Clinical trials: Spine Osteoarthritis
Psoriatic Arthritis
Study of Efficacy and Safety of Brodalumab in Subjects With Psoriatic Arthritis
The primary objective of this study is to evaluate the efficacy of brodalumab, compared to placebo, in subjects with psoriatic arthritis.
- Trial name
- AMVISION-2 (NCT02024646)
- Testing
- 210 mg brodalumab, 140 mg brodalumab
- Where
- 103 sites in United States, Canada and 8 more
- Volunteers
- 484 people
- Sponsor
- Bausch Health Americas, Inc.
Ankylosing Spondylitis, Yoga
The Effects of Yoga Training in Ankylosing Spondylitis Patients
The aim of the study is to investigate the effect of yoga training on functional level, disease activity, spinal mobility, balance, sleep quality, depression and quality of life in AS patients.
- Trial name
- NCT04281238
- Testing
- Yoga group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dokuz Eylul University
Axial Spondyloarthritis
Clinical Trial of TCM Collaborative Care Model in Axial Spondyloarthritis
A pragmatic, prospective, randomized controlled trial will be conducted in patients with axial spondyloarthritis who are NSAID inadequate responders.
- Trial name
- AcuSpA (NCT03420404)
- Testing
- TCM physician involved collaborative care model (TCMCMC)
- Where
- Singapore
- Volunteers
- 140 people
- Sponsor
- Singapore General Hospital
Psoriatic Arthritis
Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis
The purpose of this study is: To elucidate the immunomodulating properties of anti-TNF-α therapy in patients with psoriatic arthritis (PsA).
- Trial name
- NCT00432406
- Testing
- Infliximab, Etanercept
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis
Patient Observational Pain and Activity Survey (POPAS) Study Using RS-4i Sequential Stimulator With Intersperse Technology in Axial Spine and Peripheral Joint Pain
Spine pain and joint pain are among the most common worldwide ailments and directly contributes to disability as well as increased duration of care.
- Trial name
- NCT05478265
- Testing
- RS-4i Plus
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Psoriatic Arthritis
Psoriatic Arthritis Research Collaborative: Biologic Sub-Study
Psoriatic arthritis (PsA) is an inflammatory arthritis with substantial variation in clinical features. We propose a multicenter collaborative approach to better understand the phenotypes and current management of PsA in the…
- Trial name
- PARC-B (NCT03378336)
- Where
- 4 sites in United States
- Volunteers
- 171 people
- Sponsor
- University of Pennsylvania
Psoriasis, Psoriatic Arthritis
Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence…
- Trial name
- CYNEPSA (NCT05307809)
- Testing
- Blood sample collection, Skin sample collection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Spondylarthropathies; Spondylitis, Ankylosing
Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082)
The study is intended to provide additional post-marketing safety data regarding the use of etoricoxib for the indication of ankylosing spondylitis.
- Trial name
- NCT01327638
- Testing
- etoricoxib, Other COX-2 inhibitor, nsNSAIDs
- Volunteers
- 21,108 people
- Sponsor
- Organon and Co
Ankylosing Spondylitis
Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients
To identify new candidate genes and proteins that are differentially expressed in responders' vs non-responders to anti-TNF alpha therapy at the several time points the investigators will use the transcriptomic and proteomic…
- Trial name
- NCT02492217
- Testing
- Adalimumab
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- Universidade Nova de Lisboa
Radiographic Axial Spondyloarthritis
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip…
- Trial name
- NCT07133633
- Testing
- Tulisokibart
- Where
- 107 sites in United States, Brazil and 12 more
- Volunteers
- 315 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Placebo and an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis
This is a study to compare the efficacy of bimekizumab versus placebo and an active comparator in the treatment of subjects with moderate to severe chronic plaque psoriasis (PSO).
