Clinical trials: Stable Coronary Heart Disease
Coronary Artery Disease, Stable Angina Pectoris
A Comparative Evaluation of the Extent of Neointima Formation at 1 Month and 2 Months After Implantation Using OCT
The objective of this study is a comparative evaluation of BuMA Supreme™ stent and of Xience V/Prime stent in terms of the extent of neointima formation at 1 or 2 months after implanting in relatively high bleeding risk patients…
- Conditions
- Coronary Artery Disease, Stable Angina Pectoris, Unstable Angina Pectoris
- Trial name
- NCT02747329
- Testing
- BuMA Supreme™ stent, Xience V/Prime stent
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Heart Failure
Spot Urinary Analysis to Assess Loop Diuretic Efficiency in Stable Heart Failure
The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical…
- Trial name
- DIPSTICK (NCT02288819)
- Testing
- Weight monitoring, Loop diuretic downtitration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Hasselt University
Chronic Heart Failure (CHF), Iron Deficiency
Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study
ERADAL-HF is a double blinded, multi-centre, prospective, randomized, three arm study, enrolled ambulatory patients with chronic heart failure [New York Heart Association (NYHA) class II/III], with iron deficiency [defined as…
- Trial name
- ERADAL-HF (NCT04225728)
- Testing
- Iron Sucrose IV, Ferric polymaltose hydroxide complex IM, Saline solution
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- CN NGANOU-GNINDJIO, MD, MSc
Stable Chronic Angina
Impact of Stent Length on Short Term Outcomes in Patients With Stable Coronary Disease Undergoing PCI
Impact of stent length on short term outcomes in patients with stable coronary artery disease undergoing PCI
- Trial name
- NCT03911895
- Testing
- Stent more than 26 mn length, Stent equal to or less than26 mn length
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Coronary Heart Disease, Stable Angina
Efficacy and Safety of Xueshuanxinmaining Tablet for the Treatment of Stable Angina Pectoris
This study is a randomized, double-blind, placebo-controlled, parallel clinical trial in Chinese population with stable angina pectoris.
- Trial name
- NCT04270279
- Testing
- Xueshuanxinmaining tablet, Nitroglycerin tablets
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Ischemic Heart Disease, Microvascular Coronary Artery Disease
The Cerebral-Coronary Connection (C3) Study
This is a prospective cohort blinded study with the aim to investigate the prevalence and clinical impact of coronary microcirculatory dysfunction (CMD) in patients with ischemic heart disease, and its association with cerebral…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Depression, Endothelial Dysfunction
- Trial name
- C3 (NCT04131075)
- Testing
- Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Salud Carlos III
Ischaemic Heart Disease, Coronary Heart Disease
Liraglutide to Improve corONary Haemodynamics During Exercise streSS
A single-centre double-blind placebo-controlled crossover randomised controlled trial to determine the physiological basis of glucagon-like peptide-1 receptor activation on exercise haemodynamics, as manifest through specific…
- Conditions
- Ischaemic Heart Disease, Coronary Heart Disease, Chronic Stable Angina
- Trial name
- LIONESS (NCT02315001)
- Testing
- Liraglutide
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- King's College London
Coronary Artery Disease
Influence of Lipid Lowering on Impaired Coronary Flow
This study assess in patients with stable chest pain and coronary artery disease (CAD) determined by coronary CTA whether cholesterol lowering with regression of coronary adverse plaque characteristics is associated with recovery…
- Trial name
- NCT05368545
- Testing
- High intensity lipid lowering
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Aarhus University Hospital
Ischemic Heart Disease, Ischemic Stroke
Study to Compare 2 Doses of Polycap Versus Single Dose of Polycap With or Without Pottasium
This is a randomized double blind 2x2 factorial controlled trial to evaluate efficacy tolerability of low strength Polycap versus two doses of low strength Polycap in patients with stable cardiovascular disease in reducing blood…
- Conditions
- Ischemic Heart Disease, Ischemic Stroke, Peripheral Vascular Disease, Type 2 Diabetes Mellitus
- Trial name
- TIPSK (NCT01404078)
- Testing
- Single Dose Polycap, Double dose Polycap
- Volunteers
- 518 people
- Sponsor
- St. John's Research Institute
Stable Angina, Silent Myocardial Ischemia
Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration of Dual Antiplatelet Therapy. Design of the Short Duration of Dual antiplatElet Therapy With SyNergy II Stent in Patients Older Than 75 Years Undergoing Percutaneous Coronary Revascularization.
The main objective of the SENIOR study is to establish the efficacy and safety of the everolimus eluting stent with a biodegradable abluminal polymer (SYNERGY II) associated with a short dual antiplatelet therapy (DAPT) in…
- Conditions
- Stable Angina, Silent Myocardial Ischemia, Acute Coronary Syndrome
- Trial name
- SENIOR (NCT02099617)
- Testing
- Percutaneous Coronary Intervention (PCI) with short DAPT duration with Synergy II stent, Percutaneous Coronary Intervention (PCI) with short DAPT duration with Omega stent, Percutaneous Coronary Intervention (PCI) with short DAPT duration with Rebel stent
- Where
- 44 sites in Belgium, Finland and 7 more
- Volunteers
- 1,200 people
- Sponsor
- Ceric Sàrl
Coronary Heart Disease, Physical Activity
Psychodynamic Motivation and Training Program
The purpose of this study is to examine the effectiveness of a Psychodynamic Motivation and Training Program (PMT) for the improvement of physical fitness in patients with stable coronary heart disease as compared to advice in…
- Trial name
- PMT (NCT01445808)
- Testing
- Psychodynamic Motivation and Training Program (PMT), Advice in Exercise Training (+Ex), Treatment as usual (TAU)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Johannes Gutenberg University Mainz
Coronary Heart Disease, Stable Angina Pectoris
Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation
The objective of this study is a comparative evaluation of Orsiro stent and of Resolute Integrity stent in terms of the extent of neointima formation at 4 months after implantation using optical coherence tomography (OCT).
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- Healing (NCT04465669)
- Testing
- Orsiro stents, Resolute Integrity® stents
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Chronic Stable Coronary Artery Disease
Syndrome Differentiation in the Management of Chronic Stable Coronary Artery Disease (SCAD) to Improve Quality
1.1 To build a TCM diagnosis and treatment database for chronic stable CAD; 1.2 To summarize the pattern of TCM medicine used and the effect of the medication in chronic stable CAD.
- Trial name
- NCT03018769
- Testing
- Chinese Herb
- Where
- 32 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast Nephropathy
Contrast-medium induced nephropathy (CIN) is a frequent and devastating complication of coronary angiography, occurring in 10-50% of cases.
- Trial name
- RIPC-CIN (NCT02674451)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Heart Injuries
Surgical Management of Blood in the Pericardial Sac After Penetrating Trauma
Penetrating wounds to the heart may present to the emergency unit with the presence of blood in the pericardial sac as determined on ultrasound.
- Trial name
- NCT00823160
- Testing
- Sternotomy, Subxyphoid window
- Where
- South Africa
- Volunteers
- 111 people
- Sponsor
- University of Cape Town
Angina Pectoris, Diabetes Mellitus, Type 2
Study Protocol for Rosiglitazone Versus Gliclazide in Diabetics With Angina
The principle objective of the trial is to compare rosiglitazone to gliclazide in patients with type 2 diabetes mellitus and chronic stable angina to see how the subjects' angina status changes.
- Trial name
- NCT00225342
- Testing
- Rosiglitazone, Gliclazide (Comparison drug)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Stable Coronary Artery Disease, Acute Coronary Syndromes
Coronary Laser Atherectomy Registry From an International Taskforce
This study is a prospective, investigator-initiated, multi-center, single arm, observational registry of performance of Excimer Laser Coronary Atherectomy (ELCA) in standard use cases of percutaneous coronary intervention (PCI).
- Trial name
- CLARIT (NCT07348341)
- Testing
- Excimer Laser Coronary Atherectomy (ELCA)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Ceric Sàrl
Stable Angina
A Study To Evaluate The Effect of T89(Dantonic®)On P450 Enzymes
Purpose: This study is to determine the effect of T89(Dantonic®)on P450 enzymes. This study will help determine which types of drugs may interact with T89.
- Trial name
- NCT01473888
- Testing
- T89(Dantonic)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tasly Pharmaceuticals, Inc.
Chronic Stable Angina
Management of Ischemic Heart Disease With Angiwell-XR (Ranolazine)
The rationale of MIDA trial is to determine efficacy and tolerability of ranolazine molecule among Pakistan population and obtain firsthand knowledge about the molecule ranolazine.
- Trial name
- MIDA (NCT03486561)
- Testing
- Ranolazine
- Volunteers
- 2,000 people
- Sponsor
- OBS Pakistan