Clinical trials: Spondylitis
Spondyloarthritis
Etanercept (Enbrel) in Undifferentiated Spondyloarthritis
The study has the aim to investigate the efficacy and safety of etanercept in patients with active undifferentiated spondyloarthritis (uSpA) over the period of 520 weeks.
- Trial name
- Enbrel_uSpA-2 (NCT01289730)
- Testing
- Etanercept
- Where
- 2 sites in Germany
- Volunteers
- 8 people
- Sponsor
- Charite University, Berlin, Germany
Psoriatic Arthritis
Efficacy and Safety of Fecal Microbiota Transplantation in Peripheral Psoriatic Arthritis
An abnormal intestinal microbiota may be the mediator of the common inflammatory pathways seen in psoriatic arthritis. This study will explore clinical aspects associated with modifying the intestinal microbiota by infusing fecal…
- Trial name
- FLORA (NCT03058900)
- Testing
- Fecal microbiota transplantation (FMT), Methotrexate (MTX)
- Where
- 2 sites in Denmark
- Volunteers
- 31 people
- Sponsor
- Odense University Hospital
Psoriatic Arthritis, Atherosclerosis
Vascular Effects of Achieving Minimal Disease Activity in Psoriatic Arthritis - a 2 Year Prospective Cohort Study
Objectives To investigate the effect of achieving minimal disease activity (MDA) using a protocolized treatment strategy on the progression of subclinical atherosclerosis and arterial stiffness in psoriatic arthritis (PsA)…
- Conditions
- Psoriatic Arthritis, Atherosclerosis, Arterial Stiffness
- Trial name
- NCT02232321
- Testing
- PsA MDA
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Chinese University of Hong Kong
Inflammatory Arthritis, Ankylosing Spondylitis
Impact of Barriers and Facilitators to Physical Activity in Patients With Inflammatory Arthritis
Background: Patients with inflammatory arthritis (IA), such as spondyloarthritis (axSpA), rheumatoid arthritis (RA) or psoriatic arthritis (PsA) are more prone to physical inactivity but derive specific benefits from regular…
- Conditions
- Inflammatory Arthritis, Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis
- Trial name
- ImBAIA (NCT04426747)
- Testing
- No intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
DLQI, PHQ-9
To Evaluate the Mechanism of Jing Si Herbal Tea Liquid Packets and Traditional Western Medicine for Psoriasis
Psoriasis is a chronic cutaneous inflammatory disease due to immune dysregulation. It caused skin lesions with thickening plaques and heavy silver scales over the patient's body surface area, including nail deformity, often…
- Conditions
- DLQI, PHQ-9, PSAI, Serum Cytokine Survey
- Trial name
- NCT05436938
- Testing
- Jing Si herbal tea liquid packets use
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Psoriatic Arthritis
Validation of the PsASon ULtrasound Scores in Patients With Psoriatic Arthritis Undergoing TReatment With Apremilast
The main purpose of this study is to validate the ultrasound scores PsASon22 and PsASon13 in patients with active psoriatic arthritis undergoing a treatment with Apremilast.
- Trial name
- PSA-ULTRA (NCT04102449)
- Testing
- Apremilast
- Where
- Austria
- Sponsor
- Medical University of Graz
Psoriasis, Arthritis, Psoriatic
Anti-Carbamylated Protein Antibodies in Psoriatic Arthritis
Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic…
- Trial name
- CARPAPA (NCT04173039)
- Testing
- Serum anti-CarP antibodies detection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Association pour la Recherche Clinique et Immunologique
Rheumatic Disease, Rheumatic Disorder
Survey About Diet in Chronic Inflammatory Rheumatic Diseases
A French Survey on patients' practices, knowledge and beliefs about diet in chronic inflammatory rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, spondylarthritis) Use of a questionnaire about what patients have…
- Conditions
- Rheumatic Disease, Rheumatic Disorder, Inflammatory Rheumatism, Rheumatoid Arthritis
- Trial name
- NCT05283096
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Poitiers University Hospital
Spondylitis, Ankylosing
Prediction of the Answer to the Treatment by Biotherapies for Naive Spondyloarthritis by Combinatorial Analysis of Serum Biomarkers
The aim of this trial is the caracterisation of a predicting algorithm of the answering response for patients with etanercept treatment in spondyloarthritis disease.
- Trial name
- PRESA (NCT03033095)
- Testing
- Etanercept ® 50 mg
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Spondylitis, Ankylosing
16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Ankylosing Spondylitis
The purpose of this study is to provide 16-week efficacy, safety and tolerability data versus placebo to support the use of secukinumab 150 mg by subcutaneous (s.c.) self-administration with or without a loading regimen and…
- Trial name
- MEASURE4 (NCT02159053)
- Testing
- Secukinumab
- Where
- 90 sites in United States, Australia and 17 more
- Volunteers
- 350 people
- Sponsor
- Novartis Pharmaceuticals
Non-radiographic Spondyloarthritis
Study of Efficacy and Safety of Secukinumab in Patients With Non-radiographic Axial Spondyloarthritis
The purpose of this study was to demonstrate the clinical efficacy, safety and tolerability of secukinumab compared to placebo in patients with nr-axSpA at Week 16 as well as Week 52 and long term efficacy and safety up to Week…
- Trial name
- PREVENT (NCT02696031)
- Testing
- Secukinumab
- Where
- 139 sites in United States, Australia and 22 more
- Volunteers
- 555 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis, Psoriasis
Psoriatic Arthritis and Psoriasis Treatment Decision Aid
The purpose of this study is to create and test a patient decision aid that facilitates the shared decision-making process when patients with psoriasis and/or psoriatic arthritis are starting or switching to a new therapy.
- Trial name
- DA (NCT03737045)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Ankylosing Spondylitis
A Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis
This is a phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of AK111 in subjects with active ankylosing spondylitis.
- Trial name
- NCT05467995
- Testing
- AK111
- Where
- 15 sites in China
- Volunteers
- 125 people
- Sponsor
- Akeso
Psoriatic Arthritis (PsA)
Psoriatic Arthritis Treat to Target vs. Usual Care
Canadian Rheumatologists will be randomized to treat their participants with active Psoriatic Arthritis to a target (disease activity score <2.6), or as per their routine care.
- Trial name
- PRC-05-2011 (NCT01692912)
- Testing
- Intensive Care
- Where
- 4 sites in Canada
- Sponsor
- Pope Research Corporation
Psoriatic Arthritis, Psoriasis
HIPPOCRATES Prospective Observational Study
HIPPOCRATES is an Innovative Medicines Initiative (IMI) funded EU Consortium established to address key unmet clinical needs in psoriatic disease.
- Trial name
- HPOS (NCT05858528)
- Testing
- PEST screening questionnaire
- Where
- United Kingdom
- Volunteers
- 25,000 people
- Sponsor
- University of Oxford
Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS)
An Investigation of the Effect of Smartphone Usage Levels on Cervical Posture, Tongue Pressure, Balance, and Neck Disability in Individuals With Rheumatoid Arthritis and Ankylosing Spondylitis
The purpose of this cross-sectional and comparative study is to investigate the impact of smartphone addiction on the cervical posture, musculoskeletal system, balance, and tongue pressure in individuals diagnosed with Rheumatoid…
- Conditions
- Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS), Forward Head Posture
- Trial name
- NCT07627542
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Merve Şahin
Fever of Unknown Origin, IgG4 Related Disease
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current…
- Conditions
- Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
- Trial name
- NCT07535554
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Psoriatic Arthritis, Obesity
Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight
The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide…
- Trial name
- TOGETHER-PsA (NCT06588296)
- Testing
- Ixekizumab, Tirzepatide
- Where
- 86 sites in United States, Puerto Rico
- Volunteers
- 279 people
- Sponsor
- Eli Lilly and Company
Ankylosing Spondylitis
A Clinical Study of JS005 in Patients With Ankylosing Spondylitis
This is a multicentre, randomized, double-blind, parallel, placebo-controlled Phase II clinical study of 261 adults with active ankylosing spondylitis to evaluate the efficacy and safety of JS005 in the treatment of active…
- Trial name
- NCT06250062
- Testing
- Recombinant humanized IL-17A Monoclonal Antibody（JS005）
- Where
- 38 sites in China
- Volunteers
- 265 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Spondyloarthritis, Axial Spondyloarthritis
Characterizing Spondyloarthritis With 68Ga-FAPI PET/CT
To evaluate the potential usefulness of 68Ga-FAPI PET/CT for the diagnosis, inflammation evaluation and prognosis prediction in spondyloarthritis.
- Conditions
- Spondyloarthritis, Axial Spondyloarthritis, Ankylosing Spondylitis
- Trial name
- NCT05999643
- Testing
- Drug: 68Ga-FAPI
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Xiamen University