Clinical trials: Spine Surgeries
Low Back Pain, Lumbar Spine Injury
Second Opinion in Spinal Surgery Indications: Cost-Effectiveness Evaluation
Low back pain is a common symptom, which often affects the adult population. Studies show that over the past two decades, costs related to spinal surgery have increased significantly, leading to speculation about what would be…
- Trial name
- NCT03082248
- Testing
- Physical Therapy, Spinal Surgery
- Where
- Brazil
- Volunteers
- 190 people
- Sponsor
- Hospital Israelita Albert Einstein
Spondylolisthesis, Spinal Stenosis
Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis
This study tests the effectiveness of different treatments for the three most commonly diagnosed conditions of the lower backbone (lumbar spine).
- Conditions
- Spondylolisthesis, Spinal Stenosis, Low Back Pain
- Trial name
- SPORT (NCT00000409)
- Testing
- Decompressive laminectomy, Non-surgical treatments, Fusion--Instrumented
- Where
- 13 sites in United States
- Volunteers
- 304 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Thoracolumbar Burst Fracture
Thoracolumbar Burst Fractures Study Comparing Surgical Versus Non-surgical Treatment
Thoracolumbar (TL) burst fractures in neurologically intact patients account for approximately 45% of all TL spine injuries. Despite being common fractures, there is significant variability in treatment recommendations…
- Trial name
- NCT02827214
- Where
- 14 sites in United States, Australia and 8 more
- Volunteers
- 213 people
- Sponsor
- AO Innovation Translation Center
Spinal Disease
Prospective Robotic-Guided Registry of Spine Surgery
This study aims to combine multi-center data of robotic assisted spine surgery, to evaluate the true scope of this advancing technology.
- Trial name
- PRoGRSS (NCT05181098)
- Testing
- Robotic-guided spine surgery
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- The National Spine Health Foundation
Opioid Use, Spine Fusion
Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.
opioid free anesthesia consists of combination of pharmacological and non pharmacological modalities that target different pathways of pain mechanism.
- Trial name
- NCT05850468
- Testing
- fentanyl infusion after general anesthesia and erector spinea block, lidocaine 2% and dextometometidine infusion after general anesthesia and erector spinea block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Adolescent Idiopathic Scoliosis, Cerebral Palsy
Pain Assessment in Children Undergoing Spine Surgery
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain conditions have a major impact on the daily lives.
- Trial name
- NCT04244760
- Testing
- Pain assessment for verbal patients, Pain assessment for non-verbal patients
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Catherine Ferland
Thoracolumbar Spine
Screening for Kyphosis in the Mean Term in Patients Treated With Kyphoplasty Alone in the Management of Stable Traumatic Compression Fractures of the Thoracolumbar Spine
The aim of this retrospective study is to show that kyphoplasty is a reliable technique in the treatment of certain traumatic vertebral fractures.
- Trial name
- KIPHO (NCT02085811)
- Testing
- radiography standard
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Surgical Wound, Orthopedic Disorder of Spine
Local Wound Anesthesia in Spine Surgery
Prospective, randomized, double-blinded, trial regarding the effect of local wound infiltration at the end of spine surgery; randomizing 1:1:1 between NaCl, Ropivacain, Levobupivacaine combined with Tramadol
- Trial name
- NCT05693454
- Testing
- Infiltration with NaCl, Infiltration with Ropivacain, Infiltration with a combination of Levobupivacaine and Tramadol
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Balgrist University Hospital
Spine Fusion, Spine Disease
Erector Spinae Plane Block for Cervical Spine Surgery
The study aims to assess the interfacial plane blocks' effect on pain level, course of postoperative rehabilitation, and anti-inflammatory analgesic effect.
- Conditions
- Spine Fusion, Spine Disease, Spinal Disease
- Trial name
- NCT06393530
- Testing
- 0.9%sodium chloride, 0.2% ropivacaine
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Scoliosis, Spine Deformity
Post-Hoc Cost-Utility Analysis of Ultrasound-Guided Erector Spinae Plane (ESP) Block Versus Total Intravenous Anesthesia (TIVA) in Posterior Scoliosis Correction Surgery: Evidence From the Egyptian EQ-5D-5L Value Set
Posterior scoliosis correction surgery is associated with sever postoperative pain that necessitate high perioperative opioid doses to alleviate pain .
- Trial name
- NCT07470567
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- National Bank Hospital
Post Operative Analgesia
ERECTOR SPINAE BLOCK AFTER THORACIC SPINE SURGERY
the effectiveness of ultrasound guided erector spinae plane block in patients undergoing thoracic spine sugery
- Trial name
- SPINE (NCT04449367)
- Testing
- ultrasound guided erector spinae plane block
- Where
- United Arab Emirates
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dubai Health Authority
ERAS
Enhanced Recovery After Spine Surgery Randomized Clinical Trial
The purpose of this study is to compare two different approaches to the care patients receive before, during and after their spinal surgery and to determine if either approach has a significant difference in patient outcomes…
- Trial name
- ERASS (NCT05830331)
- Testing
- ERASS Pathway
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- University of Pennsylvania
Patient Blood Management
Impact of Patient Blood Management (PBM) at the Schulthess Clinic
Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at…
- Trial name
- PBM (NCT06363214)
- Testing
- Patient blood management
- Volunteers
- 16,000 people
- Sponsor
- Schulthess Klinik
Opioid Withdrawal, Postoperative Pain
Opioid Tapering After Spine Surgery
The effect of a tapering plan combined with telephone counselling to assist patients in opioid tapering after surgery remains unexplored.
- Trial name
- NCT04140955
- Testing
- Tapering plan and telephone counselling
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Surgical Site Infection
Incisional Negative Pressure Wound Therapy in Patients Undergoing Spine Surgery
Introduction: Posterior post-operative spine wounds involving surgery at multiple levels are known to have higher rates of wound complications relative to other areas of the body.
- Trial name
- NCT03820219
- Testing
- Prevena™ system, Standard sterile wound dressing
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Nova Scotia Health Authority
Cervical Spine Surgery
Multifidus Cervicis and Inter-Semispinal Plane Blocks in Analgesia After Cervical Spine Surgery
Major spine surgery with multilevel instrumentation is followed by a large amount of opioid consumption, significant pain, and difficult mobilization Pain is one of the main factors limiting ambulation, increasing the risk of…
- Trial name
- NCT06083298
- Testing
- control group, MCP group, ISP group
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Zagazig University
Spine Deformity
Spine Deformity Patients With Optoelectronic Motion Capture
Aging-induced changes in the spine can lead to adult spinal deformity, causing a forward and/or lateral shift of the trunk. While mild cases may have compensatory mechanisms, severe deformities necessitate treatment.
- Trial name
- NCT06223737
- Testing
- EOS x-ray, Motion capture
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Schulthess Klinik
Airway Management, Endotracheal Intubation
REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring
The purpose of this research is to compare four commonly used anesthesia medication strategies for placing a breathing tube in patients undergoing spine surgery that requires motor evoked potential (MEP) monitoring.
- Trial name
- REMI-MEP (NCT07835295)
- Testing
- Low-Dose Remifentanil, High-Dose Remifentanil, Succinylcholine
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Mayo Clinic
Spine Fracture, Orthosis
ORthosis vs No Orthosis After Surgically Treated Traumatic Thoracolumbar Fractures
Rationale: There is no evidence in the current literature regarding the additional value of an orthosis after surgically treated thoracolumbar spine fractures.
- Conditions
- Spine Fracture, Orthosis, Traumatic Fracture, Posterior Fixation
- Trial name
- ORNOT (NCT03097081)
- Testing
- No orthosis, Orthosis
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol…
- Trial name
- NCT07822295
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital