Clinical trials: Stable Coronary Artery Disease
Postmenopausal Women, Stable Angina Pectoris
Coronary Artery Disease (CAD) in Postmenopausal Women
Aim of this study is the determination of a valid procedure for ischemia diagnositc in postmenopausal women.
- Trial name
- FEMCAD (NCT00763464)
- Testing
- stress-echocardiography, stress-MRI
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Coronary Disease, Ventricular Dysfunction, Left
The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction
The aim of this study is to test whether ivabradine is able to reduce cardiovascular events when given to patients with coronary artery disease and impaired heart function.
- Trial name
- NCT00143507
- Testing
- Ivabradine
- Where
- United Kingdom
- Volunteers
- 10,917 people
- Sponsor
- Institut de Recherches Internationales Servier
Coronary Artery Disease
A Study of the Onset and Offset of Antiplatelet Effects Comparing Ticagrelor, Clopidogrel, and Placebo With Aspirin
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet medication, affects platelets. Anti-platelet agents are medications that block the formation of blood clots by preventing the clumping of…
- Trial name
- NCT00528411
- Testing
- Ticagrelor Tablets, Clopidogrel (over encapsulated) capsule, Aspirin Tablets
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 123 people
- Sponsor
- AstraZeneca
Stable Coronary Artery Disease (CAD), Myocardial Infarction
Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients
THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and…
- Trial name
- TIGRIS (NCT01866904)
- Where
- 309 sites in United States, Argentina and 23 more
- Volunteers
- 9,284 people
- Sponsor
- AstraZeneca
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Chronic Stable Angina, Coronary Artery Disease
Safety of Amiodarone and Ranolazine Together in Patients With Angina
Ranolazine is an effective and remarkably safe agent for the treatment of patients with chronic stable angina, but its inhibition of voltage gated potassium channels and electrocardiogram (EKG) corrected QT (QTc) prolongation…
- Conditions
- Chronic Stable Angina, Coronary Artery Disease, Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- SARA (NCT01558830)
- Testing
- ranolazine
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cardiovascular Consultants of Nevada
Coronary Artery Disease
Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Olive extracts are considered to have antioxidant properties. The investigators will study the effect of olive extracts containing hydroxytyrosol (HT)-olivomed and combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal…
- Trial name
- NCT04520126
- Testing
- Olivomed (capsules containing hydroxytyrosol), OlivomedSmart - Capsules containing - combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal (OC) - (OL:HT:OC 2:1:3), (5 mg HT bid).
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Athens
Coronary Heart Disease, Angina Pectoris
The Effects of Diesel Exhaust Inhalation On Exercise Capacity In Patients With Stable Angina Pectoris
The purpose of this study is to determine whether exposure to diesel exhaust (air pollution) has a functional impact on patients with stable angina pectoris.
- Trial name
- NCT00737958
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Coronary Artery Disease, Drug Interaction Potentiation
Ranitidin Versus Omeprazole in Patients Taking Clopidogrel
Previous reports have shown a possible drug interaction between clopidogrel and proton pump inhibitors (PPI´s), which could result in increased number of adverse cardiovascular events among patients on dual antiplatelet…
- Trial name
- NCT01896557
- Testing
- omeprazole, Ranitidine, Clopidogrel
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease (CAD)
PLASMA Trial: A Dose-Response Study of A-002 In Subjects With Stable Coronary Artery Disease
The study will be conducted at up to 80 centers worldwide and will be a double-blind randomized parallel group placebo controlled study among subjects with stable coronary artery disease (CAD).
- Trial name
- PLASMA (NCT00455546)
- Testing
- A-002
- Where
- 36 sites in United States, Ukraine
- Volunteers
- 400 people
- Sponsor
- Anthera Pharmaceuticals
Stable Angina
Downstream Molecular Signals of P2Y12 Receptors in Hyporeactive Patients Under Clopidogrel Treatment A Possible Mechanism of HOTPR(High On-Treatment Platelet Reactivity)
The investigators designed the following experiment to observe the pattern of administration in vitro, which can be completely excluded liver enzyme cytochrome P450 metabolism under the influence and observe the relevant P2Y12…
- Trial name
- NCT03190005
- Testing
- clopidogrel
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Taipei City Hospital
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
Myocardial Ischemia(Implanted Drug-eluting Stents Because of Ischemic Heart Disease(Stable Angina, Acute Coronary Syndrome))
Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study): Retrospective and Prospective Follow-up Study
The investigator aimed to evaluate the long-term (up to 10 years) follow-up of the patients who enrolled the IVUS-XPL study (Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions)…
- Trial name
- NCT03866486
- Where
- South Korea
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
Stable Angina, Hypertension
Achievement of Goal Resting Heart Rate on B-blockers in Patients With Stable Angina and Hypertension
This is a multicenter survey of Russian data on target heart rate achievement in patients with stable angina and arterial hypertension who are currently treated with beta-blockers for at least 2 months and with no dose change for…
- Trial name
- Athena (NCT01321242)
- Where
- 6 sites in Russia
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
Coronary Disease
Thromboxane B2 and Platelet Function Testing as Measures of Aspirin Resistance in Hong Kong Chinese Patients
The hypotheses of the study are that the diagnostic accuracy of Multiplate® device for diagnosis of aspirin resistance is comparable to the serum TXB2 assay and that certain genetic polymorphisms and phenotypic factors…
- Trial name
- NCT04863053
- Testing
- Blood samples will be taken to assess platelet function. There is no change in treatment.
- Where
- Hong Kong
- Volunteers
- 266 people
- Sponsor
- Chinese University of Hong Kong
Stable Coronary Artery Disease, Acute Coronary Syndromes
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
- Conditions
- Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- NCT07588295
- Testing
- Optical Coherence Tomography assessment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Maria Cecilia Hospital
Stable Coronary Heart Disease
Use of Different Diagnostic Coronary Catheters Over the Radial Access - the UDDC - Radial Trial
There is no evidence from prospective randomized clinical trials regarding the performance of conventional (two-catheter-concept; TCC) versus one-catheter-concepts (OCC) for invasive coronary angiography over the radial access.
- Trial name
- UDDC (NCT02947542)
- Testing
- One-catheter concept, Standard catheter
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Ventricular Tachycardia, Coronary Artery Disease
Substrate Modification in Stable Ventricular Tachycardia in Addition to Implantable Cardioverter Defibrillator (ICD) Therapy
The main objective of this study is to compare the time from randomization to the first recurrence of any ventricular tachycardia (VT) in patients undergoing VT ablation (for stable VTs) and substrate ablation (for unstable VTs)…
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Left Ventricular Dysfunction
- Trial name
- VTACH (NCT00919373)
- Testing
- Substrate modification, VT ablation, ICD Implantation
- Where
- 16 sites in Czechia, Denmark and 2 more
- Volunteers
- 110 people
- Sponsor
- Abbott Medical Devices