- Conditions
- Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis, Psoriatic Arthritis
- Trial name
- BE VIVID (NCT03370133)
- Testing
- Bimekizumab, Ustekinumab
- Where
- 105 sites in United States, Australia and 9 more
- Volunteers
- 567 people
- Sponsor
- UCB Biopharma SRL
Spondylarthritis, Uveitis, Anterior
Observational Prospective Turkish Inception Cohort of Uveitis and Spondyloarthritis
Spondyloarthritis (SpA) encompasses a group of inflammatory rheumatic diseases characterized by axial and/or peripheral arthritis, along with extra-articular manifestations such as enthesitis, dactylitis, uveitis, and skin…
- Trial name
- OPTICUS (NCT06720376)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Arthritis, Psoriatic
A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis
This is a study to demonstrate the long-term safety, tolerability and clinical efficacy of sonelokimab in the treatment of patients with psoriatic arthritis who completed a parental study (M1095-PSA-301 or M1095-PSA-302)
- Trial name
- NCT07223138
- Testing
- Sonelokimab
- Where
- 17 sites in United States
- Volunteers
- 1,560 people
- Sponsor
- MoonLake Immunotherapeutics AG
Psoriatic Arthritis
A Study to Evaluate the Impact of Apremilast on Magnetic Resonance Imaging (MRI) Outcomes in Adults With Psoriatic Arthritis
This study is designed to assess the efficacy of apremilast, either in monotherapy or with stable methotrexate, on imaging outcomes in adults with active psoriatic arthritis with less than 5 years of disease duration (since…
- Trial name
- MOSAIC (NCT03783026)
- Testing
- Apremilast
- Where
- 36 sites in United States, Austria and 9 more
- Volunteers
- 123 people
- Sponsor
- Amgen
Psoriatic Arthritis
Evaluation of Patient Satisfaction and Therapeutic Impact Regarding Joint Consultation Rheumatologist/Dermatologist
Current increase in the number of multidisciplinary consultations, but little documentation on their impact on patient management.
- Trial name
- RHUMPSO (NCT04800289)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier le Mans
Lumbar Osteoarthritis
Primary Osteoarthritis Lumbar Spine: Establishing Its Cause, Pathogenesis and Treatment.
The study was about a root cause of Primary Osteoarthritis Lumbar Spine producing disabilities in sitting, climbing and walking etc. In advance stage the person is bereft of his/her personal physical activities.
- Trial name
- NCT05693415
- Where
- 6 sites in India
- Volunteers
- 154 people
- Sponsor
- Knee Pain Clinic
Axial Spondyloarthritis (AxSpA)
Multimodal Pulmonary Rehabilitation in Radiographic Axial Spondyloarthritis
This prospective pilot study aims to evaluate the efficacy of a structured 8-week multimodal pulmonary rehabilitation (PR) program specifically designed for patients with radiographic axial spondyloarthritis (r-axSpA).
- Trial name
- PuRe-axSpA (NCT07430189)
- Testing
- Multimodal Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Balikesir University
Ankylosing Spondylitis
Investigating the Use of Salaso to Improve Physiotherapy Management of Ankylosing Spondylitis (AS).
This is a pilot study to investigate the use of Salaso, a web based exercise app, to increase access to physiotherapy and improve physical activity in patients attending St James's Hospital Rheumatology for Ankylosing Spondylitis…
- Trial name
- NCT03457285
- Testing
- Physiotherapy
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- St. James's Hospital, Ireland
Arthritis, Psoriatic
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate the efficacy of icotrokinra (JNJ-77242113) compared to placebo in biologic-experienced and biologic-naive participants with active psoriatic arthritis (PsA) by assessing the reduction in…
- Trial name
- ICONIC-PsA 2 (NCT06807424)
- Testing
- Icotrokinra
- Where
- 236 sites in United States, Argentina and 22 more
- Volunteers
- 813 people
- Sponsor
- Janssen Research & Development, LLC
Spondylitis, Ankylosing
Evaluation of Efficacy and Safety of Meloxicam Suppository (15mg Daily) and Tablet (15 mg Daily) Compared to Indomethacin Suppository (50 mg Daily) in Patients With Ankylosing Spondylitis
Study to assess the efficacy and safety of meloxicam suppository 15 mg once daily, meloxicam tablet 15 mg once daily compared with Indomethacin suppository (50 mg daily) in patients with ankylosing spondylitis
- Trial name
- NCT02183168
- Testing
- Meloxicam suppository, Meloxicam tablet, Indomethacin
- Volunteers
- 192 people
- Sponsor
- Boehringer Ingelheim
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