Clinical trials: Spinal Hypotension
Orthostatic Hypotension, Spinal Cord Injury
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects…
- Trial name
- NCT00835224
- Testing
- L-NAME, Midodrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Neuromuscular Scoliosis
An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion
The current study would prospectively evaluate the dosing requirements, efficacy and safety of clevidipine for controlled hypotension during spinal surgery in the pediatric population.
- Trial name
- NCT01645111
- Testing
- Clevidipine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nationwide Children's Hospital
Hypotension
Spinal Anesthesia Induced Hypotension During Cesarean Section
The purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during Cesarean sections.
- Trial name
- NCT00846651
- Testing
- Colloid administration, Crystalloid administration, phenylephrine infusion
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Milton S. Hershey Medical Center
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Spinal Induced Hypotension in Cesarean Delivery
Up-Down Determination of the ED90 of Phenylephrine for Hypotension Prophylaxis in Cesarean Delivery
This study is designed to determine the ED90 for an infusion of phenylephrine to prevent spinal induced low blood pressure in parturients presenting for an elective cesarean delivery.
- Trial name
- NCT00796328
- Testing
- Phenylephrine infusion
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Anesthetic Complication Spinal
Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Rapid administration of crystalloid immediately after induction of spinal anesthesia (coload) to be more effective in terms of managing hypotension as compared to administering crystalloid before spinal anesthesia (preload).
- Trial name
- NCT01378325
- Testing
- Phenylephrine, saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Hypotension, Orthostatic, Hypotension
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males…
- Conditions
- Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
- Trial name
- NCT03602014
- Testing
- Northera
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Effects of; Anesthesia, in Labor and Delivery
Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
The purpose of the study is to determine if a medication called phenylephrine, which helps to control blood pressure, is more effective as a continuous intravenous (IV) infusion compared to continuous IV norepinephrine in…
- Trial name
- NCT02354833
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypotension, Postural
Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
Due to de-centralized cardiovascular control, persons with spinal cord injury (SCI) experience blood pressure (BP) dysregulation which manifests in chronic hypotension with exacerbation during orthostatic positioning.
- Trial name
- NCT02307526
- Testing
- Pyridostigmine Bromide, Tilt table test
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury
Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury
Following spinal cord injury autonomic regulation of the cardiovascular system is impaired, which results in a variety of measurable abnormalities in blood pressure.
- Trial name
- NCT02307565
- Testing
- Midodrine
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Obstetric Anesthesia Problems, Bupivacaine Adverse Reaction
Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the…
- Trial name
- bupivacaine (NCT06869434)
- Testing
- Group VBL (Thoracolumbal vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine, Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm, Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight.
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pregnant Women, Pain
Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block.
- Conditions
- Pregnant Women, Pain, Hypotension
- Trial name
- NCT02973048
- Testing
- Hyperbaric bupivacaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Hypotension and Shock, Excessive Amount of Blood / Fluid Infusion
Predict Fluid Responsiveness in Spinal Anesthesia
Spinal anesthesia is still the regional anesthesia technique most widely employed in everyday clinical practice. The most feared and common of its well known side effects consist in an abrupt reduction of systemic vascular…
- Trial name
- CERU-1401 (NCT02070276)
- Testing
- Trans-thoracic echocardiography, Passive Leg Raising Test
- Where
- Switzerland
- Volunteers
- 429 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Hypotension
Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Previous research regarding the use of phenylephrine has excluded obese subjects (BMI >35). This subgroup of patients represents a large portion of the obstetric patient population locally and nationally.
- Trial name
- NCT01481740
- Testing
- Phenylephrine bolus, phenylephrine infusion
- Where
- 2 sites in United States, Canada
- Volunteers
- 178 people
- Sponsor
- IWK Health Centre
Arterial Stiffness, Renin Angiotensin Aldosterone System
RAAS and Arterial Stiffness in SCI
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
- Conditions
- Arterial Stiffness, Renin Angiotensin Aldosterone System, Orthostatic Hypotension, Spinal Cord Injury
- Trial name
- NCT04510974
- Testing
- Spinal Cord Injury
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Hypotension, Spinal Cord Injury
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure.
- Trial name
- NCT00426842
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury
Transcutaneous Stimulation in Spinal Cord Injury
Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving…
- Trial name
- SCI (NCT05180227)
- Testing
- DS8R
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver