Clinical trials: Stable Coronary Heart Disease
Coronary Heart Disease
SB-480848 in Major Adverse Cardiovascular Events - Integrated Summary of Efficacy and Safety From the STABILITY Trial (LPL100601) and the SOLID-TIMI-52 Trial (SB-480848/033)
The overall objective of this integrated analysis is to evaluate the clinical safety and efficacy of long-term treatment with darapladib enteric coated tablets, 160mg, as compared to placebo when added to standard of care in…
- Trial name
- NCT01636271
- Testing
- darapladib
- Volunteers
- 28,855 people
- Sponsor
- GlaxoSmithKline
Contrast Induced Nephropathy
Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography
As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing…
- Trial name
- CIN (NCT02113540)
- Testing
- Atorvastatin
- Where
- Iran
- Sponsor
- Isfahan University of Medical Sciences
Cardiovascular Disease
Cardiovascular Inflammation Reduction Trial
The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic…
- Trial name
- CIRT (NCT01594333)
- Testing
- Methotrexate
- Where
- 470 sites in United States, Canada and 1 more
- Volunteers
- 4,786 people
- Sponsor
- Brigham and Women's Hospital
Angina, Stable Ischemic Heart Disease
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple…
- Trial name
- LIVEBETTER (NCT05786417)
- Testing
- Clinician Discretion, Beta blocker, Calcium channel blocker
- Where
- 10 sites in United States
- Volunteers
- 741 people
- Sponsor
- Yale University
Angina Pectoris, Angina Pectoris, Stable
REDUCER-I: An Observational Study of the Neovasc Reducer™ System
The purpose of this study is to collect long term data of the Reducer System in subjects with refractory angina pectoris.
- Conditions
- Angina Pectoris, Angina Pectoris, Stable, Chronic Stable Angina
- Trial name
- NCT02710435
- Testing
- Reducer System
- Where
- 25 sites in Austria, Belgium and 7 more
- Volunteers
- 400 people
- Sponsor
- Shockwave Medical, Inc.
Amyloidosis Transthyretin, Athlete Heart
Exercise Effect on Transthyretin Stability
The goal of this study to investigate if exercise predisposes to transthyretin instability. The investigators will evaluate the effect of exercise on transthyretin biochemistry.
- Trial name
- NCT04986826
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Hypertension, Chronic Stable Angina
Bioequivalency Study of Amlodipine Tablets Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Amlodipine Besylate tablets, 10 mg, to Norvasc® Tablets, 10 mg (Pfizer) under fed conditions using a single-dose, randomized, 2-treatment, 2-period…
- Conditions
- Hypertension, Chronic Stable Angina, Vasospastic Angina
- Trial name
- NCT00601302
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Coronary Artery Disease, Stable Angina
Functional Assessment of Myocardial Ischemia by Intracoronary Electrocardiogram
In patients with chronic stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) targets hemodynamically significant coronary lesions, i.e., those thought to cause inducible ischemia.
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Ischemia
- Trial name
- FFRicECG (NCT03985241)
- Testing
- Functional Assessment of Myocardial Ischemia by icECG
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stable Coronary Artery Disease
A Pharmacodynamic Study With Ticagrelor in Hispanic Patients
The purpose of this study is to assess the pharmacodynamic effect of ticagrelor in Hispanic patients with stable coronary artery disease.
- Trial name
- NCT01523366
- Testing
- Ticagrelor, Clopidogrel
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
Chronic Ischemic Heart Disease
STable Coronary Artery Diseases RegisTry
Observational, prospective multicentric, national study, evaluating the diagnostic and therapeutic pathways of patient with cronic coronary artery disease followed in Italian cardiology centers.
- Trial name
- START (NCT03796741)
- Testing
- Data collection on Stable Ischemic heart disease
- Where
- 183 sites in Italy
- Volunteers
- 5,070 people
- Sponsor
- Heart Care Foundation
Ischemic Heart Disease, Stable Angina
DANish Multicenter STENT Trial
The purpose of the study was to evaluate procedural and late outcome of coronary artery stenting using 2 different unmounted stents
- Conditions
- Ischemic Heart Disease, Stable Angina, Unstable Angina
- Trial name
- NCT00139802
- Testing
- Coronary Stent Implantation
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Essential Hypertension, Chronic Stable Angina
Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg
The purpose of this study is to compare the pharmacokinetic characteristics and safety of dilatrend SR capsule 32mg and Dilatrend tablet 25mg in healthy male subjects.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- NCT01819870
- Testing
- Dilatrend SR capsule 32mg, Dilatrend IR tablet 25mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Atrial Fibrillation, Coronary Artery Disease
Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease
This study evaluates the efficacy and safety of Edoxaban with the combination of edoxaban and antiplatelet in patients with stable CAD (coronary artery stenosis ≥50% on medical treatment or revascularized stable CAD [≥ 12 months…
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Stable Angina, Stable Chronic Angina
- Trial name
- EPIC-CAD (NCT03718559)
- Testing
- Edoxaban Monotherapy, Edoxaban plus Single Antiplatelet Agent
- Where
- 18 sites in South Korea
- Volunteers
- 1,040 people
- Sponsor
- Gi-Byoung Nam
Cardiovascular Diseases, Myocardial Infarction
Exercise as a Life-long Medicine in Patients With Coronary Artery Disease
Exercise training is a core component in cardiac rehabilitation. Exercise adherence is, however, low after rehabilitation and the transition from supervised to unsupervised exercise is problematic for many patients with coronary…
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Angina (Stable)
- Trial name
- NCT02228603
- Testing
- high-intensity exercise training, web-based follow-up program, usual care
- Where
- 2 sites in Norway
- Volunteers
- 161 people
- Sponsor
- Norwegian University of Science and Technology
Heart Failure
Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart Failure
This study assess the safety/tolerability, PK/PD of LCZ696 in patients with stable heart failure.
- Trial name
- NCT00913653
- Testing
- LCZ696
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Stable Angina
Effectiveness of a Combination of Trimetazidine With One Hemodynamic Agent in Patients Recently Diagnosed With Stable Angina and Still Symptomatic Despite First Line Hemodynamic Therapy
The purpose of this study is to assess in recently diagnosed stable Angina patients symptomatic despite first line hemodynamic therapy, the effect of a combination of this hemodynamic agent with a metabolic one (trimetazidine).
- Trial name
- NCT06298045
- Where
- Romania
- Volunteers
- 600 people
- Sponsor
- Servier Affaires Médicales
Coronary Disease
CT Calcium Scoring in Suspected Stable Angina
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals.
- Trial name
- NCT01660594
- Testing
- CT calcium scoring
- Where
- United Kingdom
- Volunteers
- 705 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Heart Failure
Study to Investigate the Effects of Vitamin D Administration on Plasma Renin Activity in Patients With Stable Chronic Heart Failure
The renin-angiotensin system (RAS) is a regulatory system that plays an essential role in patients with chronic heart failure (CHF).
- Trial name
- VitD-CHF (NCT01092130)
- Testing
- Vitamin D
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- University Medical Center Groningen
Microvascular Coronary Artery Disease
A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI
Primary Objective: To assess the effects of SAR407899 on coronary vasomotor function using the coronary flow reserve (CFR) in participants with microvascular angina (MVA) and/or persistent stable angina despite angiographically…
- Trial name
- NCT03236311
- Testing
- SAR407899, Adenosine, Regadenoson
- Where
- 10 sites in United States, Denmark and 3 more
- Volunteers
- 10 people
- Sponsor
- Sanofi
Coronary Artery Disease, Plaque, Atherosclerotic
Coronary Artery Plaque Burden in Stable Angina and Non-obstructive Coronary Artery Disease
Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations.
- Trial name
- NCT04009421
- Testing
- Coronary artery plaque assessment by CT coronary angiography QAngio CT RE
- Where
- Norway
- Volunteers
- 1,400 people
- Sponsor
- University of Bergen