Clinical trials: Stable Angina
Stable Angina
COBRA SHIELD OCT Study
Phase one of this study is a prospective, randomized (2:1), pilot study that will evaluate COBRA PzF vascular healing patterns and thrombus formation with Optical Coherence Tomography (OCT) at 3 months after stent implantation in…
- Trial name
- NCT02224235
- Testing
- Aspirin, Resolute Integrity DES, COBRA PzF
- Where
- 2 sites in Finland
- Volunteers
- 8 people
- Sponsor
- CeloNova BioSciences, Inc.
Stable Angina, Non-ST-elevation Acute Coronary Syndrome
Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry)
JDEPTH-LM Registry is a prospective, observational, multi-center study designed for the efficacy and safety of Double-effect kissing balloon technique (W-KBT) in left main (LM) bifurcation percutaneous coronary intervention (PCI)…
- Conditions
- Stable Angina, Non-ST-elevation Acute Coronary Syndrome, Unstable Angina
- Trial name
- NCT06436092
- Where
- 32 sites in Japan
- Volunteers
- 280 people
- Sponsor
- TCROSS Co., Ltd.
Angina Pectoris
Angiogenesis in Women With Angina Pectoris Who Are Not Candidates for Revascularization
The purpose of this study is to determine whether a one-time intracoronary infusion of Ad5FGF-4 is effective in reducing the time to onset myocardial ischemia as measured by exercise treadmill testing and improving myocardial…
- Trial name
- AWARE (NCT00438867)
- Testing
- Ad5FGF-4
- Where
- 47 sites in United States
- Volunteers
- 300 people
- Sponsor
- Cardium Therapeutics
Stable Angina, Coronary Artery Disease
CCTA, CACS and ECG Stress Testing in Patients With Suspected CAD: Precision Phenotyping and Financial Evaluation
The "DATASET-PRECISE", a 3-arm parallel randomized study, aims to provide new insights in risk stratification of patients with suspected CAD in the Greek population.
- Conditions
- Stable Angina, Coronary Artery Disease, Atherosclerosis, Coronary Artery Calcification
- Trial name
- DATASET (NCT04424121)
- Testing
- CCTA
- Where
- 3 sites in Greece
- Volunteers
- 900 people
- Sponsor
- Aristotle University Of Thessaloniki
Microvascular Angina, Angina Pectoris
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected.
- Conditions
- Microvascular Angina, Angina Pectoris, Angina, Stable, Non-Obstructive Coronary Atherosclerosis
- Trial name
- CorCMR (NCT04805814)
- Testing
- CMR results disclosed, CMR performed but results not disclosed
- Where
- 3 sites in United Kingdom
- Volunteers
- 280 people
- Sponsor
- NHS National Waiting Times Centre Board
Stable Coronary Artery Disease (CAD), Unstable Angina (Troponin Negative)
Safety of Argatroban Infusion in Conduction Disturbances
To determine change of QTc interval during intravenous argatroban infusion in patients undergoing percutaneous coronary intervention (PCI)
- Trial name
- SAICoDis (NCT05740371)
- Testing
- Argatroban
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Tanabe Pharma GmbH
Chronic Stable Angina
Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina.
This study is to determine the anti-anginal and anti-ischemic effect of k-channel opener, nicorandil in patients of chronic stable angina.
- Trial name
- NCT01397994
- Testing
- Nicorandil, Atenolol
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ferozsons Laboratories Ltd.
Stable Angina, Unstable Angina
International Randomized Comparison Between DES Limus Carbostent and Taxus DES in the Treatment of De-novo Coronary Lesions
The purpose of this study is to demonstrate non-inferiority in terms of safety and efficacy of DES Limus Carbostent compared to the Taxus Liberté in treating de-novo atherosclerotic lesions in native coronary arteries.
- Conditions
- Stable Angina, Unstable Angina, Documented Silent Ischemia
- Trial name
- NEXT (NCT01373502)
- Testing
- DES Limus Carbostent, Taxus Liberté Stent
- Where
- 11 sites in Belgium, France and 2 more
- Volunteers
- 323 people
- Sponsor
- CID - Carbostent & Implantable Devices
Class IV Angina
CardioGenesis Transmyocardial Revascularization 1-Year Follow-Up Study
The purpose of this study it to collect real world 30-day and 1-year follow-up data for patients undergoing TMR with the CardioGenesis Holmium:YAG Laser System either as a sole therapy procedure or in conjunction with coronary…
- Trial name
- NCT02694861
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- CryoLife, Inc.
Angina Pectoris
Efficacy and Safety of Lacidipine in Chronic Stable Angina
The aim of this study was to explore whether lacidipine at doses of 2 mg, 4 mg and 6 mg decreased the symptoms of angina, compared to placebo in patients with chronic stable angina
- Trial name
- NCT02232607
- Testing
- Lacidipine, low dose, Lacidipine, medium dose, Lacidipine, high dose
- Volunteers
- 283 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Stent Thrombosis
Platelet Reactivity in Stent Thrombosis Patients
Recent studies have demonstrated a marked interindividual variability of clopidogrel's capacity to inhibit platelet aggregation with a substantial proportion (11-34%) of the patients considered non-responders to clopidogrel…
- Trial name
- MAPCAT (NCT01012544)
- Testing
- Clopidogrel
- Where
- Netherlands
- Volunteers
- 187 people
- Sponsor
- St. Antonius Hospital
Stable Angina
A Placebo-controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina
ORBITA-2 is a double blinded randomised placebo-controlled trial comparing the effects of coronary angioplasty versus placebo procedure on symptoms of stable angina without background anti-anginal therapy.
- Trial name
- ORBITA-2 (NCT03742050)
- Testing
- Percutaneous coronary intervention
- Where
- 8 sites in United Kingdom
- Volunteers
- 439 people
- Sponsor
- Imperial College London
Coronary Artery Disease, Endothelial NO-synthase
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease
The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the importance of the NO-stimulated…
- Trial name
- NCT02265016
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Stable Angina
Comparative Effectiveness of Decision Aids for Stable Chest Discomfort
The purpose of the study is to compare two different types of decision support materials for patients considering treatment for chest pain or chest discomfort from heart disease.
- Trial name
- NCT02652208
- Testing
- Online decision aid, Video decision aid
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Angina, Stable Ischemic Heart Disease
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple…
- Trial name
- LIVEBETTER (NCT05786417)
- Testing
- Clinician Discretion, Beta blocker, Calcium channel blocker
- Where
- 10 sites in United States
- Volunteers
- 741 people
- Sponsor
- Yale University
Coronary Artery Disease
The Influence of Febuxostat on Coronary Artery Endothelial Dysfunction in Participants With Chronic Stable Angina
The purpose of this study is to assess the effect of febuxostat on coronary artery flow in patients with coronary artery disease.
- Trial name
- NCT01763996
- Testing
- Febuxostat
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Takeda
Coronary Artery Disease, Stable Angina
Randomized Controlled Study of the Traditional Percutaneous Coronary Intervention and Intervention Using Optical Coherence Tomography of Incomplete Stent Adhesion and Extent of the Formation of Neointima by Resolute Zotarolimus-eluting Stent Insertion
Optical coherence tomography (OCT) after the stent procedure to improve the adhesion and expansion, or incomplete uncovered struts attached to the main track.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- NCT01869842
- Testing
- percutaneous coronary intervention, OCT-guided percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Yonsei University
Stable Angina, Coronary Disease
Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina
This study of 402 cases of stable angina subjects who were diagnosed as Coronary Heart Disease (CHD) is a randomized, blank controlled, multi-center clinical study.
- Trial name
- SIGMART (NCT01396395)
- Testing
- Nicorandil, Standard Treatment
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center