Clinical trials: Spine Osteoarthritis
Spondylarthropathies, Ankylosing Spondylitis
TNFalfa Blocking Treatment of Spondylarthropathies
The purpose of the study is to establish a Danish cohort of spondylarthropathy (SpA) patients who are being treated with TNFalfa blockers.
- Conditions
- Spondylarthropathies, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT00133315
- Testing
- Infliximab, Etanercept, Adalimumab
- Where
- 9 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
COVID-19 VaccinE Response in Rheumatology Patients
The COVID-19 VaccinE Response in Rheumatology patients (COVER) study is a multicenter randomized controlled trial designed to evaluate the efficacy and safety of a mRNA COVID-19 vaccine supplemental dose (booster) in patients…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
- Trial name
- COVER (NCT05080218)
- Testing
- Upadacitinib, Abatacept, Secukinumab
- Where
- 8 sites in United States
- Volunteers
- 841 people
- Sponsor
- Jeffrey Curtis
Systemic Lupus Erthematosus, Sjogren's Syndrome
Mass Spectrometry-based Immune Profiling in Autoimmune Diseases
Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an…
- Conditions
- Systemic Lupus Erthematosus, Sjogren's Syndrome, Inflammatory Myopathies, Systemic Sclerosis (SSc)
- Trial name
- NCT07188285
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis, Spondylarthropathy
Effects of Different Antirheumatic Treatments of Arthritis on Antibody Response Following Vaccination Using Prevenar®
Previous studies have analyzed serological responses following pneumococcal vaccination using 23-valent vaccination (Pneumovax) in Rheumatoid Arthritis (RA) patients that were on different therapeutic modalities including…
- Trial name
- PVA (NCT00828997)
- Testing
- Prevenar vaccination
- Where
- Sweden
- Volunteers
- 505 people
- Sponsor
- Region Skane
Spondylitis, Ankylosing Spondylitis
Genetics of Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis.
- Trial name
- NCT00081562
- Where
- 2 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Psoriasis, Psoriatic Arthritis
Prevalence and Incidence of Articular Symptoms and Signs Related to Psoriatic Arthritis in Patients With Psoriasis Severe or Moderate With Adalimumab Treatment
Psoriatic Arthritis (PsA) is a comorbidity that affects a significant proportion of participants with moderate or severe psoriasis.
- Trial name
- TOGETHER (NCT01316224)
- Where
- 15 sites in Colombia
- Volunteers
- 52 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
SARS-CoV Infection, Systemic Disease
Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases
An observational study aiming to assess the serological profile of SARS-Cov2 patients with systemic diseases such as systemic lupus erythematosus, Sjogren syndrome, sarcoidosis, inflammatory myopathies, Behçet's disease…
- Conditions
- SARS-CoV Infection, Systemic Disease, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT04530461
- Testing
- Serological test
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- faida agili
Rheumatoid Arthritis
CorEvitas Rheumatoid Arthritis (RA) Drug Safety & Effectiveness Registry
This prospective, non-interventional research registry is designed to study the comparative effectiveness and comparative safety of approved treatments for RA in a cohort of patients cared for by rheumatologists across North…
- Trial name
- NCT01402661
- Where
- United States
- Volunteers
- 91,758 people
- Sponsor
- CorEvitas
Autoimmune Diseases
A Study to Evaluate the Safety, Mode of Action and Clinical Efficacy of GSK3050002 in Subjects With Psoriatic Arthritis
Chemokine (C-C motif) ligand 20 (CCL20) is a protein involved in attracting immune cells including subsets of T cells (for example Th17 cells), B cells, natural killer cells and dendritic cells to inflamed tissues in conditions…
- Trial name
- NCT02671188
- Testing
- GSK3050002
- Where
- United Kingdom
- Sponsor
- GlaxoSmithKline
Ankylosing Spondylitis
Exercise Therapy Program in Ankylosing Spondylitis Patients
Mobility exercises are used in Ankylosing Spondylitis (AS) patients to preserve and restore axial mobility, but there are no data regarding a specific rehabilitation program that includes flexibility alone and its association…
- Trial name
- NCT01690273
- Testing
- mobility exercise, mobility and elastic resistance exercise
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Sao Paulo
Psoriatic Arthritis
Efficacy of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis
This was a randomized, double-blind, active controlled, multicenter, parallel-group study evaluating secukinumab monotherapy and adalimumab monotherapy in approximately 850 patients with active psoriatic arthritis (PsA) who are…
- Trial name
- EXCEED 1 (NCT02745080)
- Testing
- Secukinumab, Adalimumab
- Where
- 156 sites in United States, Australia and 24 more
- Volunteers
- 853 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis
Jaktinib Hydrochloride Tablets In The Treatment of Active Ankylosing Spondylitis
This trial uses a multi-center, randomized, double-blind, placebo, parallel-controlled design, and it is expected that about 105 cases will be enrolled in about 10 sites.
- Trial name
- AS (NCT04507659)
- Testing
- Jaktinib Hydrochloride Tablets
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Axial Spondyloarthritis
New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI
investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).
- Trial name
- NCT05914532
- Testing
- lab testing
- Where
- Turkey (Türkiye)
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Systemic Lupus Erythematosus
This Project Aims to Understand the Needs of Rheumatologists and Other Specialties in the Care of Patients With SLE
The project will be conducted in four distinct stages. Firstly, evidence synthesis will be carried out to gather and analyze available data on the topic.
- Trial name
- LESBRA (NCT06698900)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Axial Spondyloarthritis
Physiotherapy of Axial Spondyloarthritis
This protocol is for a pragmatic randomised controlled clinical trial (RCT) with a manual spinal mobilisation (MSM) intervention for patients with axial spondyloarthritis (axSpA), embedded in a Trials within Cohort (TwiCs)…
- Trial name
- PaxSpA (NCT04679649)
- Testing
- Manual spinal mobilisation physiotherapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Arthritis, Rheumatoid, Spondyloarthritis
Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients
Fulfilling by all patients consequently seen by 6 rheumatologists in a same outpatient rheumatology clinic (in at least one month period) of a set of 6 questionnaires, including RAPID3 and pain catastrophizing scales.
- Conditions
- Arthritis, Rheumatoid, Spondyloarthritis, Inflammatory Rheumatisms, Systemic Disorders
- Trial name
- NCT03306784
- Testing
- questionnaires
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Nantes University Hospital
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Ankylosing Spondylitis
Alexithymia in Ankylosing Spondylitis
The study included 55 patients having Ankylosing Spondylitis (AS) for at least 1 year diagnosed according to the ASAS classification criteria who presented to our hospital's outpatient clinic and 55 healthy subjects.
- Trial name
- NCT04320459
- Testing
- Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI)
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Spondyloarthropathy, Crohn Disease
The SpACE Study - Small Bowel Crohn's Disease and Spondyloarthropathies
Inflammatory bowel disease is clinically associated with spondylarthropathies in 5-15% of cases. Protocol colonoscopic assessment demonstrated asymptomatic inflammation characteristic of Crohn's disease in up to 1/3 of SpA…
- Trial name
- SpACE (NCT03064815)
- Testing
- Videocapsule endoscopy, colonoscopy, PROMETHEUS® IBD sgi Diagnostic™
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Spondylarthritis, Inflammatory Bowel Diseases
Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease
The QUESAM study aims to translate into French and validate the traduction of 2 screening questionnaires for spondylo-arthritis among people with inflammatory bowel disease.
- Conditions
- Spondylarthritis, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- QUESAM (NCT06998316)
- Testing
- Screening questionnaire
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Grenoble
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