Clinical trials: Spine Disease
Degenerative Disc Disease, Spondylolisthesis, Grade 1
AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY
This is a post-market clinical study of the AccuLIF expandable transforaminal lumbar interbody fusion (TLIF) cage in patients requiring surgery for degenerative disc disease (DDD) with up to Grade I spondylolisthesis or…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Grade 1, Retrolisthesis
- Trial name
- APROPOS (NCT02704689)
- Testing
- AccuLIF expandable TLIF cage
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VB Spine, LLC
Lumbar Intervertebral Disc Herniation
Lumbar Disc Herniation Outcome Measures
This study is being conducted to examine outcome measurements on patients who undergo surgery to removed a damage lumbar spine disc versus those that chose not to have surgery.
- Trial name
- NCT01041391
- Testing
- Discectomy-lumbar spine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- State University of New York - Upstate Medical University
Lumbar Spinal Stenosis
Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial
The goal of this clinical trial is to prospectively evaluate the effects of essential amino acid (EAA) supplementation on the volume and structure of the muscles surrounding the spine (paraspinal musculature).
- Trial name
- NCT06579391
- Testing
- Essential amino acids, Alanine
- Where
- United States
- Sponsor
- University of California, Irvine
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Lumbar Spine Disease
Effectiveness of Home Programs After Lumbar Spinal Decompression Surgery
The study will be conducted with volunteer patients who are followed up by Bursa Çekirge State Hospital Cekirge State Hospital Neurosurgery outpatient clinic and who have undergone lumbar decompression surgery and who meet the…
- Trial name
- NCT06014645
- Testing
- Rehabilitation, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Muğla Sıtkı Koçman University
Spondylitis, Ankylosing, Axial Spondyloarthritis
Analysis of DNA Methylation in Spondyloarthritis
The aim of this project is to quantify global DNA methylation in patients with Ankylosing Spondylitis or Axial Spondyloarthritis as compared with control subjects.
- Conditions
- Spondylitis, Ankylosing, Axial Spondyloarthritis, DNA Methylation
- Trial name
- METYLAS (NCT03092583)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Scoliosis, Restrictive Pulmonary Disease
Cardiorespiratory Assessment Prior to Scoliosis Surgery: a 10-year Experience at a Specialized Scoliosis Center
this study involves adult patients who underwent scoliosis surgery within the last 10 years. The aim of this study is to assess the frequency of scoliosis-related respiratory complications in patients requiring orthopedic…
- Conditions
- Scoliosis, Restrictive Pulmonary Disease, Pulmonary Hypertension, Restrictive Breathing Pattern
- Trial name
- RespiSco (NCT07760441)
- Testing
- respiratory function test
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Poitiers University Hospital
Axial Spondyloarthritis
Ultrasonographic Evaluation of the Shoulder Joint in Patients With Axial Spondyloarthritis
The aim of this observational study is to assess shoulder joint involvement in patients with axial spondyloarthritis using ultrasound and to compare the findings with those of healthy controls.
- Trial name
- NCT06727266
- Testing
- Shoulder ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Disk, Herniated
A Pilot Study of the InterCushion Disc Nucleus Prosthesis (DNP) in Patients Receiving Discectomy
The primary endpoints of the investigation will include assessment of the maintenance of disc height demonstrated by radiographic evidence based on plain radiographs and MRI and relief of pain as measured by Visual Analog Scale…
- Trial name
- NCT01652053
- Testing
- Disc Nucleus Replacement (InterCushion DNP)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Vertebral Technologies, Inc.
Infections Nervous System, Nosocomial Infection
Infections Following NeuroSurgery (INS)
Neurosurgery (NS) is essential for the treatment of various diseases such as malignant tumors, vascular conditions, spinal stenosis or trauma.
- Conditions
- Infections Nervous System, Nosocomial Infection, Bacterial Infections, Antibiotic Resistant Infection
- Trial name
- INS (NCT03857295)
- Testing
- No interventions
- Volunteers
- 150 people
- Sponsor
- Neuromed IRCCS
Psoriasis, Pregnancy
Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Psoriasis, Pregnancy, Psoriatic Arthritis, Crohn Disease
- Trial name
- NCT02103361
- Testing
- Ustekinumab, Guselkumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Spinal Stenosis
MIS-D Versus MIS-TLIF for the Treatment of Lumbar Spinal Stenosis
The purpose of this study is to evaluate the effectiveness of two minimal invasive spine surgery, minimally invasive spinal decompression (MIS-D) and minimally invasive spinal decompression and fusion (MIS-TLIF), for patients…
- Trial name
- NCT04318795
- Testing
- minimally invasive spinal decompression (MIS-D), minimally invasive spinal decompression and fusion (MIS-TLIF)
- Volunteers
- 80 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Juvenile; Scoliosis, Scoliosis Idiopathic
Studying Melatonin and Recovery in Teens
The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgerySMART (NCT06093477)
- Testing
- Fast-Dissolve Melatonin Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Psoriasis, Psoriatic-arthritis
PsoBest - The German Psoriasis Registry
Treatment of moderate to severe Psoriasis (Pso) and Psoriasis-Arthritis (PsA) is largely confined to systemic therapy in Germany. Systemic therapy includes conventional systemic therapy (e.g.
- Trial name
- NCT01848028
- Where
- Germany
- Volunteers
- 3,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Lumbar Disc Herniation, Radiculopathy Lumbar
Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy
Lumbar disc herniation with radiculopathy (LDHR) is the local displacement of the intervertebral disc and its contents beyond the edge of the normal intervertebral disc space, resulting in pain, weakness or numbness in the muscle…
- Trial name
- NCT06611332
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Ankylosing Spondylitis
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs
The goal of this research is to assess the percentage of non-responders to ≥ 2 NSAIDs candidates a biological therapy that could adequately respond to treatment with etoricoxib This study confirm the result of a previous study in…
- Trial name
- NCT01091675
- Testing
- Etoricoxib
- Where
- 14 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Spanish Foundation of Rheumatology
Psoriatic Arthritis (PsA)
Phase 2 Trial of FT2109 for the Treatment of Psoriatic Arthritis
This study will investigate if the study medicine FT2109 can treat symptoms of active Psoriatic Arthritis (PsA). This study assesses the safety and efficacy of FT2109 in adult participants with active PsA who may or may not have…
- Trial name
- NCT07869134
- Testing
- FT2109 Dosing Regimen 1, FT2109 Dosing Regimen 2
- Volunteers
- 210 people
- Sponsor
- Forward Therapeutics
Lumbar Disc Herniation
A Trial of Percutaneous Lumbar Discectomy Combined With Ozone for Treatment of LDH
Lumbar disc herniation (LDH) is a common pathological process leading to spinal surgery. Open discectomy used to be a widespread procedure for surgical treatment for symptomatic LDH.
- Trial name
- NCT02372032
- Testing
- percutaneous lumbar discectomy, ozone therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongda Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Assessment of Pain Management in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Patients Who Are About to be Treated With Adalimumab
The purpose of this study is to assess whether or not adalimumab (Humira®) can influence pain medication in participants with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) with or without…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01273519
- Where
- 15 sites in Austria
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)
Neck Pain, Spondylosis
CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study
The study is a prospective, first-in-human, multi-center, non-randomized, single-arm study to assess the safety and efficacy of the CEM-Cage used with the CEM-Plate in patients who are appropriate candidates for a 2-level…
- Conditions
- Neck Pain, Spondylosis, Spondylosis With Myelopathy, Spondylosis With Radiculopathy
- Trial name
- NCT04883411
- Testing
- CEM-Plate Anterior Cervical Plating System and CEM-Cage Cervical Interbody System
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- ReVivo Medical, Corp.