Clinical trials: Spine Surgeries
Spondyloarthrosis, Spondylosis
Study Confirms or Refutes the Hypothesis That the Autologous Bone Marrow Concentrate Together With the Allograft is a Better Alternative for the Posterolateral Fusion in Spine Surgery Than the Allograft Alone
The use of autologous mesenchymal stem cell (MSCs) in form of the BMC in combination with allograft is an effective option how to enhance the Posterolateral Fusion (PLF) healing.
- Trial name
- NCT01603836
- Testing
- bone allogaft with bone marrow concentrate
- Volunteers
- 80 people
- Sponsor
- Hospital Znojmo
Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit
Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper Prime
The Viper Prime/Expedium spine systems are intended to provide immobilization and stabilization of spinal segments in skeletally mature patients as an adjunct to fusion in the treatment of acute and chronic instabilities or…
- Conditions
- Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit, Degeneration of Lumbar Intervertebral Disc
- Trial name
- NCT06704906
- Testing
- Use of Viper Prime/Expedium system with Fibergraft BG Putty
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nitin Agarwal
Inflammation
Effect of Dexamethasone on Postoperative Inflammatory Factors
This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the…
- Trial name
- NCT04981093
- Testing
- Dexamethasone Injection, Normal saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Ningxia Medical University
Post-surgical Pain
Effects of Music Therapy on the Recovery of Patients Undergoing Spine Surgery
The investigators are studying music therapy as an incentive and adjunct to a comprehensive spine surgery rehabilitation-recuperation program.
- Trial name
- NCT02145221
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Beth Israel Medical Center
Deep Surgical Site Infection, Spine Surgery
Risk Factors Associated With Infection After Spine Surgery
Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important…
- Trial name
- NCT05740865
- Testing
- open posterior instrumented thoracolumbar surgery
- Where
- China
- Volunteers
- 3,419 people
- Sponsor
- Xuanwu Hospital, Beijing
Posterior Lumbosacral Spine Fixation Surgeries
Dexmedetomidine Combined With Bupivacaine for Erector Spinae Plane Block
As the posterior lumbosacral spine fixation surgeries are common spine procedures done nowadays due to different causes and as this spine procedure is mostly accompanied with moderate to severe postoperative pain, so it is…
- Trial name
- NCT05590234
- Testing
- Dexmedetomidine injection, Bupivacaine 0.25% Injectable Solution, normal saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- October 6 University
Degenerative Disc Disease, Spondylolisthesis
Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery
This is a pilot study to evaulate the safety and prelimary effectiveness of Prefix as compared to autogenous bone for spinal fusion procedures in skeletally mature subjects with degenerative disc disease (DDD) at one level from…
- Trial name
- NCT00798239
- Testing
- Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
- Where
- 5 sites in Canada
- Volunteers
- 24 people
- Sponsor
- BioSurface Engineering Technologies, Inc
Anesthesia
Effect of Aminophylline Bolus Versus Infusion on Recovery Time in Patients Undergoing Lumbar Spine Surgery
To determine optimal dose, method and time of administration of aminophylline to enhance the recovery from general anesthesia. andTo estimate the recovery time from isoflurane closure in each group.
- Trial name
- NCT05655806
- Testing
- Aminophylline bolus then infusion, aminophylline bolus, normal saline
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Cairo University
S-ketamine, Postoperative Analgesia
Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Despite opioid-based multimodal analgesia, moderate-to-severe pain remains a big problem in patients following multi-segment spinal fusion.
- Conditions
- S-ketamine, Postoperative Analgesia, Spine Fusion
- Trial name
- NCT04964219
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Postextubation Stridor
Airway Ultrasound as a Predictor for Postextubation Stridor in Anterior Cervical Spine Surgery
literature on use of the ultrasound (US) in extubation decisions in cervical spine surgery is scarce.The aim of this study will be to evaluate the utility of US as an aid for decision making for extubation in elective cervical…
- Trial name
- NCT03764904
- Testing
- Airway Ultrasound
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Spinal Stenosis Lumbar, Disc Degeneration
Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF
Researchers are considering Dexamethasone as preemptive medication before minimally invasive spine fusion surgery to minimize postoperative back pain with minimal side effects, aiming to enhance the effectiveness of surgery and…
- Conditions
- Spinal Stenosis Lumbar, Disc Degeneration, Disc Disease, Fusion of Spine
- Trial name
- MIS-TLIF (NCT06367855)
- Testing
- Dexamethasone, Normal saline
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Potsawat Surabotsopon
Lumbar Spine Degeneration, Physical Disability
Delphi Study on Rehabilitation Following Lumbar Arthrodesis
Delphi study on perioperative rehabilitation after single and double level lumbar arthrodesis.
- Conditions
- Lumbar Spine Degeneration, Physical Disability, Surgery
- Trial name
- NCT03427294
- Testing
- Delphi study
- Where
- Belgium
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spine Diseases
Awakening in Spine Surgery: A Comparison Between Clinical Signs and Bispectral Index
BIS is one of several equipments used to monitor depth of anesthesia.Some studies found BIS can reduce total propofol dose when being used with target controlled infusion (TCI).The objective is to compare awakening time after…
- Trial name
- NCT02174913
- Testing
- bispectral index, Target controlled infusion of propofol, Fentanyl
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery
Introduction: Improving postoperative pain management after spinal surgery is a significant challenge for surgeons and anesthesiologists.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spine Instability
- Trial name
- NCT05871073
- Testing
- Ropivacaine 0.75% Injectable Solution, dexamethasone 8mg
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Hospital Fattouma Bourguiba
Dysphagia After Anterior Cervical Decompression and Fusion of the Spine
Effect of Intravenous Corticosteroid Injections on Dysphagia After Cervical Spine Surgery
This is a randomized, double-blind, placebo-controlled study to examine the effect of local intravenous steroids following anterior cervical spine surgery on the development of dysphagia in patients.
- Trial name
- NCT02266797
- Testing
- Dexamethasone, Saline
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Atelectases, Postoperative Pulmonary, Prone Position
ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound
Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia.
- Conditions
- Atelectases, Postoperative Pulmonary, Prone Position, Spine Surgery, Lung Ultrasound
- Trial name
- NCT07375173
- Testing
- Titrated Oxygen, Fixed oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Etlik City Hospital
Spinal Diseases
The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery.
The purpose of this study is to evaluate the effectiveness of perioperative Lidocaine intravenous infusion in reducing postoperative pain for spine surgery patients.
- Trial name
- NCT02762656
- Testing
- Lidocaine
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Symptomatic Cervical Disc Disease
Safety and Efficacy Study Comparing ProDisc-C to ACDF Surgery to Treat SCDD
The objective of this clinical investigation is to compare the safety and effectiveness of ProDisc-C to anterior cervical discectomy and fusion (ACDF) surgery in the treatment of symptomatic cervical disc disease (SCDD).
- Trial name
- NCT00291018
- Testing
- Total Disc Replacement, ACDF
- Volunteers
- 368 people
- Sponsor
- Synthes USA HQ, Inc.