Clinical trials: Spine Surgeries
Spinal Disorders, Degenerative Spine Disease
Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in Multilevel Thoracolumbar Spinal Surgery
Multilevel spinal stabilization surgery is frequently associated with substantial blood loss and increased transfusion requirements.
- Conditions
- Spinal Disorders, Degenerative Spine Disease, Blood Loss, Surgical
- Trial name
- NCT07288697
- Testing
- low-dose TXA, high-dose TXA
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Chronic Low Back Pain, After Lumbar Spine Surgery
Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery
Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects.
- Conditions
- Chronic Low Back Pain, After Lumbar Spine Surgery, Failed Back Surgery Syndrome (FBSS)
- Trial name
- NCT07576062
- Testing
- CFT
- Volunteers
- 90 people
- Sponsor
- Centro Universitário Augusto Motta
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery
Introduction: Improving postoperative pain management after spinal surgery is a significant challenge for surgeons and anesthesiologists.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spine Instability
- Trial name
- NCT05871073
- Testing
- Ropivacaine 0.75% Injectable Solution, dexamethasone 8mg
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Hospital Fattouma Bourguiba
Hypoxia
The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
The area of aesthesia-induced atelectasis is much larger in the obese compared with the non-obese, but there may also be more airway closure and impaired matching of ventilation and lung blood flow.
- Trial name
- NCT02961920
- Testing
- IE ratio 1:1, IE ratio 1:2
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Gachon University Gil Medical Center
Spine Surgery, Vision Impairment
Intraocular Pressure During Prone Spinal Surgery
Postoperative visual loss resulting from surgical procedures not performed on the eye is a devastating outcome for the patient and poorly understood by the medical community. It is potentially a preventable complication.
- Trial name
- NCT00176722
- Testing
- table tilt
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Spinal Stenosis, Spondylolisthesis
ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion
The recent development and expansion of endoscopic surgery has made it possible to offer an alternative to this therapeutic escalation.
- Trial name
- ESCAPE (NCT06950853)
- Where
- 13 sites in France
- Volunteers
- 375 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Pain, Breast Surgery
Injection Rate and Erector Spinae Plane Block
To evaluate the effect of injection rate on the block sensory level in the ESP block.
- Trial name
- NCT04895072
- Testing
- Standard group, Long group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Antalya Training and Research Hospital
Postoperative Pain, Spine Deformity
Intraoperative Placement of Superficial Erector Spinae Plane Block; A New Approach in Spine Surgery
Major spine surgery causes severe postoperative pain. The primary objective of this randomized controlled study is to compare the effect of ultrasound (US)-guided superficial erector spinae plane (ESP) block on 48-hour…
- Conditions
- Postoperative Pain, Spine Deformity, Spine Injury, Spine Fracture
- Trial name
- NCT05244031
- Testing
- superficial erector spina plane block, Standard (opioid-based) analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Spinal Fusion
The Effects of Dexmedetomidine Dose on Motor Evoked Potentials
This a parallel group, two-arm, randomized superiority trial that will compare the effect of two different doses of dexmedetomidine on motor evoked potentials during spine surgery
- Trial name
- NCT03378973
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Spine Degeneration, Economic Problems
Cost-effectiveness Analysis of Robot-assisted Spinal Surgery
With the change of lifestyle and the aging of the population, the prevalence of Lumbar disc herniation (LDH) in my country is increasing year by year, and surgery is one of the main ways to treat LDH.
- Conditions
- Lumbar Spine Degeneration, Economic Problems, Surgery
- Trial name
- NCT05388383
- Testing
- Ti-robot
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Jishuitan Hospital
Opioid Use, Spine Fusion
Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.
opioid free anesthesia consists of combination of pharmacological and non pharmacological modalities that target different pathways of pain mechanism.
- Trial name
- NCT05850468
- Testing
- fentanyl infusion after general anesthesia and erector spinea block, lidocaine 2% and dextometometidine infusion after general anesthesia and erector spinea block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Traumatic Spinal Cord Injury
The Austrian Spinal Cord Injury Study
Traumatic spinal cord injury (tSCI) is a debilitating disease that leads to neurological deficits and often has long-term effects including severe lifelong disability.
- Trial name
- ASCIS (NCT03109782)
- Where
- 18 sites in Austria
- Volunteers
- 1,000 people
- Sponsor
- Paracelsus Medical University
Spinal Stenosis, SPINAL Fracture
Evaluation of the Evolution of Patient Care Within the Spinal Pathology Department
Spinal conditions are a major public health issue. Their management by surgical treatment is constantly improving and surgical procedures or implantable medical devices are experiencing significant progress.
- Conditions
- Spinal Stenosis, SPINAL Fracture, Vertebral Osteomyelitis, Vertebral Metastasis
- Trial name
- SPINDATA (NCT07627282)
- Testing
- self-administered questionnaire
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Bordeaux
Infection After Transfusion
The Immunomodulation Effect of Blood Transfusion in Operative Spine Surgery Patients
The purpose of this study is to investigate the effect of transfusion of allogeneic (homologous) red cells on the immunologic parameters such as T-cells as well as natural killer cell count/function, various interleukins, TNF…
- Trial name
- NCT02069210
- Testing
- Blood transfusion
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Pain, Postoperative
TAP Block Efficacy After Lumbar Spine Surgery Through Anterior Approach: a Randomized, Placebo-controlled Study
Anterior Lumbar Interbody Fusion (ALIF) as well as Direct Lateral Interbody Fusion (DLIF) are established techniques for lumbar interbody fusion.
- Trial name
- TAP-LIF (NCT02778178)
- Testing
- ropivacaine plus clonidine, ultrasound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Lumbar Spinal Canal Stenosis
Irrigation Endoscopic Decompression
To evaluate a new endoscopic technique for lumbar spinal canal decompression.
- Trial name
- NCT02254590
- Testing
- Irrigation Endoscopic Decompressive Laminotomy
- Volunteers
- 104 people
- Sponsor
- Cairo University
Opioid Withdrawal, Postoperative Pain
Opioid Tapering After Spine Surgery
The effect of a tapering plan combined with telephone counselling to assist patients in opioid tapering after surgery remains unexplored.
- Trial name
- NCT04140955
- Testing
- Tapering plan and telephone counselling
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Lumbar Disc Herniation, Postoperative Pain
Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery
This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block.
- Trial name
- TLIP-QIP (NCT07750418)
- Testing
- Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Quadratus Lumborum-Iliac Plane (QIP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Vezirköprü State Hospital
Adults, No Sagittal Spine Disposition Disorder
Xiaxi Program for Back Health
Progressive deformity from the optimal spinal curvatures is a degenerative disorder related to progressive ageing that affects an increasing number of adults.
- Conditions
- Adults, No Sagittal Spine Disposition Disorder, No Surgery on the Spine or the Hamstring, No Specific Treatment for Spinal Pathology
- Trial name
- NCT06042218
- Testing
- Xiaxi intervention program
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia