Clinical trials: Spine, Open
Multiple System Atrophy, Parkinson Variant (Disorder)
DBS and SCS Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism
Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder and symptomatic therapeutic strategies are still limited.The parkinsonian type of MSA (MSA-P) has parkinsonian symptoms as its prominent…
- Trial name
- NCT04617873
- Testing
- Bilateral STN-DBS and T10-T12 SCS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- zhangyuqing
Spinal Fusion, Pain Management
PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery
The primary objective of this study is to characterize the pharmacokinetic (PK) profile of EXPAREL when administered via local wound infiltration to subjects undergoing open spinal fusion or reconstructive surgery.
- Trial name
- NCT02985762
- Testing
- EXPAREL
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Lumbar Spinal Stenosis, Spinal Stenosis
Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis
Long-term clinical results of two methods of surgical treatment (spinal decompression with or without fusion) in patients with single-level lumbar stenosis will be compared.
- Conditions
- Lumbar Spinal Stenosis, Spinal Stenosis, Spinal Fusion
- Trial name
- NCT05273879
- Testing
- decompression, fusion
- Where
- 2 sites in Russia
- Volunteers
- 86 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Spina Bifida
QUALAS Validation in Dutch
Rationale Patients with spina bifida often experience a decreased quality of life compared to patients without spina bifida. The Quality of Life Assessment for Spina Bifida (QUALAS) is a validated questionnaire to assess the…
- Trial name
- NCT06723951
- Testing
- QUALAS survey
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Spina Bifida
Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder
The purpose of this research study is to determine the effectiveness of a treatment called "transcutaneous tibial nerve stimulation" or "TTNS" in the treatment of urinary leakage for patients with spina bifida.
- Trial name
- NCT06025734
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS) treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Spina Bifida, Myelomeningocele
Fetoscopic Repair of Isolated Fetal Spina Bifida
The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital.
- Conditions
- Spina Bifida, Myelomeningocele, Chiari Malformation Type 2, Neural Tube Defects
- Trial name
- NCT03090633
- Testing
- Fetoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Spina Bifida
Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial
Spina Bifida is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube, leading to serious malformations of the nervous system.
- Trial name
- IRRICO (NCT02361450)
- Testing
- Retrograde Colonic Irrigation, Usual Care
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Cerebral Palsy, Mobility Limitation
Robotic Walking for Children Who Cannot Walk
A common problem among children with nervous system disorders is difficulty walking on their own. This has impacts beyond mobility including short and long-term health conditions associated with physical inactivity and different…
- Conditions
- Cerebral Palsy, Mobility Limitation, Brain Injuries, Spinal Cord Injuries
- Trial name
- RoWaCaWa (NCT05473676)
- Testing
- Robotic Training Period
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Calgary
Stem Cell Infusion
Outcomes of Autologous Bone Marrow Mononuclear Cell Administration in the Treatment of Neurologic Sequelea in Children With Spina Bifida
The aim of this study was to evaluate the safety and efficacy of autologous bone marrow mononuclear cell infusion in the management of neurological sequelae in children with spina bifida
- Trial name
- NCT05472428
- Testing
- Autologous bone marrow mononuclear cell transplantation
- Where
- Vietnam
- Volunteers
- 11 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Spina Bifida, Myelomeningocele
Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida - A Pilot Study
Researchers are studying a new minimally invasive technique (fetoscopic repair) for repair of spina bifida (MMC) during the second trimester of pregnancy.
- Conditions
- Spina Bifida, Myelomeningocele, Neural Tube Defects
- Trial name
- NCT03936322
- Testing
- Minimally invasive fetoscopic repair of MMC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodrigo Ruano
Children, Mobility Limitation
Parental Perspectives of Using Toy Cars on Social Interactions of Preschool Children With Mobility Impairments
The purpose of this study is to investigate parental attitudes towards their child who has a mobility impairment, to using a modified electric toy car, and to evaluate from their perspective, if it facilitated social interaction…
- Conditions
- Children, Mobility Limitation, Spina Bifida, Attitude to Health
- Trial name
- NCT02682043
- Testing
- Toy car
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Spina Bifida, Neurogenic Bowel
Bowel Continence Across the Lifespan in People With Spina Bifida
The goal of this observational study is to learn how different enema programs affect bowel control in children and adults with spina bifida.
- Conditions
- Spina Bifida, Neurogenic Bowel, Bowel Incontinence
- Trial name
- BCALS (NCT07390318)
- Testing
- Retrograde Enema, Antegrade Enema
- Where
- 24 sites in United States
- Volunteers
- 943 people
- Sponsor
- David Chu
Pregnancy, Fetal and Neonatal Health
Outcome of Fetal Spina Bifida
Neural tube defects are one of the most prevalent congenital abnormalities, surpassed only by cardiac malformations. Spina bifida accounts for the majority of the neural tube defects and is comprised of a wide spectrum of…
- Trial name
- NCT01100697
- Where
- Germany
- Volunteers
- 103 people
- Sponsor
- University of Luebeck
Degenerative Disc Disease
Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating
The purpose of this combined retrospective and prospective clinical study is to examine the clinical outcomes of the ROI-C® anterior cervical interbody fusion device with VerteBRIDGE® plating to treat single level degenerative…
- Trial name
- NCT02104167
- Testing
- ROIC interbody cage with VerteBRIDGE plating
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- LDR Spine USA
Executive Dysfunction, Cognitive Deficits
Cognitive Rehabilitation in Patients With Spina Bifida
This study will examine the effects of a theoretically grounded and manualized cognitive rehabilitation program on patients with Spina Bifida (SB).
- Conditions
- Executive Dysfunction, Cognitive Deficits, Spina Bifida
- Trial name
- NCT01302314
- Testing
- Goal management training (GMT)
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Jan Stubberud
Spina Bifida, Myelomeningocele
Prospective Cohort of Transitional Urology Patients
A transitional Urology database was created in parallel with National Spina Bifida registry to follow patients with complex congenital urogenital anomalies and be able to prospectively evaluate them.
- Conditions
- Spina Bifida, Myelomeningocele, Meningocele, Bladder Exstrophy
- Trial name
- NCT03061084
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Methodist Hospital Research Institute
Urinary Incontinence, Spinal Cord Injury
Lumbar to Sacral Ventral Nerve Re-Routing
To assess the level of improvement in voiding function after lumbar to sacral ventral nerve re-routing procedure in Spinal Cord Injury and spina bifida patients
- Conditions
- Urinary Incontinence, Spinal Cord Injury, Spina Bifida
- Trial name
- NCT00378664
- Testing
- lumbar to sacral ventral nerve re-routing procedure
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kenneth Peters, MD
Lumbar Foraminal Stenosis
Comparative Study Between Lumbar Foraminal Stenosis Treatment Modalities
The goal of this clinical trial is to compare the clinical and radiological outcome of two different interventional techniques in lumbar foraminal stenosis decompression.
- Trial name
- NCT06686407
- Testing
- Open lumbar decompression ± fusion, Minimally invasive lumbar foraminal decompression using unilateral biportal endoscopy "device"
- Volunteers
- 32 people
- Sponsor
- Assiut University
Spina Bifida
Physical Capacity of Spina Bifida and Factors Affecting
Objective: It was aimed to evaluate the physical characteristics of the cases with spina bifida and to review the factors that may affect the etiology of the disease.
- Trial name
- NCT06541366
- Testing
- case-control study
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Sacral Myelomeningocele, Neural Tube Defects
In Utero Fetoscopic Repair Program for Sacral Myelomeningoceles and Mye-LDM
The purpose of the study is to evaluate the feasibility and the maternal, fetal and postnatal outcomes of sacral myelomeningocele (MMC) and Myelic Limited Dorsal Myeloschisis (MyeLDM) fetoscopic repair at Trousseau Hospital…
- Conditions
- Sacral Myelomeningocele, Neural Tube Defects, Spina Bifida
- Trial name
- PRIUM2 (NCT04770805)
- Testing
- Fetoscopy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris