Clinical trials: Spontaneous Breathing Trial
Relationship Between Dyspnea and Ventilatory Variability
Respiratory Variability and Dyspnea During Spontaneous Breathing Trial
In intensive care unit, dyspnea, the distressing and fearful awareness of breathing, is frequent and harmful. To be treated, dyspnea must be detected and quantified, which is impossible in approximately 50% of patients receiving…
- Trial name
- DYSREVA (NCT05762614)
- Testing
- Dyspnea assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Premature
dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure.
- Trial name
- NCT05865977
- Testing
- diaphragmatic tissue Doppler imaging，dTDI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wang Jianhui
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Extubation Failure
Performance of the Variation in Arterial Lactatemia During a Spontaneous Breathing Trial (SBT) in the Prediction of Extubation Failure
Extubation failure (EF) is independently associated with excess mortality of critically ill patients. To avoid EF, critically ill patients being weaned from invasive mechanical ventilation (IMV) perform spontaneous breathing…
- Trial name
- PREDILACT (NCT05487573)
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Weaning Failure, Weaning-induced Pulmonary Edema
Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational Study
During weaning from mechanical ventilation, the shift from positive to negative pressure ventilation may be responsible for a cardiac dysfunction that can lead to the development of pulmonary oedema (weaning-induced pulmonary…
- Conditions
- Weaning Failure, Weaning-induced Pulmonary Edema, Spontaneous Breathing Trial
- Trial name
- WIPO (NCT05318261)
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
Atelectasis, Postoperative Pulmonary, Bariatric Surgery
Postoperative Hypoxemia in Obese Patients
Postoperative atelectasis can cause postoperative hypoxia which might be avoided by applying pressure support during extubation of obese patients undergoing bariatric surgeries.
- Trial name
- RCT (NCT06589011)
- Testing
- Pressure Support Ventilation, spontaneously assisted breathing
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Theodor Bilharz Research Institute
Critically Ill Adult Patients With Difficult Weaning
Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial
The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can…
- Trial name
- SBT-ICU (NCT03861117)
- Testing
- Assisted strategy, Non assisted strategy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Hospices Civils de Lyon
Intensive Care Unit, Invasive Mechanical Ventilation
Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation
Assessment and comparison of three spontaneous breathing trials in five specific profiles of intensive care unit and perioperative patients. A physiological cross over study
- Conditions
- Intensive Care Unit, Invasive Mechanical Ventilation, Ready to Wean From Ventilation
- Trial name
- GLOBAL WEAN (NCT04222569)
- Testing
- T-piece, PSV 7 and PEEP 0, PSV 0 and PEEP 0
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease
Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of the study is to evaluate the efficacy of Helium/Oxygen (He/O2) 78%/22% compared to a conventional Air/O2 mixture in reducing endotracheal intubation rate and mortality in patients with severe hypercapnic…
- Trial name
- ECHO/ICU (NCT01155310)
- Testing
- Helium/Oxygen 78%/22%, Air/Oxygen
- Where
- 16 sites in Belgium, France and 4 more
- Volunteers
- 446 people
- Sponsor
- Air Liquide Santé International
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Weaning of Mechanical Ventilation, Chronic Obstructive Pulmonary Disease
Spontaneous Breathing Trials Using Pressure-Support or T-Tube in Chronic Obstructive Pulmonary Disease Patients Weaning Mechanical Ventilation
Weaning of mechanical ventilation (MV) is an essential part in management of patients with Chronic Obstructive Pulmonary Disease (COPD) when critically ill. The best strategy to be used has not been established.
- Trial name
- NCT01464567
- Testing
- "T" Tube Spontaneous Breathing Trial, Pressure Support Ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 190 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Stability During Surgical Operation, Complication, Postoperative
Clinical Trial of Thoracoscopic Bullectomy Surgery Under Spontaneous Ventilating Anesthesia
With the development of video-assisted thoracoscopic surgery (VATS) techniques and technology for anesthesia control, non-intubated anesthesia with spontaneous ventilation has been widely applied in VATS.
- Conditions
- Stability During Surgical Operation, Complication, Postoperative, Postoperative Hospitalization Time
- Trial name
- NCT03016858
- Testing
- Thoracoscopic Bullectomy Surgery
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Weaning From Mechanical Ventilation, Extubation
Direct Extubation Versus Extubation After a Spontaneous Breathing Trial in Patients at Low Risk of Extubation Failure
This randomized controlled open label trial aims at comparing a weaning strategy including a spontaneous breathing trial as a prerequisite for extubation to a weaning strategy without a spontaneous breathing trial (direct…
- Trial name
- T-REX (NCT07019636)
- Testing
- Weaning strategy with direct extubation (no spontaneous breathing trial), Weaning strategy with extubation only after a successful spontaneous breathing
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dyspnea Invasive Mechanical Ventilation-associated
Dyspnea Facial Recognition During Weaning
Critically ill patients are exposed to many sources of discomfort and traumatic experiences, especially if they require invasive mechanical ventilation (IMV).
- Trial name
- DYS-FEREA (NCT05163275)
- Testing
- Video recording and EMG
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation, Weaning
Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients
This study will compare Drager Smart Care (SC), a commercially available automated ventilator controlled weaning mode to the current daily spontaneous breathing trial (SBT) weaning protocol.
- Trial name
- NCT00813839
- Testing
- daily weaning trails
- Where
- United States
- Sponsor
- University of California, San Francisco
Endoscopic Laryngeal Surgery
Dex vs SLNB in Spontaneous Breathing Via THRIVE for Laryngeal Surgery
This prospective, randomized controlled trial evaluated the efficacy and safety of two anesthetic strategies-dexmedetomidine infusion and ultrasound-guided superior laryngeal nerve block (SLNB)-in patients undergoing…
- Trial name
- NCT05581485
- Testing
- Dexmetedomedine infusion, Ultrasound-Guided Superior Laryngeal Nerve Block (SLNB)
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Kaohsiung Veterans General Hospital.