Clinical trials: Spontaneous Abortion
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Pregnancy, Pregestational Diabetes
Safety of Metformin in Pregnancy
This study aims to better characterize the risk linked to metformin use during pregnancy, using a prospective multicentric cohort design enabling a large sample size, in evaluating the rate of birth defects after first trimester…
- Conditions
- Pregnancy, Pregestational Diabetes, Polycystic Ovary Syndrom
- Trial name
- NCT02793505
- Testing
- metformin, any drug not known as a major teratogen or major fetotoxicant
- Volunteers
- 950 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pregnancy Related, Pregnancy Complications
The Heartland Study
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..
- Conditions
- Pregnancy Related, Pregnancy Complications, Birth Defect, Gestational Age and Weight Conditions
- Trial name
- NCT05492708
- Where
- 4 sites in United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Heartland Health Research Alliance
Major Depressive Disorder, Miscarriage
Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss
The purpose of this study is to conduct a randomized pilot trial in a sample of 60 women who meet criteria for Major Depressive Disorder (MDD) 1-18 months after a perinatal loss to demonstrate the feasibility of the proposed…
- Conditions
- Major Depressive Disorder, Miscarriage, Stillbirth, Neonatal Death
- Trial name
- NCT01867749
- Testing
- Group Interpersonal Psychotherapy (IPT-G), Coping with Depression (CWD)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Brown University
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Pregnancy
Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage
The aim of this study is to determine whether the dydrogesterone therapy is associated with reduction in miscarriage in women with first trimester threatened miscarriage.
- Trial name
- NCT02128685
- Testing
- Dydrogesterone
- Where
- 3 sites in Hong Kong
- Volunteers
- 406 people
- Sponsor
- The University of Hong Kong
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Miscarriage
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified.
- Trial name
- NCT04492098
- Testing
- MAIT cells
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Birth Defects, Miscarriages
Pesticides--Health Fertility and Reproductive Risk
This project is designed to establish whether pesticides or other environmental agents have a role in the excess birth defects identified in the Red River Valley of Minnesota.
- Conditions
- Birth Defects, Miscarriages, Cancer
- Trial name
- NCT00015561
- Where
- United States
- Volunteers
- 1,803 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Miscarriage
Sublingual Versus Vaginal Misoprostol In Medical Treatment of Second Trimestric Missed Miscarriage
The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of the second trimester missed miscarriage
- Trial name
- NCT05088707
- Testing
- sublingual misoprostol, vaginal misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Early Pregnancy Loss, Abortion, Spontaneous
Surgical vs. Medical Abortion on Sexual Function After Early Pregnancy Loss
This study compares the medium-term effects of surgical and medical abortion on sexual function in women who have experienced early pregnancy loss (6-12 weeks gestation).
- Conditions
- Early Pregnancy Loss, Abortion, Spontaneous, Miscarriage, Pregnancy, Unwanted
- Trial name
- SF-EPL (NCT07646275)
- Testing
- mifepristone and misoprostol, Vacuum Aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Harran University
Miscarriage, Grief
Couples Miscarriage Healing Project:Randomized Trial
This is a randomized trial of three caring based interventions to see if we can help couples heal after miscarriage. All three are based on Swanson's theory of caring and Meaning of Miscarriage Model.
- Conditions
- Miscarriage, Grief, Pregnancy Loss
- Trial name
- NCT00194844
- Testing
- Nurse Caring, Self Caring, Combined Caring
- Where
- United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pregnancy, Infertility
Selenium Supplementation in Pregnancy
Serum levels of isolated anti-thyroperoxidase (TPOab) and anti-thyreoglobulin (Tgab) autoantibodies are strongly associated with an increased risk of miscarriage and premature deliveries in euthyroid pregnant women.
- Conditions
- Pregnancy, Infertility, Auto-immune Thyroiditis
- Trial name
- Serena (NCT01465867)
- Testing
- Selenium, Selenium + L-Thyroxine (LT4)
- Where
- 11 sites in Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Abortion, Missed
Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage
This study compares the success rate of Adjuvant isonicotinic acid hydrazide and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04499976
- Testing
- Isonicotinic Acid, Misoprostol
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Aswan University Hospital
Miscarriage Threatening
Comparison of Dydrogesterone and Micronized Progesterone Treatments in the Treatment of Threatened Miscarriage.
In this study, we aimed to compare the effects of two drugs used for the threated miscarriage on the miscarriage rate.
- Trial name
- NCT05542797
- Testing
- Duphastone
- Volunteers
- 140 people
- Sponsor
- Konya Meram State Hospital
Septic Abortion
Clindamycin Once a Day in Septic Abortion
Septic abortion is a serious condition. Women with septic abortion are treated with clindamycin plus gentamicin using divided doses, i.e., thrice a day.
- Trial name
- CLINDA-PRO (NCT02309346)
- Testing
- Clindamycin
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Stillbirth and Fetal Death, Miscarriages
Parents' Experience of Child Loss During Pregnancy or Birth
The investigators are conducting a participatory study with and for parents after child loss during pregnancy or birth. Their aim is to develop treatment recommendations for healthcare professional.
- Conditions
- Stillbirth and Fetal Death, Miscarriages, Experience
- Trial name
- NCT06771661
- Testing
- Workshops, Focus group interviews, Narrative interviews
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Fritz Sterr
Infertility, Recurrent Pregnancy Loss
Preimplantation Genetic Diagnosis Using Blastocyst Biopsy and Array CGH
The investigators propose to perform a clinical randomized trial to evaluate the effect of single embryo (blastocyst) transfer (SET) with array CGH for the evaluation of the complete chromosome complement of the blastocyst in…
- Trial name
- NCT01546350
- Testing
- PGD
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Reprogenetics
Perinatal Death, Hypertension, Pregnancy-Induced
Pregnancy in the Context of Urbanicity and Climate Change. The Overall Aim of the Project is to Co-create, Implement, and Test New Clinical Guidelines in Order to Improve the Quality of Care in Antenatal Clinics in the Context of Urbanisation and Climate Change in Dar es Salaam, Tanzania.
Tanzania's population is growing quickly, and Dar es Salaam is one of the fastest-growing cities in the world. At the same time, the city is increasingly affected by very hot weather, flooding, and air pollution.
- Conditions
- Perinatal Death, Hypertension, Pregnancy-Induced, Abortion, Spontaneous, Stillbirth
- Trial name
- NCT07751432
- Testing
- CC-ANC intervention group.
- Where
- Tanzania
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine