Clinical trials: Spine Osteoarthritis
Psoriatic Arthritis
Study of Efficacy and Safety of Secukinumab in Chinese Subjects With Active PsA Compared to Placebo.
The purpose of this study was to assess the efficacy and safety of secukinumab in Chinese participants with active Psoriatic arthritis (PsA ) compared to placebo.
- Trial name
- NCT04711902
- Testing
- AIN457
- Where
- 12 sites in China
- Volunteers
- 41 people
- Sponsor
- Novartis Pharmaceuticals
Seronegative Spondyloarthropathies
Combination Disease-Modifying Antirheumatic Drugs (DMARDs) Versus Sulfasalazine in Inflammatory Back Pain
Till now no drug has been conclusively shown to affect the natural course of the inflammatory back ache in seronegative spondylarthropathies.
- Trial name
- NCT01040195
- Testing
- Methotrexate, Hydroxychloroquine
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Scoliosis, Kyphosis
Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery
Individuals who undergo spine surgery often have a significant loss of blood and may require multiple blood transfusions. Research has shown that epsilon-aminocaproic acid (EACA) may reduce the amount of blood lost during…
- Conditions
- Scoliosis, Kyphosis, Lordosis, Spondylitis
- Trial name
- NCT00320619
- Testing
- Epsilon-Aminocaproic Acid (EACA)
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Psoriatic Arthritis
Metformin in Psoriatic Arthritis
Psoriatic arthritis (PsA) is a systemic, inflammatory disease. The chronic inflammation in PsA predisposes patients to the metabolic syndrome (MetS). MetS is associated with systemic inflammation and proinflammatory cytokines.
- Trial name
- NCT02188654
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- University of Alexandria
Inflammatory Bowel Disease (IBD), Spondylarthropathies
Prevelance of Axial Spondylosis Arthritis in Inflammatory Bowel Disease and Its RESPONSE to Tumour Necrosis Factor (TNF) Inhibitors Treatment in Assiut University Hospital
Prevelance of axial spondylosis arthritis in inflammatory bowel disease and its RESPONSE to tumour necrosis factor (TNF) inhibitors TREATMENT
- Conditions
- Inflammatory Bowel Disease (IBD), Spondylarthropathies, TNF-alpha Inhibitors
- Trial name
- NCT06601595
- Testing
- TNF inhibitors, conventional ibd medical treatment
- Volunteers
- 100 people
- Sponsor
- Mohamed Nasr
Spondyloarthritis, Axial, Fatigue
Fatigue and Skeletal Muscle Impact in Severe Axial Spondyloarthritis
Axial spondyloarthropathy (SpA) is the most common inflammatory rheumatism (1% of the general population) with important medico-economic consequences. Fatigue is a major feature of SA.
- Conditions
- Spondyloarthritis, Axial, Fatigue, Exercise Capacity
- Trial name
- Famuspa (NCT03940911)
- Testing
- Measurement of aerobic exercise on cycloergometer
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Strasbourg, France
Axial Spondyloarthrithis, Ankylosing Spondylitis
Study to Evaluate Maintenance of Sustained Remission of axSpA With CZP Compared to Placebo
Patients receive study drug for one year (Part A). If, after the initial run-in phase, a sustained remission is reached they will be randomly split into one of three dose groups for another year (Part B).
- Trial name
- C-OPTIMISE (NCT02505542)
- Testing
- Certolizumab Pegol
- Where
- 108 sites in United States, Belgium and 12 more
- Volunteers
- 736 people
- Sponsor
- UCB BIOSCIENCES GmbH
Osteoarthritis, Spinal Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for OA
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously and intraarticularly for the treatment of Osteoarthritis.
- Trial name
- NCT05147675
- Testing
- AlloRx
- Where
- 2 sites in United States, Greece
- Volunteers
- 92 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Psoriatic Arthritis
Clinical Study of Efficacy and Safety of BCD-085 (Monoclonal Anti-IL-17 Antibody) in Psoriatic Arthritis
Study BCD-085-8/PATERA is a multicentre double-blind placebo-controlled Phase 3 study in patients with psoriatic arthritis (PsA).
- Trial name
- PATERA (NCT03598751)
- Testing
- BCD-085
- Where
- 3 sites in Belarus, Russia
- Volunteers
- 194 people
- Sponsor
- Biocad
Axial Spondyloarthritis
Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by inflammatory arthritis and enthesitis involving the spine. AxSpA prevalence is around 0.17% of the French population.
- Trial name
- ROC-SPA (NCT03445845)
- Testing
- Secukinumab, TNF blocker, blood specimen
- Where
- 35 sites in France, Monaco
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ankylosing Spondylitis, Spondyloarthritis
Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARDs
This study evaluates clinical responses and cost-effectiveness of using etanercept (ETN) and conventional synthetic Disease modifying anti-rheumatic drugs (csDMARDs) with treat-to-target strategy in ankylosing spondylitis…
- Trial name
- NCT04077957
- Testing
- Methotrexate, Sulfasalazine, Hydroxychloroquine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ankylosing Spondylitis
ABY-035 in the Treatment of Subjects With Ankylosing Spondylitis
ABY-035-204 is a clinical study to assess the efficacy of IL-17 blocker ABY-035 in ankylosing spondylitis(AS). The primary objective is to estimate the relationship between different dose regimens of ABY-035 and clinical response…
- Trial name
- NCT04795141
- Testing
- ABY-035
- Where
- 47 sites in United States, China and 1 more
- Volunteers
- 25 people
- Sponsor
- Inmagene LLC
Psoriasis
A Randomized, Open, Parallel, Controlled, Multi-center, Interventional, Cross-sectional Study to Evaluate the Detection Rate of Psoriatic Arthritis in Korean Moderate-to-severe Psoriasis Patients, With or Without Active Screening for Arthritis in Psoriasis (ASAP Study)
This was a randomized, open, parallel, controlled, multi-center, interventional, cross-sectional study to evaluate the detection rate of Psoriatic arthritis (PsA) in Korean moderate to severe Psoriasis (PsO) patients with or…
- Trial name
- ASAP (NCT05758402)
- Testing
- Routine practice group, EARP group
- Where
- 15 sites in South Korea
- Volunteers
- 368 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis
The Effect of Psoriatic Arthritis on Female Sexual Dysfunction
Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.
- Trial name
- NCT06370221
- Testing
- The effect of psoriatic Arthritis
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Spondyloarthritis, Crohn's Disease
Effectiveness and Safety of Spondylitis Related to Inflammatory Bowel Disease
Adalimumab is an antibody treatment that targets and neutralizes a molecule produced in the body that is associated with inflammation, tumor necrosis factor (TNF).
- Trial name
- NCT00972218
- Testing
- Adalimumab
- Where
- Canada
- Sponsor
- University of Alberta
Arthritis, Psoriatic
A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis
The primary purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
- Trial name
- NCT03158285
- Testing
- Guselkumab
- Where
- 138 sites in United States, Bulgaria and 11 more
- Volunteers
- 741 people
- Sponsor
- Janssen Research & Development, LLC
Psoriatic Arthritis
Study Evaluating Anxiety and Depression in Patients With Psoriatic Arthritis
This is an epidemiological non-interventional study assessing the prevalence of anxiety and/or depression disorders in patients suffering from Psoriatic Arthritis (PsA) in Spain.
- Trial name
- NCT00884468
- Where
- Spain
- Volunteers
- 384 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis (RA, Psoriatic Arthritis (PsA
Efficacy Of Upadacitinib In Psoriatic Arthritis And Comparison To Rheumatoid Arthritis.
The general objective of the OPTIMA study is to assess the time course and interrelationship of imaging (ultrasound and magnetic resonance imaging), clinical, laboratory, and Patient Reported Outcome variables in patients with…
- Trial name
- OPTIMA (NCT06630715)
- Testing
- Upadacitinib 15 MG [Rinvoq]
- Where
- 14 sites in Italy
- Volunteers
- 178 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Ankylosing Spondylitis
NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis
To evaluate the impact of treatment with a non-steroidal anti-inflammatory drug (NSAID) - Celecoxib - when added to anti-tumour necrosis factor (TNF) therapy - Golimumab - as compared to anti-TNF therapy (Golimumab) alone on…
- Trial name
- CONSUL (NCT02758782)
- Testing
- Golimumab, Celecoxib
- Where
- 19 sites in Germany
- Volunteers
- 156 people
- Sponsor
- Charite University, Berlin, Germany
Ankylosing Spondylitis
The Effects of Baduanjin Qigong Exercise on Ankylosing Spondylitis: A Randomized Controlled Study
The aim of this study is to examine the effectiveness of 12-week Baduanjin qigong exercises in patients with ankylosing spondylitis. 59 volunteer individuals, ages 18-64, will be included in the study.
- Trial name
- NCT05771376
- Testing
- Qigong exercise program, Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
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