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability.
- Trial name
- NCT07232836
- Testing
- Endoscopic Spinal Canal Decompression
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Physical Education
Lumbar Spinal Stenosis
MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study
This is a multi-center, prospective, observational clinical study to compare patient outcomes following treatment with either the mild® procedure or epidural steroid injection in patients with moderate to severe lumbar spinal…
- Trial name
- MiDAS III (NCT01315145)
- Testing
- Percutaneous Lumbar Decompression, Epidural Steroid Injection
- Where
- 27 sites in United States
- Volunteers
- 138 people
- Sponsor
- Vertos Medical, Inc.
Spinal Cord Injury, Acute Spinal Cord Injury (SCI)
Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn whether expansile duraplasty can improve neurological recovery in adult patients with acute severe traumatic spinal cord injury, as well as evaluate the safety of this surgical…
- Trial name
- GLAD (NCT07733401)
- Testing
- Expansile duraplasty
- Where
- 13 sites in China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Cord Injuries
Epidural Decompression Surgery Within 24 Hours After Acute Spinal Cord Injury Improves Spinal Nerve Function
To compare the effects of early (within 24 hours) and delayed (exceed 24 hours) epidural decompression surgery on the recovery of spinal nerve function in patients with acute spinal cord injury (complete and incomplete) at…
- Trial name
- NCT03103516
- Testing
- early epidural decompression group, delayed epidural decompression group
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Trigeminal Neuralgia, Microvascular Decompression Surgery
Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
Essential trigeminal neuralgia is the most common facial pain. In forms resistant to drug and disabling treatments, surgical treatment may be offered to the patient.
- Conditions
- Trigeminal Neuralgia, Microvascular Decompression Surgery, Diffusion Tensor Imaging
- Trial name
- SENSE (NCT05051072)
- Testing
- Assessment of the trigeminal nerve by diffusion tensor MRI and in "resting state" in the context of essential neuralgia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Low Back Pain, Sciatica
Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain
The goal of this quasi-experimental trial was to evaluate the effects of non-surgical spinal decompression on disability and pain in patients with chronic low back pain and sciatica throughout a two-month follow-up, and to…
- Conditions
- Low Back Pain, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06275750
- Testing
- Spinal decompression with BTL-6000 spinal decompression system (BTL Industries Ltd.)
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Hospital Civil de Guadalajara
Adjacent Segment Disease, Cervical Myelopathy
Adjacent Segment Disease After Anterior Cervical Decompression Surgery
Radiculopathy and/or myelopathy due to cervical degenerative disc disease are increasingly common pathologies in our ageing population. Both can be treated non-surgically or surgically.
- Conditions
- Adjacent Segment Disease, Cervical Myelopathy, Cervical Radiculopathy, Degenerative Disc Disease
- Trial name
- ASDafterACDF (NCT04320043)
- Testing
- Anterior cervical decompression
- Where
- Netherlands
- Volunteers
- 673 people
- Sponsor
- Zuyderland Medisch Centrum
Orthopedic Disorder of Spine, Neurologic Disorder
A fMRI Study of Compressive Spinal Cord
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly.
- Trial name
- CSM Plasticity (NCT03504254)
- Testing
- MRI examination
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Lumbar Disc Herniation, Radiculopathy
Application of 3D Printing Guide Plate in Percutaneous Disc Decompression
Application of 3D printing guide plate in percutaneous disc decompression
- Conditions
- Lumbar Disc Herniation, Radiculopathy, Percutaneous Disc Decompression, 3D Printing Guide Plate
- Trial name
- NCT05610553
- Testing
- 3D printing guide plate, Conventional guidance
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University Third Hospital
Degenerative Lumbar Spinal Stenosis
DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion
The purpose of this clinical trial is to evaluate the safety and effectiveness of the DIAM Spinal Stabilization System as a method of treating patients with symptoms of degenerative lumbar spinal stenosis at a single level from…
- Trial name
- NCT00627497
- Testing
- Single-Level Posterior Decompression, DIAM Spinal Stabilization, Fusion
- Where
- 9 sites in United States
- Volunteers
- 32 people
- Sponsor
- Medtronic Spinal and Biologics
Patients With Spinal Stenosis Indicated for LLIF
Indirect vs. Direct Decompression for Treatment of Central Stenosis: RCT
This is a prospective, randomized clinical trial of patients undergoing 1-level lateral lumbar spinal fusion. This study seeks to randomize patients indicated for Lateral Lumbar Interbody Fusion (LLIF) into one of two groups…
- Trial name
- IDVD (NCT04708977)
- Testing
- One-level lateral lumbar interbody fusion with Indirect Decompression, One-level lateral lumbar interbody fusion with Direct Decompression
- Where
- United States
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Degenerative Spondylolisthesis
Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis
This study aims to systematically evaluate the therapeutic efficacy of dual-channel endoscopic spinal decompression versus lumbar decompression with fusion for degenerative lumbar spondylolisthesis.
- Trial name
- NCT07289737
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Degenerative Spondylolisthesis, Spinal Stenosis
Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis
Degenerative spondylolisthesis describes the slip of one spinal segment relative to the adjacent segment. It is usually associated with spinal stenosis (which limits one's ability to walk and stand) and is the most common…
- Trial name
- NCT01921530
- Testing
- Interbody Fusion, Posterolateral Fusion
- Where
- Canada
- Volunteers
- 178 people
- Sponsor
- The London Spine Centre
Lumbar Disc Herniation
Comparison of Ultrasound-Guided Classic And Lateral Approach Thoracolumbar Interfascial Plane Block
US-guided peripheral nerve blocks have been used increasingly due to the advantages of ultrasound in anesthesia practice. TLIP block is one of these nerve blocks performed under US guidance.
- Trial name
- NCT03854240
- Testing
- Classic block (Group C) and modified block (Group M) groups
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University