Clinical trials: Spinal Fractures
Spinal Fusion, Lumbar Fusion
Lumbar Fusion With Porous Versus Non-Porous Cages
The objective of this single site, randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo lumbar interbody fusion procedures (TLIF), supplemented with pedicle screw…
- Conditions
- Spinal Fusion, Lumbar Fusion, Arthrodesis, Spondylolisthesis
- Trial name
- NCT05583864
- Testing
- CONDUIT Porous Titanium Spinal Cage, PROTI 360 Titanium-Coated PEEK Spinal Cage
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Francis Farhadi
Single Level Stable Thoracolumbar Fracture Type AO A3, Multiple Level Stable Thoracolumbar Fracture Type AO A3
Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures
Thoracolumbar fractures are the most common spinal fractures with an average annual incidence between 18 and 30 per 100'000 inhabitants. The majority of these fractures are AO type A3 ("burst fractures").
- Trial name
- FA3 (NCT01751633)
- Testing
- Surgical, Conservative treatment
- Where
- 8 sites in Brazil, Chile and 4 more
- Volunteers
- 38 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Vertebral Fracture
Identification of Microcirculation and Inflammation After Posterior Stabilization of the Spine
In this project, with unstable vertebral fractures, the microcirculation of the skin and muscle (O2C,Laser-Doppler/White-light -Spectroscopy and contrast-enhanced sonography) will be evaluated in both conventional and in…
- Trial name
- MicroSpine (NCT01266200)
- Testing
- Mantis, XIA
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Lumbar Vertebral Fracture
Percutaneous Screw Fixation vs. Open Fixation in the Treatment of Thoracolumbar Fractures
In this single-center retrospective study, the investigators will include all patients admitted to Parkland Hospital who underwent surgical fixation of thoracolumbar fractures between the years 2000 and 2017.
- Trial name
- PrecScrew (NCT04495400)
- Testing
- Thoracolumbar Fracture Fixation
- Where
- United States
- Volunteers
- 485 people
- Sponsor
- University of Texas Southwestern Medical Center
Lumbar Spine Disease
3D Model - Classification of Thoracic and Lumbar Spinal Fractures.
The goal of this clinical trial is to evaluate and compare the effectiveness of a 3D interactive model versus traditional teaching methods in enhancing the teaching of thoracic and lumbar spine fractures classification (AO Spine)…
- Trial name
- NCT06379776
- Testing
- Education through a 3D model, Education through a traditional pedagogical support
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Paris-Sud
Spinal Cord Injuries, Spinal Injuries
DBS of PPN to Improve Walking in Chronic SCI Patients
Spinal cord injury (SCI) is a devastating condition affecting over 1 million individuals in North America. SCI often results in severe motor impairments with few available treatments options.
- Conditions
- Spinal Cord Injuries, Spinal Injuries, Spinal Fractures
- Trial name
- NCT04325165
- Testing
- DBS Implantation
- Sponsor
- University Health Network, Toronto
Femoral Neck Fractures, Regional Anesthesia
Comparison of Regional Anaesthesia Methods for Femoral Neck Fracture Surgery
Femoral fracture surgery is frequently performed especially in geriatric population. Compared to general anaesthesia, regional anaesthesia is preferred to general anaesthesia in the geriatric patient population due to lower…
- Trial name
- NCT06224439
- Testing
- hypobaric spinal anaesthesia, lumbar plexus block, hyperbaric spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Osteoporotic Fracture of Vertebra
Safety and Efficacy of the ISS Sleeve Augmentation Technique in the Treatment of Thoracolumbar Osteopenic Fractures
Implant anchorage is difficult in patient with osteoporotic bone. To improve the implant bone interface, the ISS stabilization system has been developed.
- Trial name
- NCT04495439
- Testing
- Augmentation with the ISS Study System, Augmentation with PMMA
- Where
- Austria
- Volunteers
- 2 people
- Sponsor
- Nexilis AG
Osteoporosis Fracture
Height Loss, Kyphosis Indicators, Bone Mineral Density and Vertebral Fractures in Chinese Postmenopausal Women
This is an observational and cross-sectional study on the height loss, kyphosis indicators, bone mineral density and vertebral fractures in Chinese postmenopausal women
- Trial name
- NCT03798444
- Testing
- dual energy X-ray absorptiometry, lateral spine imaging from T4 to L4 on X-ray
- Where
- China
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Central South University
Hypotension, Pleth Variability Index
Pleth Variability Index and Hypotension
Correct assessment of a patient's volume status is the most important goal for an anesthetist. However, most of the variables used for fluid response evaluation are invasive and technically challenging.Pulse oximeter is a…
- Trial name
- NCT02984956
- Testing
- pleth variability index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzincan University
Vertebral Fracture
Early Percutaneous Vertebroplasty Versus Standard Conservative Treatment in Thoracolumbar Vertebral Fractures
The aim of this study is to evaluate the efficacy of carrying out early vertebroplasty procedure, compared to the standard conservative treatment (corset), in order to prevent residual deformations that could occur in…
- Trial name
- AGIL11 (NCT03617094)
- Testing
- Early percutaneous vertebroplasty (EPV), Standard Conservative treatment (CT)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoporotic Fractures
Optimization of Follow-up of Patients With Symptomatic Recent Osteoporotic Vertebral Fracture
The management of osteoporotic fractures has recently changed with the emergence of new programs dedicated to the diagnosis and treatment of osteoporosis.
- Trial name
- OPTIVERT (NCT03967704)
- Testing
- Life quality evaluation
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoporosis, Rheumatoid Arthritis
Performance of CT Parameters Compared to Bone Mineral Density to Detect Bone Fragility in Rheumatoid Arthritis
Objective: To evaluate the performance of CT parameters (SBAC-L1 and fractal analysis) compared to BMD (gold standard) to detect vertebral fractures in rheumatoid arthritis
- Conditions
- Osteoporosis, Rheumatoid Arthritis, Vertebral Fracture
- Trial name
- NCT04413448
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Central Hospital, Nancy, France
Hip Fractures, COVID-19
Anesthesia Technique in COVID-19 Positive Hip Fracture Patients
Patients with COVID undergoing hip fracture repair have high mortality rates. If spinal anesthesia is associated with decreased rates of mortality, this study could provide hypothesis generating data for prospective studies.
- Conditions
- Hip Fractures, COVID-19, General Anesthesia, Spinal Anesthesia
- Trial name
- NCT05133648
- Testing
- Hip Fracture Surgery, COVID-19 infection
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoporosis Fracture, Spinal Cord Injuries
Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
This is a randomized study to determine the effects of monthly romosozumab for one year or one-time zoledronic acid on bone mineral density (BMD) and biochemical markers of bone formation and resorption, in patients with spinal…
- Trial name
- NCT04597931
- Testing
- Romosozumab, Zoledronic Acid
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Lower Limb Fracture
Comparison of Postoperative Analgesia Between Intravenous Paracetamol and Intranasal Tapentadol
The aim of the study was to compare the analgesic efficacy of intranasal tapentadol nasal spray 44.5mg and intravenous paracetamol 1gm during the postoperative period by Visual analog scale(VAS)in patients undergoing lower…
- Trial name
- NCT05999890
- Testing
- Tapentadol Hydrochloride
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Kempegowda Institute of Medical Sciences, Bangalore
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
SPINAL Fracture
Incidence of Metal Failure During First Year Following Transpedicular Screws Fixation of Dorsolumbar Spine Fracture
Recording incidence of metal failure in transpedicular screws fixation of dorsal umbra spine fracture during first year follow up
- Trial name
- NCT03312998
- Testing
- Xrays
- Volunteers
- 100 people
- Sponsor
- Assiut University
Scoliosis, Scoliosis; Adolescence
Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care
The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question[s]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS)…
- Conditions
- Scoliosis, Scoliosis; Adolescence, Scoliosis Kyphosis, Scoliosis Lumbar Region
- Trial name
- PKSforPSP (NCT06554093)
- Testing
- Medical Device - PKS
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Deep Health Ltd.