Clinical trials: Spine Surgery
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Spinal Deformity
Supplemental Anterior Lumbar Interbody Fusion (ALIF) in Spinal Deformity
Within the last decade there has been an increase in the number of surgical procedures for deformities of the spine. This is caused by the increase in the elderly population, improved surgical techniques and an increased number…
- Trial name
- SALIF (NCT01601054)
- Testing
- Tantalum cage from Zimmer
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Spine Surgery
Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clinical Trial
The study aim is to show the effectiveness of a hybrid system (DTO) regarding clinical outcome and radiological alteration in a single-center prospective setting.
- Trial name
- NCT03404232
- Testing
- Dynesys DTO device (Zimmer Spine, Inc.)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Aachen
Spondyloarthrosis, Spondylosis
Study Confirms or Refutes the Hypothesis That the Autologous Bone Marrow Concentrate Together With the Allograft is a Better Alternative for the Posterolateral Fusion in Spine Surgery Than the Allograft Alone
The use of autologous mesenchymal stem cell (MSCs) in form of the BMC in combination with allograft is an effective option how to enhance the Posterolateral Fusion (PLF) healing.
- Trial name
- NCT01603836
- Testing
- bone allogaft with bone marrow concentrate
- Volunteers
- 80 people
- Sponsor
- Hospital Znojmo
Erector Spina Plan Block
The Effect of bılateral Erector spına Plan Block on postoperatıve paın ın spınal Surgery
Patients undergoing lumbar spinal stabilization surgery may experience severe postoperative pain lasting at least three days. Analgesia after lumbar stabilization surgery is beneficial for early recovery and is therefore…
- Trial name
- ESPB (NCT07537647)
- Testing
- UNDER ULTRASOUND GUİDANCE ESPB BLOCK, PROCEDURE/SURGERY: ERECTOR SPİNAE (ESP) BLOCK WİTH BUPİVACAİNE
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Hypotension
Vasopressor Outcomes in Spine Surgery
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
- Trial name
- V-SPINE (NCT06053398)
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Texas Southwestern Medical Center
Spine Surgery
Influence of Dexmedetomidine on the Evoked Potentials During Spine Surgery
The purposes of this study are: 1. To evaluate the safety and efficacy of Dexmedetomidine as an adjunct for anesthesia during spine surgery and 2. To investigate the influence of Dexmedetomidine on the evoked potentials.
- Trial name
- NCT00494832
- Testing
- Dexmedetomidine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Spine Erector, Cardiac Surgery
Comparison Erect Spine in Cardiac Surgery
Open cardiac surgeries are characterized by the increased use of opioids and longer extubation times, being post-sternotomy pain one of the causes of greater patient discomfort, plexus blockages have been used more frequently…
- Conditions
- Spine Erector, Cardiac Surgery, Acute Pain, Chronic Pain
- Trial name
- COESPINE (NCT04313959)
- Testing
- Ropivacaine 0.2% Injectable Solution, Ropivacaine 0.2% + Dexamethasone
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Instituto do Coracao
Failed Back Surgery Syndrome
Management of Pain Associated With Failed Back Surgery Syndrome
Neuropathic pain is a common complication following different types of spine surgery making negative impact on health, along with life style changes and management, many neurologist prescribed either Pregabalin or Gabapentin to…
- Trial name
- NCT05324761
- Testing
- Pregabalin 75mg, Gabapentin 300mg
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Al-Kindy College of Medicine
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis
- Trial name
- NCT05029726
- Testing
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- John O'Toole
Giant Thoracic Herniation, Myelopathy
Management of Giant Thoracic Disc Hernias by Thoracoscopy: Experience of 52 Cases
Introduction: Giant thoracic disc herniation is a rare condition for which surgical treatment is indicated when there are signs of spinal cord injury.
- Trial name
- GHTT (NCT03295617)
- Testing
- Thoracoscopy
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Hopital Foch
Lumbar Disk Herniation
Percutaneous Transforaminal Endoscopic Discectomy vs. Open Microdiscectomy for Lumbar Disc Herniation (PTED-study)
Rationale: Lumbosacral radicular syndrome (LSRS) is caused by a herniated lumbar nucleus pulposus (HNP) and the estimated annual incidence in The Netherlands ranges between 60,000 to 75,000 people.
- Trial name
- NCT02602093
- Testing
- Transforaminal Endoscopic Discectomy, Open Microdiscectomy
- Where
- Netherlands
- Volunteers
- 682 people
- Sponsor
- Amsterdam UMC, location VUmc
Degenerative Diseases, Nervous System
Performance Assessment Of The PMD-200 In Subjects With Degenerative Lumbar Spine Disease Who Requires Surgical Procedure
Performance assessment of the PMD-200, a novel pain monitor, in subjects with degenerative lumbar spine disease who requires surgical procedure
- Trial name
- NCT03389048
- Testing
- PMD-200, SLR
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Medasense Biometrics Ltd
Postoperative Pain Management
COMPARISON OF THE EFFECTS OF ERECTOR SPINAE PLANE (ESP) BLOCK AND QUADRO İLİAC PLANE (QIP) BLOCK ON POSTOPERATIVE OPIOID CONSUMPTION AND PAIN IN LUMBAR SPINAL SURGERY
COMPARISON OF THE EFFECTS OF ERECTOR SPINAE PLANE (ESP) BLOCK AND QUADRO İLİAC PLANE (QIP) BLOCK ON POSTOPERATIVE OPIOID CONSUMPTION AND PAIN IN LUMBAR SPINAL SURGERY
- Trial name
- NCT07852104
- Testing
- NRS Score, total tramadol consumption, Post Operative Pain Relievers
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Aydin Adnan Menderes University
Degenerative Cervical Myelopathy
Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot
This study is a pilot randomized clinical trial designed to test whether it is feasible to conduct a larger study comparing two standard treatments for mild degenerative cervical myelopathy (DCM).
- Trial name
- CADET-DCM (NCT07358273)
- Testing
- Decompression Surgery, Conservative Care
- Volunteers
- 56 people
- Sponsor
- McMaster University
Postoperative Pain, Spine Deformity
Intraoperative Placement of Superficial Erector Spinae Plane Block; A New Approach in Spine Surgery
Major spine surgery causes severe postoperative pain. The primary objective of this randomized controlled study is to compare the effect of ultrasound (US)-guided superficial erector spinae plane (ESP) block on 48-hour…
- Conditions
- Postoperative Pain, Spine Deformity, Spine Injury, Spine Fracture
- Trial name
- NCT05244031
- Testing
- superficial erector spina plane block, Standard (opioid-based) analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Surgery
A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.
Determine the optimal dose of IV N-acetylcysteine (NAC) to produce opioid reduction following spine surgery and estimate the difference in opioid consumption between placebo and the selected optimal dose.
- Trial name
- NCT04562597
- Testing
- Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Surgical Site Infection
The Use of Diluted Povidone Iodine Irrigation in Spine Surgery
The purpose of the study is to determine whether diluted Povidone Iodine solution used to irrigate surgical wounds during spine surgery decreases the incidence of surgical site infections.
- Trial name
- NCT01577524
- Testing
- Povidone-Iodine, Saline
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Attabib, Najmedden, M.D.
Cervical Disc Disease
Driving After Cervical Spine Surgery
This is a single-center, prospective controlled simulation study designed comparing and evaluating the driving performance of subjects who have had cervical spine surgery and the use of a validated driving simulator.
- Trial name
- NCT02782923
- Testing
- STISIM driving simulator
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health