Clinical trials: Spinal Paralysis
Spinal Cord Injuries (SCI), Chronic Pain
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
The goal of this clinical trial is to learn whether virtual reality (VR)-based hypnotherapy, added to conventional physiotherapy, improves pain, sleep, mood, and quality of life in adults with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries (SCI), Chronic Pain, Neuropathic Pain, Sleep Disturbance
- Trial name
- HypnoVR-SCI (NCT07846410)
- Testing
- Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Spinal Cord Injuries
Training for Persons With Complete SCI for FES Cycling: a Case Series
The main objective of this study is to validate the effectivity of a simple home-based training for cycling with functional electrical stimulation (FES).
- Trial name
- NCT04412447
- Testing
- Functional Electrical Stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre de Rééducation et Réadaptation Fonctionnelle La Châtaigneraie
Spinal Cord Injury, Paralysis
A Neuroprosthesis for Seated Posture and Balance
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips.
- Conditions
- Spinal Cord Injury, Paralysis, Tetraplegia, Paraplegia
- Trial name
- Trunk Protocol (NCT01474148)
- Testing
- IRS-8 (8-Channel implanted stimulator-telemeter)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Tetraplegia, Spinal Cord Injuries
Virtual Reality Upper Limb Therapy for People With Spinal Cord Injury
This study aims to test if the VR games could be a form of upper limb rehabilitation for people with arm/hand problems due to SCI while they are in hospital.
- Conditions
- Tetraplegia, Spinal Cord Injuries, Upper Extremity Paralysis
- Trial name
- VRULT (NCT06154122)
- Testing
- Virtual Reality Upper Limb Rehabilitation Games, Upper Limb Rehabilitation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Glasgow Caledonian University
Osteopenia, Spinal Muscular Atrophy
Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions
Children with neuromuscular disabilities and limited ambulation are at significant risk for decreased bone mineral density (BMD) and increased incidence of fracture.
- Conditions
- Osteopenia, Spinal Muscular Atrophy, Cerebral Palsy, Muscular Dystrophy
- Trial name
- NCT02428673
- Testing
- Assisted Standing Treatment Program
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Gillette Children's Specialty Healthcare
Neuromuscular Diseases, Congenital Diaphragmatic Hernia
Respiratory Muscles and Work of Breathing in Children
Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology…
- Conditions
- Neuromuscular Diseases, Congenital Diaphragmatic Hernia, Lung Diseases, Cardiac Diseases
- Trial name
- WOB&MR_Ped (NCT05051254)
- Testing
- Esogastric pressure measurement
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy
Short-term Spinal Stimulation Effects in Cerebral Palsy
This research study will examine the acute effects of non-invasive spinal stimulation on spasticity and walking in individuals with cerebral palsy.
- Trial name
- NCT07826494
- Testing
- Spinal Stimulation, Treadmill Walking
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Spinal Tumors, Trauma Patients, Minocycline.
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement
Spinal cord trauma and the consequent paraplegia are possibly among the most devastating injuries in soldiers and during spine surgery, and are significant in the medical, social and financial aspects.
- Trial name
- NCT01813240
- Testing
- Minocycline
- Where
- Israel
- Volunteers
- 444 people
- Sponsor
- Hadassah Medical Organization
Premature Infants, Cerebral Palsy
Interrater Reliability of Infant Motor Profile
The aim of this study is to assess risky infants (or diagnosed infants) with Infant Motor Profile, and analyze interrater and intrarater reliability of this test.
- Conditions
- Premature Infants, Cerebral Palsy, Down Syndrome, Metabolic Disorders
- Trial name
- IMP (NCT03188107)
- Testing
- Video based assessment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Stimulation to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00116337
- Testing
- Spinal Cord Stimulation to restore cough, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MetroHealth Medical Center
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Spinal Cord Injuries, Traumatic Brain Injury
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities.
- Conditions
- Spinal Cord Injuries, Traumatic Brain Injury, Spina Bifida, Cerebral Palsy
- Trial name
- M2M LEADERS (NCT03797378)
- Testing
- eM2M
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Tetraplegia, Spinal Cord Injury
Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
The purpose of this research study is to demonstrate the safety and efficacy of using two NeuroPort Arrays (electrodes) for long-term recording of brain activity.
- Trial name
- NCT01364480
- Testing
- Implantation of NeuroPort Arrays in the motor cortex
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michael Boninger
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Tetraplegia, Functional Tetraplegia
Study of Home Use of the Jaco Robotic Manipulation Device by Individuals With Tetraplegia
For all individuals deprived of active and functional motor control of the upper limbs to perform grasping tasks, the restoration of a grasping function becomes a priority.
- Conditions
- Tetraplegia, Functional Tetraplegia, Spinal Cord Injury, Muscular Dystrophy
- Trial name
- TETRAJACO (NCT07680361)
- Testing
- Use of the JACO robotic arm for a period of 2 months
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Association APPROCHE
Spinal Cord Injuries (SCI)
tESCS for Upper Limb Rehab in Spinal Cord Injury
Regaining hand and arm function is an important step towards regaining independence following high-level spinal cord injury (tetraplegia).
- Trial name
- SCIRUS (NCT07208188)
- Testing
- Transcutaneous spinal cord stimulation (tESCS) active group
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Frontotemporal Dementia, Amyotrophic Lateral Sclerosis
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells.
- Conditions
- Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Progressive Supranuclear Palsy
- Trial name
- NCT03225144
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Paraplegia, Spinal Cord Injuries (SCI)
Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO)
ReWalk suit developed by Argo Medical Technologies is designed to enable people with lower limb disabilities to carry out routine ambulatory functions (stand, walk etc.); it can be used by people with disabilities such as spinal…
- Trial name
- NCT01251549
- Testing
- ReWalk - a motorized exoskeleton suit
- Where
- 2 sites in United States, Italy
- Volunteers
- 32 people
- Sponsor
- ReWalk Robotics, Inc.
Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis)
Biofluid Research on Age-Related or Inherited Neurodegeneration
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with…
- Conditions
- Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial Frontotemporal Lobar Degeneration (fFTLD)
- Trial name
- BRAIN (NCT07798700)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania