Clinical trials: Spine Tumor, open to volunteers
Spinal Deformity, Spinal Degenerative Disorder
The Ailliance Post-Market Clinical Study
The purpose of this clinical study is to collect performance and safety data for post-market Medtronic devices indicated for cranial and/or spinal indication(s). Subjects are enrolled and followed postoperatively to 24 months.
- Conditions
- Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
- Trial name
- NCT05856370
- Testing
- Follow-up schedule: pre-operative baseline up to 24-months post-procedure
- Where
- 29 sites in United States, France and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Medtronic Spinal and Biologics
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley
Pediatric Brain Tumor, Pediatric Spine Tumor
Evaluation of the Neurologic Assessment in Pediatric Neuro-Oncology (pNANO)
This study aims to investigate a neurologic exam scale to provide an objective and more standard way to assess tumor response in pediatric patients with brain and spinal cord tumors.
- Trial name
- NCT06981156
- Testing
- pNANO Assessment
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- University of Wisconsin, Madison
Spine Tumor, Spine Metastases
Spine Oncology Registry
This is an observational study to evaluate hardware related and oncologic outcomes in adult patients with primary and metastatic spine disease undergoing separation surgery followed by radiation treatment.
- Conditions
- Spine Tumor, Spine Metastases, Spine Cancer
- Trial name
- NCT07225491
- Where
- 5 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Arthritis of Knee, Arthritis of Hip
Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy
The present study is a prospective, multi-center observational trial comparing the times taken to diagnose coagulopathies using point-of-care (POC) viscoelastic tests or standard central laboratory tests (SCL tests) in patients…
- Conditions
- Arthritis of Knee, Arthritis of Hip, Spine, Prostate Cancer
- Trial name
- NCT06637943
- Testing
- SCL tests, POC viscoelastic tests
- Where
- 4 sites in South Korea
- Volunteers
- 210 people
- Sponsor
- Konkuk University Medical Center
Spinal Metastasis
RELIEVE: Research on Effectiveness of Surgery and Radiotherapy on Relieving Spine Tumor Pain in Patients with Vertebral Metastases
This is a prospective, multicenter, observational study focusing on assessing and managing pain in patients with metastatic spinal tumors.
- Trial name
- RELIEVE (NCT06746103)
- Testing
- Surgery
- Volunteers
- 250 people
- Sponsor
- AO Foundation, AO Spine
Solid Tumor Spine Metastases
Spine SABR - Dose-escalated Stereotactic Ablative Body Radiotherapy (SABR) for Solid Tumour Spine Metastases
This study will look at treatment for patients that have already been diagnosed with cancer, but develop a new tumor(s) in the spine.
- Trial name
- Spine-SABR (NCT06078813)
- Testing
- Radiation: image guided dose escalated SABR using a simultaneous integrated boost (SIB)
- Where
- 3 sites in Ireland
- Volunteers
- 126 people
- Sponsor
- Cancer Trials Ireland
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Spinal Metastases
D20054;LITT for Spine Tumors
The objective of this clinical study is to evaluate the efficacy and safety of spinal laser interstitial therapy in the treatment of metastatic spinal tumors.
- Trial name
- NCT06548061
- Testing
- ClearPoint Prism
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cancer Metastatic
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
This study is being done to answer the following question: Is Stereotactic Body Radiation Therapy or SBRT (a form of radiation therapy which can deliver high doses of radiation to the specific painful area of the body most…
- Trial name
- NCT06391242
- Testing
- Standard Conventional Radiotherapy, Stereotactic Body Radiotherapy
- Where
- 12 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Canadian Cancer Trials Group
Neoplasm Metastases, Metastases, Neoplasm
Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas
The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% in painful non-spinal bone metastases.
- Trial name
- NCT05419518
- Testing
- EXTERNAL BEAM RADIATION
- Where
- 7 sites in United States
- Volunteers
- 124 people
- Sponsor
- Rutgers, The State University of New Jersey
Metastatic Neoplasm to the Spine, Metastatic Neoplasm
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic…
- Trial name
- SPORTSMEN (NCT05617716)
- Testing
- Conventional external beam radiation therapy dose (EBRT), Spine radiosurgery/stereotactic body radiation therapy standard dose, Spine radiosurgery/stereotactic body radiation therapy high dose
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
Bone Tumor, Osteoporosis
U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures
The goal of this investigational device exemption is to evaluate the Epione assistance for introducer placement during percutaneous procedures in musculo-skeletic (MSK) structures of the pelvis and the spine in adults.
- Conditions
- Bone Tumor, Osteoporosis, Traumatic Fracture
- Trial name
- EPIOS (NCT07325578)
- Testing
- Percutaneous procedure in the MSK structures of the pelvis and/or the spine
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Precision IO Group
Spinal Tumors
Liquid Biopsy Following BBB Disruption Using Barrier Disrupting Fields in Patients Undergoing Spine Surgery
Objective: To identify new central nervous system (CNS) biomarkers to be used for blood-derived liquid biopsy once the blood-brain barrier (BBB), specifically the blood-arachnoid barrier (BAB), has been transiently disrupted by…
- Trial name
- BDF002 (NCT07224451)
- Testing
- spinal surgery, BDF
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Spine Fusion, Spine Tumor
Effect of Ketamine on Intraoperative Motor Evoked Potentials
The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic.
- Conditions
- Spine Fusion, Spine Tumor, Spinal Stenosis
- Trial name
- NCT06140927
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Thoracic Neoplasms, Lumbar Neoplasm
Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors
This study looks at how well a combination of treatments helps reduce pain in people with tumors in the middle and lower back (thoracic and lumbar spine).
- Trial name
- NCT07479199
- Testing
- kyphoplasty with Osteocool
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Spine Fracture, Degenerative Disc Disease
Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical
Multicenter Post market clinical follow-up Study on the Safety and Performance of Ennovate® Cervical - Prospective, pure data collection of all Ennovate Cervical patients in Total Indications
- Conditions
- Spine Fracture, Degenerative Disc Disease, Spinal Instability, Spinal Tumor
- Trial name
- CERISE (NCT05296889)
- Testing
- posterior stabilization for the cervical spine
- Where
- 4 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Aesculap AG
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis
- Trial name
- NCT05029726
- Testing
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- John O'Toole
Glioma, Medulloblastoma
PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications
Background: About 90,000 new cases of brain and spinal cord tumors are diagnosed annually in the United States. Most of these tumors are benign; however, about 30% are malignant, and 35% of people with malignant tumors in the…
- Conditions
- Glioma, Medulloblastoma, Ependymoma, Glioblastoma
- Trial name
- NCT06161519
- Testing
- PLX038
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- National Cancer Institute (NCI)
Pancreas Cancer, Lung Cancer
Stereotactic Magnetic Resonance Guided Radiation Therapy
This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer.
- Conditions
- Pancreas Cancer, Lung Cancer, Renal Cancer, Adrenal Metastases
- Trial name
- NCT04115254
- Testing
- MR-guided Linac
- Where
- 2 sites in United States
- Volunteers
- 397 people
- Sponsor
- Dana-Farber Cancer Institute