Clinical trials: Spine Metastases
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Spine Metastasis
A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases
Spine SBRT is considered a standard of care for the treatment of spinal metastases. Compared to conventional radiation therapy, spine SBRT delivers high doses of radiation to the affected areas to the spinal metastases.
- Trial name
- OPTIMAL (NCT07478289)
- Testing
- Radiation Boost
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Bone Lesion, Bone Metastases
Ablation and Cementoplasty for Painful Bone Lesions
The aim of this research study is to assess the effectiveness of combined ablation and cementoplasty in the treatment of spinal, pelvic, and extraspinal lesions causing pain resistant to conventional treatment at our centre.
- Conditions
- Bone Lesion, Bone Metastases, Spine Metastases
- Trial name
- NCT04635137
- Testing
- Ablation and Cementoplasty
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Vertebral Metastasis
Prospective Observational Study on Vertebral Metastasis
Perspective observational cohort study in which the data relating to patients affected by one or more vertebral metastases or by vertebral localization of hemolifoproliferative malact and surgical treatment candidates will be…
- Trial name
- CVODMetsVert (NCT05985434)
- Testing
- Surgical treatment
- Where
- Italy
- Volunteers
- 191 people
- Sponsor
- Istituto Ortopedico Rizzoli
Bone Metastases in Subjects With Advanced Cancer
Research on the Optimization of Treatment for Spinal Metastases With Radioactive Particle Implantation Using TPS and Mechanical Dual Simulation
This prospective, open-label randomized trial evaluates a dual-simulation planning strategy that combines standard brachytherapy TPS with patient-specific biomechanical modeling for radioactive seed implantation in bone…
- Trial name
- NCT07171996
- Testing
- Dual-Simulation TPS + Biomechanical Planning, Conventional TPS Planning
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Headache Disorders, Primary, Headache, Cervicogenic
Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches
Headaches such as tension-type, migraine, and cervicogenic (neck-related) headaches are among the most common and disabling conditions worldwide.
- Trial name
- NCT07309874
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas Tech University Health Sciences Center
Spine Metastasis, Early Goal Directed Therapy
Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.
Although angiographic embolization has been introduced for preoperative management of spine metastases in 1975 and is suggested today by many authors in the management of such pathologies, it needs to be confirmed by RCT.
- Conditions
- Spine Metastasis, Early Goal Directed Therapy, Embolization, Therapeutic, Blood Loss
- Trial name
- Embart (NCT03853434)
- Testing
- Embolization
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cervical Spine Instability
SOS Versus Awake Fiberoptic Intubation
Background: Conventional intubation of the trachea and consequent prone positioning of anaesthetized patients with cervical spine instability may result in secondary neurological injury.
- Trial name
- NCT03075033
- Testing
- Shikani optical stylet, Flexible fiberoptic bronchoscope for
- Volunteers
- 60 people
- Sponsor
- University of Alexandria
Cervicogenic Headache
Effects of Sustained Natural Appophyseal Glide Versus Rocababo 6x6 Program in Subjects With Cervicogenic Headache.
The purpose of this study is to investigate the effects of TMJ directed treatment approach using the Rocabado 6x6 program in patients with cervicogenic headache on the intensity of headache, function of the neck, and quality of…
- Trial name
- NCT05865808
- Testing
- cervical spine mobilization, Rocabado 6x6
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Thoracic Cancer, Spine Cancer
Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine
Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than…
- Conditions
- Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease
- Trial name
- NCT04227717
- Testing
- MRI with custom MRI spine coil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intervertebral Disc Displacement, Intervertebral Disc Degeneration
Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
NOVOCART® Disc plus is being investigated to explore its clinical applicability, safety and efficacy in the repair of a herniated disc with an indication for an elective sequestrectomy, and of the adjacent degenerated disc, if…
- Trial name
- NDisc (NCT01640457)
- Testing
- NOVOCART® Disc plus, NOVOCART® Disc basic
- Where
- 10 sites in Austria, Germany
- Volunteers
- 120 people
- Sponsor
- Tetec AG
Hepatocellular Carcinoma, Spine Metastasis
Diffusion-Weighted Magnetic Resonance Imaging
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment…
- Trial name
- NCT02242786
- Testing
- External beam radiation therapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Samsung Medical Center
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Spinal Metastasis
RELIEVE: Research on Effectiveness of Surgery and Radiotherapy on Relieving Spine Tumor Pain in Patients with Vertebral Metastases
This is a prospective, multicenter, observational study focusing on assessing and managing pain in patients with metastatic spinal tumors.
- Trial name
- RELIEVE (NCT06746103)
- Testing
- Surgery
- Volunteers
- 250 people
- Sponsor
- AO Foundation, AO Spine
Spine Disease, Characteristics Disease
Baseline-characteristics of Patients Referred to a Secondary Spine Centre
A retrospective cohort study will be conducted in Zuyderland Medical Centre Heerlen, the Netherlands. All patients that were referred to the spine-centre between 01.01.2019 and 31.12.2019 will be included for analysis.
- Conditions
- Spine Disease, Characteristics Disease, Spinal Disease, Demography
- Trial name
- CHAPARS (NCT04877470)
- Testing
- Consultation at spine-centre
- Where
- Netherlands
- Volunteers
- 4,855 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Newly Diagnosed Melanoma Metastases in the Brain and Spine
SRS (Stereotactic Radiosurgery) Plus Ipilimumab
This research is being done to look at the safety of using stereotactic radiosurgery (SRS) and Ipilimumab together to treat melanoma that has spread to the brain or spine.
- Trial name
- NCT01950195
- Testing
- Stereotactic Radiosurgery (SRS), Ipilimumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Spinal Metastases
Outcomes of Surgical Treatment of Patients With Spinal Metastasis in AUH
To analyze the outcomes of surgical treatment of patients with spinal metastases in spine unit in AUH regarding the pain control, neurological status and ambulatory status as well as survival rate .
- Trial name
- NCT04110457
- Testing
- spinal decompression
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Metastatic Malignant Neoplasm in the Spine
Medical Data Collection for the Evaluation of Radiofrequency Ablation and Cement Augmentation for the Treatment of Secondary Metastases to the Spine
This study collects data on the use of radiofrequency ablation and cement augmentation for the treatment of cancer that has spread to the spine (metastases to the spine).
- Trial name
- NCT04751422
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- M.D. Anderson Cancer Center
Spinal Metastases, Surgery
CT-DSA Evaluation of Embolization in Debulking Spinal Surgery
Vertebra is one of the most common site of metastatic disease, which may cause severe pain or neurological deficit. Decompressive surgery or radiation therapy are of limited efficacy and recurrence is very likely.
- Trial name
- NCT04497051
- Testing
- CT-DSA
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital