Clinical trials: Stable Coronary Artery Disease
Acute Coronary Syndrome, Angina Pectoris, Unstable
Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome
Rationale: Thoracic complaints, possibly due to a cardiac ischemic cause are a diagnostic challenge in general practice. When an underlying ischemic cardiac condition (AMI (acute myocardial infarction), UAP (unstable angina…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Unstable, Angina Pectoris, Stable, Thoracic Diseases
- Trial name
- RAPIDA (NCT01826994)
- Testing
- heart type fatty acid binding protein testing
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 303 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity
No previous study has assessed the potential of ranolazine to interfere with levels of platelet reactivity in patients with coronary artery disease who are treated with dual antiplatelet therapy.
- Trial name
- ROMAN (NCT01490255)
- Testing
- Ranolazine, Amlodipine
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Stable Coronary Artery Disease
Computed Tomography Coronary Angiography Before Stent Implantation
The purpose of the study is to determine whether results of the computed tomography coronary angiography may be helpful in planning and performing percutaneous angioplasty in patients with stable angina pectoris.
- Trial name
- NCT01205425
- Testing
- PCI on the basis of coronary angiography, CT guided PCI
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Chronic Stable Angina
Effects of Ranolazine and Exercise on Daily Physical Activity Trial
The primary objective is to assess whether the increased angina threshold on ranolazine and subsequent higher training intensity will result in improved exercise tolerance and oxygen consumption; and greater than that observed…
- Trial name
- EREDA (NCT01948310)
- Testing
- Ranolazine, Aerobic Exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Stable Coronary Artery Disease
Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept
The main objective is to evaluate the efficacy and safety of treatment with 2 doses (80 and 160 mg) of Revacept versus placebo in patients with stable coronary artery disease undergoing PCI.
- Trial name
- ISAR-PLASTER (NCT03312855)
- Testing
- Revacept 80 mg, Revacept 160 mg
- Where
- 8 sites in Germany
- Volunteers
- 334 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Artery Disease, Stable Angina
Study Comparing Ticagrelor With Aspirin for Prevention of Vascular Events in Patients Undergoing CABG
The primary objective of this study ist to test the hypothesis that ticagrelor is superior to Aspirin (ASA) fort he prevention of major cardio- and cerebrovascular events (MACCE) in patients undergoing artery bypass operation.
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- TiCAB (NCT01755520)
- Testing
- Ticagrelor, Aspirin
- Where
- 29 sites in Austria, Germany and 1 more
- Volunteers
- 1,893 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Percutaneous Coronary Intervention
Pitavastatin Pre-Treatment Study in Patient With Elective PCI for Stable Angina Pectoris (PIPA)
Patients who is scheduled elective PCI are randomized to pitavastatin 4mg daily or without pitavastatin for 5 -7days before the procedure.
- Trial name
- NCT00786734
- Testing
- Pitavastatin
- Where
- South Korea
- Sponsor
- JW Pharmaceutical
Angina, Stable, Chest Pain
Acupuncture for Individuals With Stable Angina
This RCT aims to determine if it is possible to perform acupuncture on men and women diagnosed with stable angina who have symptoms, chest pain, and/or chest discomfort.
- Conditions
- Angina, Stable, Chest Pain, Microvascular Angina, Heart Failure
- Trial name
- AIMS-A (NCT02914834)
- Testing
- Acupuncture, Non-pain related video health education
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois Chicago
Coronary Heart Disease (CHD)
Single vs. Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Intervention With DCB-only Strategy (KONG-FREEDOM-I)
This investigator-initiated, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) utilizing a P2Y12 inhibitor compared to dual antiplatelet therapy (DAPT) in…
- Trial name
- KONG-FREEDOM-I (NCT07587099)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- 14 sites in China
- Volunteers
- 2,170 people
- Sponsor
- Gan Lijun
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Stable Ischemic Heart Disease
A Comparative Study of Different Treadmill Scores to Diagnose Coronary Artery Disease
Exercise treadmill test (ETT) is frequently done, inexpensive, relatively safe investigation for diagnosis of ischemic heart disease and prediction of exercise capacity.
- Trial name
- NCT02879032
- Where
- Bangladesh
- Volunteers
- 130 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University
Non-ST Segment Elevation Myocardial Infarction, Unstable Angina Pectoris
Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI
This randomized, open label, controlled, parallel group study is designed to test whether 2-day high dose atorvastatin administration before PCI and 30-day continuous intensive atorvastatin treatment is superior to usual care, in…
- Conditions
- Non-ST Segment Elevation Myocardial Infarction, Unstable Angina Pectoris, Stable Angina Pectoris
- Trial name
- ISCAP (NCT01293097)
- Testing
- Atorvastatin, Statin
- Where
- China
- Volunteers
- 2,884 people
- Sponsor
- Peking University First Hospital
Chronic Stable Angina
Multi-slice CT Coronary Angiography in Patients With Stable Angina
early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.
- Trial name
- NCT03963609
- Testing
- multisclice CT
- Volunteers
- 150 people
- Sponsor
- Benha University
Dyslipidemia, Angina (Stable)
Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community
The goal of this observational study is to evaluate whether a contactless camera-based technology, called remote photoplethysmography (rPPG), can accurately measure cardiovascular parameters and estimate cardiovascular risk in…
- Conditions
- Dyslipidemia, Angina (Stable), Coronary Artery Disease (CAD), Heart Disease
- Trial name
- NCT07502703
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Stable Coronary Disease
The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk
The study protocol is a single-arm, open label pilot study designed to evaluate the impact of PCSK-9 inhibition on coronary blood flow in patients with stable coronary artery disease.
- Trial name
- EMPOWER (NCT05152888)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease
Ticagrelor is an oral, reversibly-binding, direct-acting P2Y12 receptor antagonist used clinically for the prevention of atherothrombotic events in patients with acute coronary syndromes (ACS).
- Trial name
- NCT02514642
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
PAH
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)
This is a multicenter double-blind, placebo-controlled study to evaluate the safety, efficacy and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to 80 years of age with PAH.
- Trial name
- PAH (NCT03449524)
- Testing
- 75mg CXA-10, 150mg CXA-10
- Where
- 46 sites in United States, United Kingdom
- Volunteers
- 69 people
- Sponsor
- Complexa, Inc.
Cardiovascular Disease
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).
- Trial name
- OCEAN(a)-CCTA (NCT07293260)
- Testing
- Olpasiran
- Where
- 40 sites in United States, Australia and 9 more
- Volunteers
- 406 people
- Sponsor
- Amgen
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Clinical Efficacy of Permanent Internal Mammary Artery Occlusion in Stable Coronary Artery Disease
Cardiovascular diseases remain the number one cause of death globally, primarily consequence of myocardial infarction. Although widely used in stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) has not…
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Ischemia, Circulation, Collateral
- Trial name
- NCT03710070
- Testing
- Amplatzer vascular plug 4
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern