Clinical trials: Splenectomy
Thrombocytopenia, Idiopathic Thrombocytopenic Purpura
AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy
The purpose of this study is to evaluate the efficacy of AMG 531 in the treatment of thrombocytopenia in subjects with ITP as measured by the platelet response.
- Trial name
- NCT00102336
- Testing
- AMG 531
- Volunteers
- 62 people
- Sponsor
- Amgen
Infection;Post Surg Procedure, Peritoneal Cancer
Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)
The spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites.
- Trial name
- OPSI (NCT05718726)
- Testing
- Questionnaire, interview or observation study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Hampshire Hospitals NHS Foundation Trust
Liver Cirrhosis, HCC - Hepatocellular Carcinoma
Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function
Splenectomy may relieve hypersplenism, reverse liver fibrosis, improve hepatic functional reserve, and reshape the systemic antitumor immune milieu by removing the source of negative immunomodulation.
- Conditions
- Liver Cirrhosis, HCC - Hepatocellular Carcinoma, Hypersplenism
- Trial name
- LHCS-HFRI (NCT07811687)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Portal Hypertension, Liver Cirrhosis
Laparoscopic Versus Open Devascularization for Portal Hypertension, a Randomized Controlled Trial
Many patients with portal hypertension require surgical treatment each year,and Hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure.
- Trial name
- NCT02178319
- Testing
- open surgical procedure, laparoscopic surgical procedure
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Pancreatic Cancer, Pancreatectomy
Spleen Preservation Versus Splenectomy in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)
Rationale: During left pancreatectomy for pancreatic ductal adenocarcinoma (PDAC), routine en-bloc splenectomy is performed to achieve complete nodal clearance of the splenic hilum.
- Conditions
- Pancreatic Cancer, Pancreatectomy, Adenocarcinoma Pancreas
- Trial name
- SPLENDID RCT (NCT07799298)
- Testing
- SPLP, LPS
- Where
- Netherlands
- Volunteers
- 360 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adult Patients, Immune Primary Thrombocytopenia
TPO-mimetics Before Splenectomy in Adult Primary Immune Thrombocytopenia Patients.
This study aims at analyzing the therapeutic activity of TPO-mimetics Eltrombopag and Romiplostim as bridge therapy for splenectomy in adult patients with primary immune thrombocytopenia.
- Conditions
- Adult Patients, Immune Primary Thrombocytopenia, Splenectomy, TPO-mimetics
- Trial name
- ITP0614 (NCT02063763)
- Where
- 14 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Idiopathic Thrombocytopenic Purpura
Study of the Safety and Immunogenicity of Long-term GNR-069 Therapy in ITP Patients
It is a phase III extension study to assess safety and immunogenicity of long-term therapy with GNR-069 in patients with idiopathic thrombocytopenic purpura
- Trial name
- NCT05492409
- Testing
- GNR-069
- Where
- 13 sites in Russia
- Volunteers
- 160 people
- Sponsor
- AO GENERIUM
Sickle Cell Anemia, Thalassemia
The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia
The spleen in Sickle Cell Anemia and Sickle Cell Thalassemia is usually enlarged in the first years of life but the immune protection provided is considered insufficient.
- Trial name
- NCT00971698
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Splenic Injury
Treatment of Splenic Trauma: a Retrospective Cohort Study
In blunt trauma, the spleen is most frequent injured organ in the abdomen and the most frequent source of bleeding in the abdomen. Historically, splenectomy was the treatment of choice for splenic bleeding.
- Trial name
- NCT01965548
- Testing
- Treatment of splenic injury
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- University Hospital of North Norway
Immune Thrombocytopenia
An Open-label Safety Study of Lusutrombopag (S-888711) in Adults With Chronic Immune Thrombocytopenia (ITP)
The primary objective of this study was to assess the long-term safety of lusutrombopag in the treatment of adults with relapsed persistent or chronic ITP with or without prior splenectomy.
- Trial name
- NCT01129024
- Testing
- Lusutrombopag
- Where
- 19 sites in United States
- Volunteers
- 19 people
- Sponsor
- Shionogi
Chronic Idiopathic Thrombocytopenic Purpura, Purpura, Thrombocytopenic, Idiopathic
Clinical Evaluation of SB-497115-GR in Chronic Idiopathic Thrombocytopenic Purpura (ITP)
This is a Phase II/III multicenter study comprising of the double-blind, followed by open-label phases to evaluate and compare the efficacy and tolerability of eltrombopag (SB-497115-GR) in chronic ITP patients
- Trial name
- NCT00540423
- Testing
- SB-497115-GR 12.5mg, SB-497115-GR 25mg, SB-497115-GR 50 mg
- Where
- 7 sites in Japan
- Volunteers
- 23 people
- Sponsor
- GlaxoSmithKline
Cirrhosis, Liver, Splenectomy; Status
The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on the Immune Function for Cirrhosis Patients
In this study, the investigators compared the improvement of immune function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection.
- Trial name
- ELSDI (NCT05338294)
- Testing
- Laparoscopic splenectomy and azygoportal disconnection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
Splenectomy; Status
Total Splenectomy vs Partial Splenectomy in Non-malignant Hemoglobinopathies : Study Comparing the Effectiveness
Partial splenectomy or total splenectomy are the two surgical treatment of non-malignant hemoglobinoptahie. The aim of this treatment is to decrease transfusion.
- Trial name
- NCT05184647
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Hereditary Spherocytosis
The Dallas Hereditary Spherocytosis Cohort Study
The purpose of this study is to 1. better characterize the short term and long term natural history of hereditary spherocytosis (HS) including diagnosis, complications, and indications for and response to splenectomy 2.
- Trial name
- NCT01141621
- Volunteers
- 55 people
- Sponsor
- University of Texas Southwestern Medical Center
Cirrhosis, Splenectomy; Status
Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue
- Trial name
- LS-RF (NCT07585773)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital