Clinical trials: Spinal Trauma
Male Osteoporosis
Efficacy in Reducing Fractures and Safety of Zoledronic Acid in Men With Osteoporosis
This study will investigate if the drug zoledronic acid given once yearly is safe and has beneficial effects in treating osteoporosis by reducing bone loss and fractures in men with osteoporosis.
- Trial name
- NCT00439647
- Testing
- Zoledronic acid 5 mg iv
- Where
- 128 sites in Argentina, Australia and 21 more
- Volunteers
- 1,199 people
- Sponsor
- Novartis Pharmaceuticals
Spinal Cord Injuries
Effect of Vibration Exercise on Upper Limb Strength, Function, and Pain
The primary purpose of this study is to explore the benefits of vibration dumbbell resistance training over standard dumbbell resistance training for improving upper limb strength, function and pain among manual wheelchair users…
- Trial name
- NCT02998021
- Testing
- Vibrating Dumbbell, Standard Dumbbell
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alicia Koontz
Spinal Cord Injuries
Coaching for Caregivers of Children With Spinal Cord Injury
This pilot study has two aims. The first aim is to establish the feasibility of coaching for caregivers of youth with spinal cord injury, and the second aim is to establish methodological procedures for a future multi-center…
- Trial name
- NCT03898700
- Testing
- strength based coaching
- Where
- 3 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Metastatic Cancers, Multiple Myeloma
Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer
Vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers.
- Conditions
- Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT02376933
- Testing
- Vertebroplasty, Radiotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Arizona
Surgical Site Infection
Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery
This study will evaluate the safety of povidone-iodine irrigation in pediatric spinal patients by collecting pre- and post-operative safety labwork.
- Trial name
- NCT02527512
- Testing
- Povidone-Iodine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Spinal Cord Injury
Study of an Implantable Functional Neuromuscular Stimulation System for Patients With Spinal Cord Injuries
OBJECTIVES: I. Establish the procedures for implementing and assessing the clinical utility of functional neuromuscular stimulation using an implanted eight-channel standing and transfer system in patients with incomplete…
- Trial name
- NCT00004445
- Testing
- Surgery, IRS-8
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Case Western Reserve University
Spinal Cord Injury, Muscle Spasticity
Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs.
- Trial name
- NCT00041717
- Testing
- Fampridine-SR
- Where
- 45 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Acorda Therapeutics
Spinal Cord Injury, Spinal Cord Injury Cervical
Neuromodulation After Spinal Cord Injury to Improve Limb Function
The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement.
- Trial name
- NCT06815601
- Testing
- rTMS, Motor training
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Acute Spinal Cord Injury
AC105 in Patients With Acute Traumatic Spinal Cord Injury
The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.
- Trial name
- AC105 (NCT01750684)
- Testing
- AC105
- Volunteers
- 15 people
- Sponsor
- Acorda Therapeutics
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Pain
Use of On-Q Pump for Pain Post C-Section
The main purpose of this study is to examine if pain levels treated with intrathecal (IT) preservative-free morphine (PFM) after a cesarean section improve with the additional use of continuous subfascial wound infiltration with…
- Trial name
- NCT02579629
- Testing
- Ropivacaine 0.1%, Ropivacaine 0.2%, Normal saline
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Emory University
Cervical Spinal Cord Injury
Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
The purpose of this study is to determine the efficacy and safety of VX-210 in subjects with Acute Traumatic Cervical Spinal Cord Injury.
- Trial name
- NCT02669849
- Testing
- VX-210
- Where
- 39 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Urinary Incontinence, Overactive Bladder
Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1
The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® (AbobotulinumtoxinA) doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult…
- Trial name
- CONTENT1 (NCT02660138)
- Testing
- Botulinum toxin type A
- Where
- 81 sites in United States, Canada and 8 more
- Volunteers
- 227 people
- Sponsor
- Ipsen
Overactive Bladder
A Long-term Follow-up Study of Botulinum Toxin Type A in Patients With Overactive Bladder as a Result of Spinal Injury or Multiple Sclerosis
The purpose of this study is to assess the long-term safety and effectiveness of botulinum toxin type A on patients with overactive bladder as a result of spinal cord injury or multiple sclerosis.
- Trial name
- NCT00876447
- Testing
- Botulinum Toxin Type A 300U, Botulinum Toxin Type A 200U
- Where
- 22 sites in United States, Australia and 20 more
- Volunteers
- 397 people
- Sponsor
- Allergan
Neuromuscular Scoliosis
Wound Vac Bandage Comparison After Spinal Fusion
The purpose of this study is to evaluate the effectiveness of incisional vacuum-assisted closure (VAC) therapy in the prevention of infection after posterior spinal fusion for pediatric neuromuscular scoliosis, in comparison to a…
- Trial name
- WV (NCT03000010)
- Testing
- Incisional Wound Vac, Standard Bandage
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Spinal Cord Injuries
Benefits of Applying Neuroprosthesis to Improve Grasping and Reaching in Spinal Cord Injury Patients
Functional electrical stimulation is a process that uses low intensity electrical pulses generated by an electric stimulator to create muscle contractions.
- Trial name
- NCT00221117
- Testing
- Neuroprosthesis-FES Therapy, Conventional Ocupational Therapy (COT)
- Volunteers
- 22 people
- Sponsor
- Toronto Rehabilitation Institute