Clinical trials: Spine Cancer
Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System
Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases
The goal of this clinical research study is to learn whether delivering spine radiosurgery in a single large dose is better than delivering spine radiosurgery over 3 smaller doses.
- Trial name
- NCT03028337
- Testing
- Spine Radiosurgery, Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Breast and Other Cancer Incidence and Mortality, All Cause Mortality
Follow-Up Study of People Treated for Scoliosis
Background: Scoliosis is a curving of the spine. It usually happens in girls when they are children and teens. Doctors often use x-rays to diagnose it. The x-rays give low radiation.
- Conditions
- Breast and Other Cancer Incidence and Mortality, All Cause Mortality, Circulatory Disease Mortality, Respiratory Disease Mortality
- Trial name
- NCT02546479
- Where
- United States
- Volunteers
- 5,573 people
- Sponsor
- National Cancer Institute (NCI)
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Degenerative Disc Disease, Herniated Disc
Bone Graft Materials Observational Registry
A multi-center, prospective, observational patient registry to collect information on the clinical outcomes and "real world" use of approved and commercially available bone graft substitutes, autograft and allograft.
- Conditions
- Degenerative Disc Disease, Herniated Disc, Spinal Stenosis, Spondylolithesis
- Trial name
- APPROACH-001 (NCT00974623)
- Testing
- Bone graft substitute, autograft or allograft
- Where
- 14 sites in United States, Hungary and 1 more
- Volunteers
- 329 people
- Sponsor
- Baxter Healthcare Corporation
Hepatocellular Carcinoma, Spine Metastasis
Diffusion-Weighted Magnetic Resonance Imaging
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment…
- Trial name
- NCT02242786
- Testing
- External beam radiation therapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Samsung Medical Center
Adult Spinal Cord Neoplasm, Spinal Bone Metastases
Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
This pilot clinical trial studies beta-tricalcium phosphate bone graft in treating patients undergoing surgery for metastatic spine cancer.
- Conditions
- Adult Spinal Cord Neoplasm, Spinal Bone Metastases, Spinal Cord Compression
- Trial name
- NCT01407341
- Testing
- musculoskeletal complications management/prevention, bone graft, quality-of-life assessment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Breast Cancer Surgery, Postoperative Pain, Acute
Chronic Pain in Post-Mastectomy Patients; The Difference Between Pectoral Nerve (PECS I-II) and Erector Spinal Plane (ESP) Blocks
This study looks at two types of injections (called PECS and ESP blocks) to see which one works better for reducing pain after breast cancer surgery (mastectomy).
- Conditions
- Breast Cancer Surgery, Postoperative Pain, Acute, Postoperative Pain, Chronic, Post-mastectomy Pain Syndrome
- Trial name
- NCT06900842
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hacettepe University
Motor Evoked Potential Monitoring, General Anesthesia
Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is…
- Conditions
- Motor Evoked Potential Monitoring, General Anesthesia, Neurosurgery, Brain Tumor
- Trial name
- NCT01690364
- Testing
- MEP monitoring with continuous infusion of vecuronium during general anesthesia, MEP monitoring with continuous infusion of cisatracurium during general anesthesia
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Samsung Medical Center
Chordoma, Chondrosarcoma
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose.
- Trial name
- NCT00592748
- Testing
- Charged Particle Radiation Therapy
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- Massachusetts General Hospital
Spinal Cord Tumor of Cervical Spine
3T MRI of Intramedullary Spinal Cord Tumours
Intramedullary spinal cord tumours (IMSCTs) are a type of tumour that arises from cells within the spinal cord. They are rare, accounting for around 4-10% of central nervous system tumours.
- Trial name
- NCT05664438
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Spinal Metastases
Preoperative Embolization in Surgical Treatment of Spinal Metastases.
The main purpose of this study is to assess the efficacy of preoperative embolization in decreasing operative blood loss, decreasing the need for intraoperative transfusion and facilitate surgical resection in metastatic spine…
- Trial name
- NCT01365715
- Testing
- Arteriography and preoperative embolization, Arteriography
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intraspinal Tumor
Finite Element Study of Biomechanical Changes After Unilateral Hemilamina and Facet Joint Resection of Cervical Spine
Finite element method was used to simulate unilateral hemilaminectomy of cervical spine and facet joint resection of different degrees, and the range of motion and the stress changes of ligament, intervertebral disc and endplate…
- Trial name
- NCT04957056
- Testing
- Hospitalization
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Peking University Third Hospital
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Prostate Cancer, Spine, Open
Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for…
- Conditions
- Prostate Cancer, Spine, Open, Hip Osteoarthritis, Knee Disease
- Trial name
- NCT06144099
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Glioma, Medulloblastoma
PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications
Background: About 90,000 new cases of brain and spinal cord tumors are diagnosed annually in the United States. Most of these tumors are benign; however, about 30% are malignant, and 35% of people with malignant tumors in the…
- Conditions
- Glioma, Medulloblastoma, Ependymoma, Glioblastoma
- Trial name
- NCT06161519
- Testing
- PLX038
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- National Cancer Institute (NCI)
Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis
Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries
This randomized phase II trial is studying zoledronate to see how well it works compared to observation in maintaining bone mineral density in patients who are undergoing surgery to remove both ovaries.
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis, Ovarian Carcinoma
- Trial name
- NCT00305695
- Testing
- Laboratory Biomarker Analysis, Zoledronic Acid
- Where
- 95 sites in United States
- Volunteers
- 160 people
- Sponsor
- Gynecologic Oncology Group
Degenerative Disc Disease, Spondylolisthesis
PMCF Neo Pedicle Screw and Cage Systems
The objectives of this clinical observational study is to evaluate the safety and efficacy (performance) of the Neo Pedicle Screw System™ and the Neo Cage System™ interbody fusion device.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Spinal Tumor
- Trial name
- NCT03956537
- Testing
- NEO Pedicle Screw System™, Neo Cage System™
- Where
- 2 sites in Germany, Spain
- Volunteers
- 150 people
- Sponsor
- Neo Medical SA
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley
Spinal Tumor, Spinal Disorder
Duke Spine Outcome Study (DSOS)
The primary goal of this registry is to increase the knowledge about spine tumors and other spine disorders to guide appropriate management strategies for the future.
- Trial name
- DSOS (NCT04217525)
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Duke University
Cancer, Spinal Fractures
CAFE Study - Cancer Patient Fracture Evaluation
The primary objective of this study is to evaluate the safety and effectiveness of balloon kyphoplasty treatment for painful, acute, vertebral compression fractures (VCFs) as compared to standard non-surgical therapy in patients…
- Trial name
- CAFE (NCT00211237)
- Testing
- Balloon Kyphoplasty, Non Surgical Management
- Where
- 20 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Medtronic Spine LLC