Clinical trials: Spinal Deformities
Syringomyelia, Arnold Chiari Deformity
A Prospective Natural History Study of Patients With Syringomyelia
Background: Syringomyelia is a disorder in which a cyst (syrinx) forms within the spinal cord and causes spinal cord injury, with symptoms worsening over many years, including paralysis, loss of sensation, and chronic pain.
- Trial name
- NCT01150708
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebellar Ataxia
Effects of Deep Brain Stimulation of the Dentate Nucleus on Cerebellar Ataxia
Cerebellar ataxias are a group of disorders caused by cerebellar affections, for which currently no specific treatment is available.
- Trial name
- NCT03341416
- Testing
- deep brain stimulation on stimulation - active
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Paraplegia, Spinal, Myelomeningocele
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions
The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal…
- Trial name
- NCT01208584
- Testing
- fMRI, DTI
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Motor Disorders
Patients With ALS and Other Motor Disorders Will be Treated With Umbilical or Placental Mesenchymal Cell Exosome Solution
Patients with ALS and other Motor Discorders will be treated with mesenchymal cell exosome solution.
- Trial name
- NCT07105371
- Testing
- Exosome Secretome
- Where
- 2 sites in United States, Greece
- Volunteers
- 70 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Neurogenic Bladder, Myelomeningocele
Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative…
- Trial name
- NCT03550898
- Testing
- Dynamic Ultrasonography
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Spina Bifida
Effects of Progressive Resistance Exercise Training on Endurance and Functional Mobility in Children With Spina Bifida
In this research the effects of progressive resistance exercise training on endurance and functional mobility in children with spina bifida are assessed.
- Trial name
- NCT05719636
- Testing
- Conventional treatment, Progressive resistance exercise
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
SBMA, Spinal and Bulbar Muscular Atrophy (SBMA)
International SBMA Project (KDA)
This project aims at: connecting the existing registries and databases across different countries by comparing the information collected, the administered scales, the biochemical investigations performed; performing a common…
- Trial name
- KDA (NCT07443449)
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Spinocerebellar Ataxia Type 2
Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL)
ATRIL is a multi-centric, double-blind randomized, two-arm controlled study. 42 SpinoCerebellar Ataxia type 2 (SCA2) patients, both gender, at least 18 years of age will be included.
- Trial name
- ATRIL (NCT03347344)
- Testing
- Riluzole
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spina Bifida
Effectiveness of Biofeedback Training in Children with Neurogenic Bladder and Bowel Disorder Wıth Spina Bifida
The aim of this study is to examine and compare the bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life of children diagnosed with spina bifida who did not receive any treatment…
- Trial name
- NCT06618378
- Testing
- Biofeedback exercise combined with breathing exercise, urotherapy educational group
- Volunteers
- 24 people
- Sponsor
- Hasan Kalyoncu University
Spinal Muscular Atrophy 1
Gene Transfer Clinical Trial for Spinal Muscular Atrophy Type 1
The purpose of this trial is to evaluate safety and efficacy of intravenous delivery of AVXS-101 as a treatment of spinal muscular atrophy Type 1 (SMN1).
- Trial name
- NCT02122952
- Testing
- AVXS-101
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Novartis Gene Therapies
Scoliosis, Vitamin D
6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation
The study aimed to: 1. To investigate and compare the changes in bone mineral density (BMD), trabecular bone micro-architecture, bone strength, and curve severity at a mean of 6 years longitudinal follow up in AIS girls with low…
- Conditions
- Scoliosis, Vitamin D, Bone
- Trial name
- NCT02904421
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Adult Spinal Deformity
Neurologic Complications in Spinal Deformity Surgery
240 subjects with "high risk" adult spinal deformity requiring surgical correction will be enrolled in a prospective multi-center international study.
- Trial name
- NCT01305343
- Testing
- Routinely performed surgical correction of spinal deformity
- Where
- 15 sites in United States, Canada and 5 more
- Volunteers
- 273 people
- Sponsor
- AO Foundation, AO Spine
Rett Syndrome
Intensive Anti-Scoliosis Postural Intervention for Individuals With Rett Syndrome Supported by a Smartphone Application
Background: Scoliosis is the most common orthopedic comorbidity in Rett syndrome (RTT), with a prevalence of 94% and a mean curve progression of 14-21° Cobb annually.
- Trial name
- NCT05488938
- Testing
- Rehabilitative Intervention
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ariel University
Ataxia, Spino Cerebellar Degeneration
Ataxia and Exercise Disease Using MRI and Gait Analysis
The first aim is to show balance training improves DCD individual's ability to compensate for their activity limitations, but does not impact disease progression.
- Conditions
- Ataxia, Spino Cerebellar Degeneration, Spinocerebellar Ataxias
- Trial name
- NCT03701776
- Testing
- Aerobic Training, Balance Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Metastatic Castration Resistant Prostate Cancer
A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate Cancer
This clinical trial is evaluating a drug called AC176 in participants with metastatic castration resistant prostate cancer (mCRPC) who have progressed on at least two prior systemic therapies.
- Trial name
- NCT05241613
- Testing
- AC176
- Where
- 5 sites in United States
- Volunteers
- 28 people
- Sponsor
- Accutar Biotechnology Inc
Spinal Muscular Atrophy Type I
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy type I; and to determine if the drug has an effect on SMN mRNA and protein levels.
- Trial name
- NPTUNE 02 (NCT00439218)
- Testing
- sodium phenylbutyrate
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Westat
Neural Tube Defects
Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study
The purpose of the study is to compare the maternal, fetal and neonatal outcomes of a cohort of 60 patients in whom a multilayer closure with a Durepair patch is performed with a prior cohort of patients in whom a standardized…
- Trial name
- NCT03794011
- Testing
- fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine
Spinal Deformity With Sagittal Imbalance
Surgical Treatment of Spinal Deformity With Sagittal Imbalance Using Patient-specific Rods: A Multicenter, Controlled, Double- Blind Randomized Trial: The PROFILE Study
Lumbar degenerative diseases (LDD) are an increasingly common condition affecting millions of patients worldwide. LDD can impact not only function, but can also become markedly disabling and cause severe chronic pain.
- Trial name
- PROFILE (NCT02730507)
- Testing
- Surgery with patient-specific rod, Conventional straight rod
- Volunteers
- 73 people
- Sponsor
- Hospices Civils de Lyon