Clinical trials: Spine Osteoarthritis
Spondylarthritis, Axial Spondyloarthritis
Clinical Trial of Electroacupuncture in Axial Spondyloarthritis (E-AcuSpA)
Axial spondyloarthritis (AxSpA) is a chronic disease that causes severe disability and poor quality of life. Current treatment options are limited and there are still significant non-responders to current western medications.
- Trial name
- E-AcuSpA (NCT04519866)
- Testing
- Electroacupuncture, Manual acupuncture
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore General Hospital
Back Pain, Spondylitis, Ankylosing
Biopsychosocial Exploration of Pain Profiles in Inflammatory and Chronic Non-specific Axial Low Back Pain
The biopsychosocial model is well established in chronic low back pain (CLBP) research. Nevertheless, researchers to date have overlooked the biopsychosocial aspects of Inflammatory Low Back pain (ILBP).
- Conditions
- Back Pain, Spondylitis, Ankylosing, Low Back Pain
- Trial name
- NCT02704845
- Where
- 3 sites in Ireland
- Volunteers
- 58 people
- Sponsor
- University of Dublin, Trinity College
Psoriatic Arthritis, Spondylitis
Tofacitinib for Reduction of Spinal Inflammation in Patients With Psoriatic ArthritiS PresenTing With Axial InvOlvement
To evaluate the efficacy of Tofacitinib in reducing inflammation in the sacroiliac joints and spine on magnetic resonance imaging (MRI) in patients with active Psoriatic Arthritis (PsA) with axial Involvement (BASDAI [Bath…
- Conditions
- Psoriatic Arthritis, Spondylitis, Sacroilitis
- Trial name
- PASTOR (NCT04062695)
- Testing
- Tofacitinib 5 MG Oral Tablet [Xeljanz]
- Where
- 19 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Arthritis, Psoriatic
A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice
The purpose of this study is to evaluate treatment persistence with guselkumab and interleukin-17 inhibitor (IL-17i) initiated at enrollment into this study (PsABIOnd).
- Trial name
- PsABIOnd (NCT05049798)
- Testing
- Guselkumab, IL-17i
- Where
- 155 sites in Argentina, Australia and 18 more
- Volunteers
- 1,314 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
PsA (Psoriatic Arthritis)
Effect of Metformin on Carotid Atherosclerosis for Non-diabetic Patients With PsA (CAMPA Study)
Background: Psoriatic arthritis (PsA) is a common chronic inflammatory disease with a prevalence up to 670 every 100,000 subjects.
- Trial name
- NCT05988684
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- Chinese University of Hong Kong
Axial Spondyloarthritis
Reliability of BASDAI and BASFI Applied by Tele-Assessment Method in Axial SpA Spondyloarthritis
The goal of this observational study is to investigate the reliability of BASDAI and BASFI questionnaires applied via tele-assessment in axial spondyloarthritis patients.
- Trial name
- NCT06230952
- Testing
- BASDAI and BASFI reliability
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Siirt University
Rheumatoid Arthritis, Ankylosing Spondylitis
Artificial Intelligence Literacy and E-Health Literacy in Rheumatic Diseases
This study aims to evaluate digital health competencies in individuals with rheumatic and degenerative joint diseases. Specifically, it assesses e-health literacy and artificial intelligence literacy, which refer to individuals'…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Knee Osteoarthritis
- Trial name
- NCT07054749
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Inflammatory Rheumatic Diseases
A Study on Changes in IFN-gamma Levels Following Anti-TNF Treatment in Patients Undergoing Serial QuantiFERON-TB Gold In-Tube
The screening for latent tuberculosis infection (LTBI) prior to the onset of anti-tumor necrosis factor therapy, as well as a watchful monitoring during the treatment, is strongly recommended.
- Trial name
- NCT01475409
- Testing
- QuantiFERON-TB Gold In-Tube (QFT-GIT)
- Volunteers
- 119 people
- Sponsor
- University of Roma La Sapienza
Autoimmune Diseases, Rheumatoid Arthritis (RA)
Study of S-4321 in Participants With an Autoimmune or Immune-mediated Disease
This is a multi-center, open-label Ph 1b basket study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, biomarker response, and preliminary efficacy of multiple doses of S-4321 in…
- Conditions
- Autoimmune Diseases, Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Psoriasis (PsO)
- Trial name
- NCT07455578
- Testing
- S-4321
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Seismic Therapeutic AU Pty Ltd
Arthritis, Psoriatic, Arthritis, Rheumatoid
Effectiveness of Digital Rehabilitation (SIMPLI.REHAB) in Hand Arthritis
This study investigates the effectiveness of SIMPLI.REHAB, a digital tool employed as an interface for administering occupational rehabilitation programs to patients diagnosed with Rheumatoid and Psoriatic Arthritis.
- Conditions
- Arthritis, Psoriatic, Arthritis, Rheumatoid, Deformity, Hand, Limitation, Mobility
- Trial name
- NCT06077890
- Testing
- Digital Rehabilitation, Conventional Rehabilitation
- Where
- Portugal
- Volunteers
- 35 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Psoriatic Arthritis
TNF and IL23 Blocking Agents Gene Expression Ratios in the Psoriatic Arthritis Synovium_(TIGERS) Study
This study compare the genomics profiles in synovial biopsies obtained prior to, and 24 weeks after a biologic disease modifying anti-rheumatic drugs (DMARDs)(Adalimumab, Ustekinumab, Guselkumab) in patients with active psoriatic…
- Trial name
- TIGERS (NCT04261010)
- Testing
- Global/single cell gene expression profiles obtained from Synovial biopsies
- Where
- 2 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Spondylodiscitis
Follow up Patients With Thoracolumbar Spondylodiscitis Surgically Treated by Posterior Approach
To evaluate the long term outcomes of patients with thoracolumbar spondylodiscitis treated surgically by posterior approach. Outcomes include bony fusion, neurological improvement, pain improvement, implant related complication…
- Trial name
- NCT04749082
- Volunteers
- 40 people
- Sponsor
- Assiut University
Spondyloarthropathies, Ankylosing Spondylitis
Faecal Analyses in Spondyloarthritis Therapy
This study evaluates the intestinal microbiome and disease activity in patients with spondyloarthropathies receiving immunosuppressive therapy.
- Trial name
- FAST (NCT03839862)
- Testing
- TNF-inhibition
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Arthritis, Psoriatic
Investigation of 9 Consecutive Infusions of Remicade for Psoriatic Arthritis in Austria (Study P04264)
This is a prospective, open-label, 1-arm, multicenter observational study to determine the dose and time interval of Remicade (Infliximab) infusions in psoriatic arthritis (PsA).
- Trial name
- NCT00725296
- Testing
- Remicade (Infliximab)
- Volunteers
- 178 people
- Sponsor
- Merck Sharp & Dohme LLC
Spinal Tuberculosis, Mesenchymal Stem Cell
Effectivity of Mesenchymal Stem Cell on Vertebral Bone Defect Due to Mycobaterium Tuberculosis Infection
This study evaluates the effectiveness of locally implantation of mesenchymal stem cell on vertebral bone defects due to infection of mycobacterium tuberculosis.
- Trial name
- NCT04493918
- Testing
- Mesenchymal Stem cell + Nacl 0.9%, NaCl 0.9%
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Ahmad Jabir Rahyussalim
Spondyloarthritis (SpA), Psoriatic Arthritis (PsA)
Assessment of Nutritional Status in Rheumatic Diseases and Association to Disease Activity
The aim of the present work is to assess the nutritional status among different rheumatic diseases patients and to study its association with the corresponding diseases activity.
- Conditions
- Spondyloarthritis (SpA), Psoriatic Arthritis (PsA), Systemic Lupus Erythematous (SLE), Systemic Sclerosis (SSc)
- Trial name
- NCT07277491
- Where
- Egypt
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spondyloarthritis, Axial, Arthritis, Psoriatic
Influence of Sodium Intake in spondyLoarthriTes
The aim of the SALT study is to analyze the relationship between dietary sodium intake and disease activity in patients with axial spondyloarthritis (radiographic or non-radiographic) or psoriatic arthritis.
- Trial name
- SALT (NCT06259890)
- Testing
- measurement of salt intake
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rheumatoid Arthritis, Osteoarthritis
Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy
The purpose of this study is to evaluate the efficacy of eupatilin on the prevention of gastroenteropathy in patients with NSAIDs and low dose steroid by comparing with rebamipide.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Other Musculoskeletal Disorder
- Trial name
- CEERS (NCT04885751)
- Testing
- Eupatilin, Rebamipide
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul National University Boramae Hospital
Psoriatic Arthritis
to Translate and Validate the TOPAS TORONTO PSORIATIC SCREENING QUESTIONNAIRE)Into Spanish
TO TRANSALETE AND VALIDATE DE TORONTO PSORIATIC ARTHRITIS SECREENING QUESTIONAIRE INTO SPANISH
- Trial name
- spanishTopas (NCT01891903)
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Reumatologia Integral LTDA
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