Clinical trials: Spondyloarthritis, Axial, open to volunteers
Axial Spondyloarthritis, Axial Spondyloarthritis, Non-Radiographic
Effectiveness and Safety of Acemetacin in Active Axial Spondyloarthritis: A Real-world Study
The goal of this observational study is to evaluate the effectiveness and safety of acemetacin in adults (18-65 years) with active axial spondyloarthritis (axSpA) who meet the 2025 ASAS-SPARTAN revised classification criteria and…
- Conditions
- Axial Spondyloarthritis, Axial Spondyloarthritis, Non-Radiographic, Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)
- Trial name
- ARISE (NCT07582146)
- Testing
- Acemetacin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Axial Spondyloarthritis, Ankylosing Spondylitis
Fecal Microbiota Transplantation in Axial Spondyloarthritis
Although biologic therapy have revolutionized the treatment of Spondyloarthrtitis (SpA), many patients do not experience complete relief of SpA related complaints.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Dysbiosis, Spondyloarthritis
- Trial name
- MicroSpA (NCT06451588)
- Testing
- FMT
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- University Hospital of North Norway
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
REDO-JAK: Dose Reduction of Janus Kinase Inhibitors in Patients With Inflammatory Rheumatic Diseases
The goal of this clinical trial is to assess the effectiveness of a disease activity guided dose reduction strategy of Janus kinase inhibitor (JAKi) compared to disease activity guided JAKi continuation in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondyloarthritis (AxSpA)
- Trial name
- REDO-JAK (NCT07160231)
- Testing
- JAKi dose reduction strategy, JAKi disease activity guided continuation of same dose strategy
- Where
- 7 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Sint Maartenskliniek
Axial Spondyloarthritis and Ankylosing Spondylitis
Effects of Land- and Water-Based Exercise in Axial Spondyloarthritis
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by pain, morning stiffness, restricted spinal mobility, and systemic manifestations.
- Trial name
- NCT07833033
- Testing
- Land-Based Combined Exercise Program, Aquatic Combined Exercise Program, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
Ankylosing Spondylitis, Low Back Pain
Impact of Low Back Pain Phenotypes on Function and Quality of Life in Ankylosing Spondylitis
This study aims to better understand different types of low back pain in patients with ankylosing spondylitis. Low back pain is a common problem in these patients and may affect daily activities and quality of life.
- Trial name
- Backpaın (NCT07510789)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Axial Spondyloarthritis, Ankylosing Spondylitis
Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy
The goal of this clinical trial is to find out if the study drug will work as a new therapy for axSpA patients. This study is placebo-controlled, and evaluates if study drug can treat symptoms of axSpA, including global disease…
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, r-axSpA, Nr-axSpA
- Trial name
- V-SPINE (NCT06526377)
- Testing
- vilamakitug
- Volunteers
- 150 people
- Sponsor
- XBiotech, Inc.
Anklyosing Spondylitis, Telerehabilitation
Effectiveness of Telerehabilitation in Ankylosing Spondylitis
Purpose of the study: Ankylosing spondylitis (AS) is a chronic disease that affects the spine and joints, causing pain, stiffness, fatigue, and reduced quality of life.
- Trial name
- NCT07503327
- Testing
- Synchronous Telerehabilitation Exercise Program, Asynchronous Telerehabilitation Exercise Program, Brochure Program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Inonu University
Ankylosing Spondylitis (AS)
Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis
Background: Ankylosing spondylitis (AS) is a chronic, progressive inflammatory disease mainly affecting the spine and sacroiliac joints, causing pain, stiffness, structural damage, and functional disability.
- Trial name
- NCT07894497
- Testing
- Ivarmacitinib with celecoxib, Ivarmacitinib Monotherapy
- Volunteers
- 138 people
- Sponsor
- Peking University Third Hospital
Spondyloarthritis, Axial, Fatigue
Fatigue and Skeletal Muscle Impact in Severe Axial Spondyloarthritis
Axial spondyloarthropathy (SpA) is the most common inflammatory rheumatism (1% of the general population) with important medico-economic consequences. Fatigue is a major feature of SA.
- Conditions
- Spondyloarthritis, Axial, Fatigue, Exercise Capacity
- Trial name
- Famuspa (NCT03940911)
- Testing
- Measurement of aerobic exercise on cycloergometer
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Strasbourg, France
Axial Spondyloarthritis (axSPA)
Effects of Yoga Therapy in Rehabilitation Compared to Physiotherapy in Moderate Axial Spondyloarthritis (axSPA)
A few studies have evaluated the effectiveness of yoga therapy in patients with axial spondyloarthritis (axSPA). On the other hand, studies conducted in other chronic rheumatisms such as low back pain, rheumatoid arthritis or…
- Trial name
- YOKISPA (NCT06083090)
- Testing
- Yogatherapy, Physiotherapy
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spondylarthritis
IL17 Rate and Spondyloarthritis
There are, to date, no validated biomarkers or head-to-head RCTs of biologics to guide choice of biologic agent in axSpA. While there are now two head-to-head studies of a TNF inhibitor (TNFi) vs an IL-17 inhibitor (IL-17i) in…
- Trial name
- NCT05592574
- Testing
- Blood sample
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Spondylarthritis, Inflammatory Bowel Diseases
Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease
The QUESAM study aims to translate into French and validate the traduction of 2 screening questionnaires for spondylo-arthritis among people with inflammatory bowel disease.
- Conditions
- Spondylarthritis, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- QUESAM (NCT06998316)
- Testing
- Screening questionnaire
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Grenoble
Axial Spondyloarthritis
Physical Activity Through Health Technology in Axial Spondyloarthritis
The purpose of this study is to find out whether a mobile app called the ExerciseRx app is a practical and helpful way for people with axial spondyloarthritis (axSpA) to receive exercise recommendations as part of their regular…
- Trial name
- NCT07642622
- Testing
- Physical activity program intervention, Usual Care Group
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA)
A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases.
Ankylosing spondylitis, radiographically negative axial spondyloarthritis, psoriatic arthritis, polymyalgia rheumatica, Takayasu arteritis, giant cell arteritis, non-ocular Behcet's disease, and enthesitis-related arthritis are…
- Conditions
- Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Nr-axSpA, Polymyalgia Rheumatica (PMR)
- Trial name
- V-MIRACLE (NCT06766552)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Active Non-radiographic Axial Spondyloarthritis
A Trial of SHR-1314 Injection in Adult Patients With Active Non-radiographic Axial Spondyloarthritis
The study is being conducted to evaluate the efficacy and safety of SHR-1314 injection in adult patients with active non-radiographic axial spondyloarthritis.
- Trial name
- NCT06860750
- Testing
- SHR-1314 Injection
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Ankylosing Spondylitis
The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development…
- Trial name
- NCT07166874
- Testing
- Gluten Free Diet
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Inflammatory Arthritis
Effect of a Self-Management Intervention for Patients Newly Diagnosed With Inflammatory Arthritis: The NISMA Trial
Background: In patients newly diagnosed with inflammatory arthritis, a self-management intervention is anticipated to enhance self-management skills, thereby improving patient function, well-being, and survival.
- Trial name
- NCT06533423
- Testing
- Newly diagnosed with Inflammatory arthritis - a Self-MAnagement intervention (NISMA)
- Where
- 2 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Axial Spondyloarthritis, Ankylosing Spondylitis
A Study to Assess the Safety of Subcutaneous Secukinumab for Treatment in Adult Indian Participants With Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS), and Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
The aim of this study is to assess the safety of secukinumab in Indian adult participants with axSpA, AS, and nr-axSpA over a 16-week treatment period.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Non-Radiographic Axial Spondyloarthritis
- Trial name
- NCT07737730
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis, Ankylosing Spondylitis
Korean College of Rheumatology Biologics and Targeted Therapy Registry
We established a nationwide biologics and targeted synthetic DMARDs registry (in the form of an inception cohort) to study the safety profiles in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis patients…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- KOBIO (NCT01965132)
- Testing
- Biologic or targeted synthetic DMARD
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Seoul National University Hospital