Clinical trials: Stable Coronary Artery Disease
Stable Angina, Unstable Angina
Pivotal, Single-arm Clinical Trial to Assess the Efficacy and Safety of the MedHub AutocathFFR Software Device
Prospective (analysis of retrospective data), multi-center, observational, single-arm study. This structure was selected as the "worst case" due to the fact that it represents real life usage of invasive FFR measurement is…
- Conditions
- Stable Angina, Unstable Angina, NSTEMI
- Trial name
- AutocathFFR (NCT04861519)
- Testing
- Collecting invasive FFR measurements.
- Where
- 3 sites in Israel
- Volunteers
- 308 people
- Sponsor
- Medhub Ltd.
Stable Angina
Boston Scientific COMET Wire Validation Study
Summary of Study Aims To assess, in a randomised fashion: 1. performance of Boston Scientific Pressure Wire versus St Jude Pressure Wire 2. performance of Boston Scientific Pressure Wire versus Boston Scientific Pressure Wire 3.
- Trial name
- COMET (NCT02578381)
- Testing
- Boston Scientific Pressure Wire, Validation of Boston Scientific pressure wire
- Where
- 2 sites in United Kingdom
- Volunteers
- 106 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Unstable Angina, Non ST Segment Elevation Myocardial Infarction (NSTEMI)
Comparative Study of ALX-0081 Versus GPIIb/IIIa Inhibitor in High Risk Percutaneous Coronary Intervention (PCI) Patients
This is a multicenter, randomized and open-label Phase II study to compare the safety, tolerability and biological effectiveness of ALX-0081 versus the GPIIb/IIIa inhibitor ReoPro® in high risk PCI patients.
- Conditions
- Unstable Angina, Non ST Segment Elevation Myocardial Infarction (NSTEMI), Stable Angina (Associated With High Risk PCI)
- Trial name
- NCT01020383
- Testing
- ALX-0081, ReoPro®
- Where
- 39 sites in Austria, Belgium and 5 more
- Volunteers
- 364 people
- Sponsor
- Ablynx, a Sanofi company
Angina Pectoris
Efficacy and Safety of Intracoronary Ad5FGF-4 in Patients With Stable Angina (AGENT-3)
The purpose of this study is to determine whether a single intracoronary infusion of Ad5FGF-4 is effective in improving exercise capacity measured by exercise treadmill testing, angina functional class, patient symptoms, quality…
- Trial name
- NCT00346437
- Volunteers
- 416 people
- Sponsor
- Cardium Therapeutics
Stable Coronary Artery Disease
A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Coronary Artery Disease
The goal of this study is to find out if a drug called selatogrel (ACT-246475) can prevent platelets from binding together when administered by an injection under the skin in the thigh or in the belly.
- Trial name
- NCT03384966
- Testing
- Selatogrel
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 346 people
- Sponsor
- Viatris Innovation GmbH
Coronary Artery Disease (CAD)
PLASMA Trial: A Dose-Response Study of A-002 In Subjects With Stable Coronary Artery Disease
The study will be conducted at up to 80 centers worldwide and will be a double-blind randomized parallel group placebo controlled study among subjects with stable coronary artery disease (CAD).
- Trial name
- PLASMA (NCT00455546)
- Testing
- A-002
- Where
- 36 sites in United States, Ukraine
- Volunteers
- 400 people
- Sponsor
- Anthera Pharmaceuticals
Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes
Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease
An observational, retrospective, multicenter, blinded adjudication study to evaluate the clinical appropriateness of Percutaneous Coronary Intervention (PCI) indication and execution in patients with stable Coronary Artery…
- Conditions
- Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes, NSTEMI, Unstable Angina
- Trial name
- APACHE (NCT02748603)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Italian Society of Invasive Cardiology
Stable Angina
The PCI Choice Trial: a Pilot Randomized Trial of a Decision Aid for Patients With Stable Coronary Artery Disease
Despite several large clinical trials clearly establishing that coronary revascularization (i.e. percutaneous coronary intervention - PCI) does not prolong survival or prevent myocardial infarction (MI) for stable coronary artery…
- Trial name
- NCT01771536
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Mayo Clinic
Stable Angina, Unstable Angina, Silent Coronary Ischemia, Coronary Artery Disease
ISAR-DAPT (A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial)
This clinical trial studies patients treated with the Coroflex ISAR Stent for coronary artery disease in order for the objective of verifying the non-inferiority of results that among patients who were administered DAPT for 3…
- Trial name
- NCT02609698
- Testing
- Coroflex ISAR, 3 months DAPT, 6 months DAPT
- Where
- South Korea
- Volunteers
- 906 people
- Sponsor
- Ajou University School of Medicine
Ischemic Heart Disease
GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease
This study will evaluate the effect of GS-6615 in adults with chronic stable angina and coronary artery disease (CAD) receiving a stable daily dose of up to 2 antianginal medications.
- Trial name
- NCT02377336
- Testing
- GS-6615
- Sponsor
- Gilead Sciences
Coronary Artery Disease, Diabetes Mellitus
Safety and Efficacy of Empagliflozin for Patients With Diabetes Mellitus and Planned Percutaneous Coronary Interventions
Aim: To study the effectiveness and safety of empagliflozin as a preoperative preparation tool, as well as to improve the long-term prognosis of planned percutaneous coronary interventions in patients with type 2 diabetes
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- SAFARY (NCT04497792)
- Testing
- Empagliflozin 10Mg Tab, hypoglycemic therapy
- Volunteers
- 40 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Coronary Artery Disease, Type 2 Diabetes Mellitus
Direct Renin Inhibition Effects on Atherosclerotic Biomarkers
The investigators aim to assess if a new blood pressure medication, aliskiren, reduces various biomarkers of heart disease found in the blood in patients with a history of both heart disease and type 2 diabetes.
- Trial name
- NCT00818779
- Testing
- Aliskiren, Amlodipine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Texas Tech University Health Sciences Center
Atherosclerosis, Coronary Artery Disease
Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease
The purpose of this study is to investigate dose range, safety and efficacy of RVX000222 in subjects with stable coronary artery disease.
- Trial name
- ASSERT (NCT01058018)
- Testing
- RVX000222
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Resverlogix Corp
Coronary Artery Disease, Acute Coronary Syndrome
United Coronary Biobanks
The UNICORN consists of two collaborating biobanks, one in Utrecht and one in Singapore. From these two sites we include all patients who undergo a coronary catheterization for any reason.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction, Stable Angina
- Trial name
- UNICORN (NCT02126150)
- Where
- Singapore
- Volunteers
- 2,000 people
- Sponsor
- UMC Utrecht
Stable Ischemic Heart Disease
A Comparative Study of Different Treadmill Scores to Diagnose Coronary Artery Disease
Exercise treadmill test (ETT) is frequently done, inexpensive, relatively safe investigation for diagnosis of ischemic heart disease and prediction of exercise capacity.
- Trial name
- NCT02879032
- Where
- Bangladesh
- Volunteers
- 130 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Angina, Stable, Inflammation
The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris
This is a randomized, double-blind, placebo-controlled, adaptive clinical trial, which will assess the effect of DanshenDuofensuanyan[Danshen (a kind of Chinese herbal drug) extract] treatment on Lipoprotein associated…
- Trial name
- DOLPHIN (NCT02870764)
- Testing
- Dan-shen extract, Standard medical care
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Taizhou Fourth People's Hospital
Silent Myocardial Infarction, Stable Angina
Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII
The purpose of this study is to compare the effectiveness and safety, at 24 months, of the TITAN2 stent to any bare-metal stent (BMS) in Cobalt-Chromium in a population presenting an indication for these stents among 40% of which…
- Conditions
- Silent Myocardial Infarction, Stable Angina, Acute Coronary Syndrome
- Trial name
- EVIDENCE II (NCT01918150)
- Testing
- Titan 2 stents, Cobalt-Chromium Bare Metal Stents
- Where
- 42 sites in France
- Volunteers
- 1,350 people
- Sponsor
- Hexacath, France
Stable Angina, Angina, Unstable
DEDICA (Dose of HEparin During Coronary Angioplasty) Trial
International guidelines support the use of a full-dose heparin (anticoagulants) during coronary intervention. However, a lower dose of heparin may be adequate, thanks to advances in angioplasty techniques and the widespread use…
- Conditions
- Stable Angina, Angina, Unstable, Non-ST Elevation (NSTEMI) Myocardial Infarction
- Trial name
- DEDICA (NCT01694459)
- Testing
- Low-dose heparin, Standard dose heparin
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- San Filippo Neri General Hospital