Clinical trials: Spinal Reflexes
Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury
Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity
Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain.
- Conditions
- Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT07792616
- Testing
- Transcutaneous spinal stimulation at 30 Hz, Transcutaneous spinal stimulation at 75 Hz, Tizanidine
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
H-reflex, Spinal Reflexes
H-Reflex Suppression by Bone Myoregulation Reflex During Mechanical Loading in Standing Humans
This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing…
- Conditions
- H-reflex, Spinal Reflexes, Posture, Weight-Bearing
- Trial name
- BMR-HREF (NCT07043595)
- Testing
- Whole-Body Vibration (WBV)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Bulbocavernosus Reflex, Spinal Cord Injuries
Evaluation of the Bulbocavernosus Reflex After Acute Spinal Cord Injury
The purpose of this study is to evaluate the possibility to use electromyography in acute phase after a traumatic spinal cord injury to measure quantitatively and objectively the bulbocavernosus reflex.
- Trial name
- NCT04316195
- Testing
- Assessment of the bulbocavernosus reflex
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Andréane Richard-Denis
Hypotension (MeSH: D007022), Bradycardia
Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it is frequently complicated by maternal hypotension and bradycardia.
- Trial name
- NCT07883772
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Aydin Adnan Menderes University
Cerebral Palsy, Spastic Cerebral Palsy
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times/week. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and…
- Trial name
- SRC-CP (NCT05571033)
- Testing
- Spinal reflex conditioning
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute
Healthy Young Adults
Remote Ischemic Conditioning and Spinal Reflex Modulation
Remote ischemic conditioning (RIC) is a clinically feasible method that protects distant organs from severe injury through brief, sub lethal periods of ischemia followed by re-perfusion.
- Trial name
- NCT06860464
- Testing
- Remote Ischemic Condtioning (RIC), Balance training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Healthy
Spinal Cord Plasticity
This study will examine the role of the spinal cord in improving leg movements after physical training in healthy people. The results of this study may be helpful in developing new rehabilitation therapies for people with…
- Trial name
- NCT00073606
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spasticity, Muscle
Assessment of the Excitability of Spinal Motoneurons Using Stimulus-response Curves of the Bulbocavernosus Reflex
Spasticity is commonly observed in neurological conditions such as Multiple Sclerosis and spinal cord injury. "Peripheral" spasticity, concerning in particular the striated muscles of the limbs is nowadays well known and studied…
- Trial name
- NCT04022187
- Testing
- Observational study : no intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Pierre and Marie Curie University
Spinal Cord Injuries
Somato-sensory Reflex Arch in Spinal Cord Injury - Effect on Colorectal Transport
Spinal cord injury (SCI) usually affects young people and causes severe bowel and bladder dysfunction. Recently, the concept of a surgically created somato-sensory reflex arch for bladder dysfunction in SCI has been introduced.
- Trial name
- NCT01274312
- Testing
- Xiao procedure
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Spinal Cord Injury(SCI)
The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations. In parallel with the spinal circuit adaptation, the muscular properties also adapt.
- Trial name
- NCT01968096
- Testing
- home-based ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Subluxation of Joint of Lumbar Spine
The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment
This study investigated the effects of spinal manipulation on central nervous system activity. The presence of postactivation potentiation, an increase in muscular force production following prior muscular contractions, was…
- Trial name
- NCT02848456
- Testing
- Spinal Manipulation, Max Voluntary Isometric Contraction, SM+MVIC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Grant Sanders
Restless Legs Syndrome
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome
This study will examine the effects of the drug Ropinirole on spinal cord reflexes and on symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00051961
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Lumbosacral Radiculopathy
Effects of Multimodal Physical Therapy in Patients With Lumbosacral Radiculopathy
Purposes of the study To investigate the effect of Multimodal Physical Therapy on pain, daiablility H-reflex, and Diffusion Tensor Imaging (DTI) Parameters in Patients With Lumbosacral Radiculopathy.
- Trial name
- NCT06058806
- Testing
- Multimodal Physical Therapy
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Cairo University
Spinal Induced Hypotension
Ephedrine Versus Ondansetron During Cesarean Delivery
More than 30% of the patients receiving spinal anesthesia develop hypotension. Hypotension developed during cesarean section (C/S) under spinal anesthesia may jeopardize uteroplacental circulation leading to fetal compromise and…
- Trial name
- NCT05127876
- Testing
- Ondansetron 4 MG, Ondansetron 8mg, EPHEDrine 10 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ain Shams University
Hypotension, Spinal Anesthesia
Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT07678723
- Testing
- Not applicable- observational study
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing…
- Trial name
- TENS (NCT06541015)
- Testing
- InTENSity 10 TENS Stimulator
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Brain Death
Neurophysiological Examination in Patients With Brain Death
This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers.
- Trial name
- NCT03262896
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Mental Fatigue
Mental Fatigue Effects on Posture and Spinal Reflexes
This randomized crossover study investigates the effects of mental fatigue on postural control and spinal reflex excitability in healthy physically active adults aged 18-35 years.
- Trial name
- NCT07650903
- Testing
- Mental Fatigue Induction, Control Condition
- Where
- Belgium
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina