Clinical trials: Stable Coronary Heart Disease
Stable Angina, Unstable Angina, NSTEMI
Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease
This retrospective study will evaluate the coronary angiograms of approximately 100 patients who have undergone invasive angiography and fractional flow reserve (FFR).
- Trial name
- NCT06183294
- Testing
- Collecting invasive FFR measurements.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Clinical Efficacy of Permanent Internal Mammary Artery Occlusion in Stable Coronary Artery Disease
Cardiovascular diseases remain the number one cause of death globally, primarily consequence of myocardial infarction. Although widely used in stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) has not…
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Ischemia, Circulation, Collateral
- Trial name
- NCT03710070
- Testing
- Amplatzer vascular plug 4
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure, Systolic
A Novel Home-based Physical Activity Intervention for Stable Chronic Heart Failure Patients
The project focuses on heart failure (HF), a complex clinical syndrome of symptoms and signs that suggest the efficiency of the heart as a pump is impaired. Around 950,000 people in the UK have HF.
- Trial name
- PAHF (NCT03677271)
- Testing
- Physical Activity
- Volunteers
- 20 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Myocardial Infarction
Fractional Flow Reserve (FFR) Stability in Non-Culprit Vessels at ST Elevation Myocardial Infarction(STEMI)
It has been shown that if it can be accomplished within a 90 minute "door to balloon" time, opening an artery in an acute heart attack situation (ST elevation myocardial infarction or STEMI) is best treated with balloon…
- Trial name
- NCT01065103
- Testing
- FFR (Fractional Flow Reserve)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Coronary Artery Disease
Study to Evaluate the Association of Testosterone Levels With Coronary Artery Calcification
Coronary artery calcification (CAC) is a pandemic condition in elderly patients with coronary artery disease (CAD) and associated with worse prognosis.
- Trial name
- NCT02310659
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang University
Arterial Hypertension, Diabetes Mellitus
Azilsartan Medoxomil in Hypertensive pAtients With Stable Ischemic Heart Disease and DiabEtes MEllitus.
One-center, observational, non-interventional, prospective study of the efficacy of azilsartan medoxomil in patients with arterial hypertension associated with stable ischemic heart disease and type 2 diabetes mellitus.
- Conditions
- Arterial Hypertension, Diabetes Mellitus, Stable Chronic Angina
- Trial name
- AcADEME (NCT03539627)
- Testing
- Azilsartan Medoxomil 40 MG Oral Tablet [Edarbi]
- Where
- Russia
- Volunteers
- 184 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Atherosclerosis, Coronary
Effects of Rivaroxaban on Vascular FMD in Patients With Stable Atherosclerotic Vascular Diseases
The specific mechanistic benefit of rivaroxaban versus other FXa inhibitors on atherothrombotic events remain unclear. Therefore plan to initiate a prospective, randomized study to investigate the effect of rivaroxaban and…
- Trial name
- NCT06986369
- Testing
- Rivaroxaban 2.5 MG Oral Tablet [Xarelto]
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Coronary Artery Disease, Diabetes Mellitus
Safety and Efficacy of Empagliflozin for Patients With Diabetes Mellitus and Planned Percutaneous Coronary Interventions
Aim: To study the effectiveness and safety of empagliflozin as a preoperative preparation tool, as well as to improve the long-term prognosis of planned percutaneous coronary interventions in patients with type 2 diabetes
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- SAFARY (NCT04497792)
- Testing
- Empagliflozin 10Mg Tab, hypoglycemic therapy
- Volunteers
- 40 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Stable Coronary Artery Disease
RBD1119 in Coronary Artery Disease (CAD)
CAD is driven by atherosclerosis in the coronary arteries and is a major cause of myocardial infarction, heart failure, arrhythmias, and premature death.
- Trial name
- NCT07884136
- Testing
- RBD1119
- Where
- 16 sites in Poland, Sweden
- Volunteers
- 200 people
- Sponsor
- Ribocure Pharmaceuticals AB
Acute Myocardial Infarction (AMI), Stable Angina
Prospective Lifespan Cohort of Myocardial Infarction
This prospective cohort study aims to establish a lifespan cohort of myocardial infarction and build a standardized, multidimensional, and shareable disease-specific database by systematically integrating clinical phenotypes…
- Conditions
- Acute Myocardial Infarction (AMI), Stable Angina, Unstable Angina
- Trial name
- NCT07471763
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Fujian Provincial Hospital
Ischaemic Heart Disease
Hemodynamic Responses of Stable Ischemic Heart Disease Patients to a Comedy Session
It is known that laughter can bring benefits in terms of physiological and psychological parameters, in addition to improving the individual's quality of life.
- Trial name
- NCT02849067
- Testing
- Group Treatment, Group Control
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure, Renal Insufficiency
Effects of Chimeric Natriuretic Peptide Versus Placebo in Stable Heart Failure and Moderate Renal Dysfunction
The overall aim is to conduct a human physiologic study to assess the renal and neurohumoral effects of CD-NP vs placebo in older subjects with stable chronic systolic heart failure and moderate renal dysfunction.
- Trial name
- NCT01407900
- Testing
- CD-NP, 5% Dextrose in Water
- Sponsor
- John A. Schirger
Coronary Artery Disease, Stable Angina
Investigation of the Role of Hemodynamics in Re-stenosis of CABG Patients
CFD simulations in this study provide detailed hemodynamics information, which cannot be obtained from cardiac images alone. The investigators hypothesize that our proposed simulations will provide strong correlation between…
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- NCT02791087
- Testing
- Computed Tomography Angiography, Intra-operative graft flow rate measurement
- Where
- Singapore
- Volunteers
- 54 people
- Sponsor
- National Heart Centre Singapore
Chronic Heart Failure
Study to Investigate the Effects of Vitamin D Administration on Plasma Renin Activity in Patients With Stable Chronic Heart Failure
The renin-angiotensin system (RAS) is a regulatory system that plays an essential role in patients with chronic heart failure (CHF).
- Trial name
- VitD-CHF (NCT01092130)
- Testing
- Vitamin D
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease
Outpatient Percutaneous Coronary Intervention
To determine the safety and feasibility of same day discharge after elective coronary percutaneous intervention in a selected stable patient population.
- Trial name
- NCT00419055
- Testing
- Early discharge after percutaneous coronary intervenntion
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Stable Angina Pectoris, Acupoint Sensitization
The Diagnostic Value of Acupoint Sensitization Based on Stable Angina Pectoris
Investigators adopt cross-sectional study design to carry out the exemplary research in the aspects of disease diagnosis.This study is designed to confirm the hypothesis "acupoint sensitization is associated with a severity of…
- Conditions
- Stable Angina Pectoris, Acupoint Sensitization, Correlation Analysis, Diagnostic Value
- Trial name
- NCT03341663
- Testing
- Coronary angiography,Canadian Cardiovascular Society angina pectoris classification for the severity of angina and electronic Von Frey instrument for testing the degree of acupoint sensitization
- Where
- China
- Volunteers
- 183 people
- Sponsor
- West China Hospital
Stable Angina
Atorvastatin and Clopidogrel HIgh DOse in Stable Patients With Residual High Platelet Activity
The purpose of this study is to evaluate if high-dose (80mg/day) atorvastatin might exert an adjunctive anti-platelet effect compared to high-dose clopidogrel (150mg/day) in stable patients with high on-treatment reactivity…
- Trial name
- ACHIDO (NCT01335048)
- Testing
- atorvastatin and clopidogrel, Clopidogrel
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale Misericordia e Dolce
Transthorcic Echocardiography, Stable Angina Pectoris
TTE Improves Clinical Management of Stable Chest Pain
The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD).
- Conditions
- Transthorcic Echocardiography, Stable Angina Pectoris, Coronary Artery Disease, Major Adverse Cardiac Events
- Trial name
- TICM-SCP (NCT07063147)
- Testing
- TTE
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Tianjin Chest Hospital
Stable Angina, Unstable Angina
COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome Trials
Prospective, multi-centre, randomized, open-label, parallel comparisons to evaluate the incidence of bleedings (COSTA-Bleed) and the incidence of ischemic and bleeding events (COSTA-Outcome) following a therapy with the abluminal…
- Conditions
- Stable Angina, Unstable Angina, STEMI, NSTEMI
- Trial name
- COSTA (NCT02723981)
- Testing
- COMBO-Stent, Clopidogrel, Vitamin K Antagonist, Rivaroxaban, Dabigatran, Any drug eluting stent oder bare metal sent
- Where
- 10 sites in Germany
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Atherosclerosis, Stress
The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with…
- Conditions
- Atherosclerosis, Stress, Inflammation
- Trial name
- NCT04505865
- Testing
- Stress Reduction
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital