Clinical trials: Stable Coronary Heart Disease
Chronic Coronary Syndrome, Myocardial Ischemia
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires.
- Conditions
- Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
- Trial name
- PERFORM-CCS (NCT05865600)
- Testing
- Optimization of guideline-directed medical therapy, Immediate referral for invasive coronary angiography, 3-months delayed referral for invasive coronary angiography
- Where
- Denmark
- Volunteers
- 570 people
- Sponsor
- Gødstrup Hospital
Coronary Artery Disease, Diabetes Mellitus
Safety and Efficacy of Empagliflozin for Patients With Diabetes Mellitus and Planned Percutaneous Coronary Interventions
Aim: To study the effectiveness and safety of empagliflozin as a preoperative preparation tool, as well as to improve the long-term prognosis of planned percutaneous coronary interventions in patients with type 2 diabetes
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- SAFARY (NCT04497792)
- Testing
- Empagliflozin 10Mg Tab, hypoglycemic therapy
- Volunteers
- 40 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Type 2 Diabetes Mellitus, Coronary Artery Disease
Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease
Type 2 diabetes is associated with a markedly increased risk for atherosclerotic coronary arteries and cerebrovascular diseases.
- Trial name
- NCT01038050
- Testing
- Ginkgo Biloba Extract (GBE)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Coronary Artery Disease
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to 30% of patients.
- Trial name
- NCT05332262
- Testing
- Assessment of platelet reactivity, Troponin measurement
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Florida
Coronary Heart Disease, Stable Angina
Percutaneous Coronary Intervention Versus Medical Treatment for Stable Angina Pectoris
Patients with ischemic heart disease and symptoms due to lack of oxygen to the heart on exertion (stable angina pectoris) are usually treated by either percutaneous coronary intervention (PCI) or optimal medical therapy (OMT)…
- Conditions
- Coronary Heart Disease, Stable Angina, Ischemic Heart Disease
- Trial name
- DANANGINA (NCT04496648)
- Testing
- Percutaneous Coronary Intervention
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Herlev and Gentofte Hospital
Coronary Artery Disease, Atherosclerosis, Coronary
HIV Infection And Evolvement of Atherosclerotic Plaque
In a prospective multi-center observational study, 200 HIV-infected patients treated with antiretroviral treatment (ART) and who suffered from coronary artery disease (CAD) will be enrolled.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Hiv, HIV Infections
- Trial name
- HIVE (NCT04810364)
- Testing
- Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 2 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
Heart Failure, Renal Insufficiency
Effects of Chimeric Natriuretic Peptide Versus Placebo in Stable Heart Failure and Moderate Renal Dysfunction
The overall aim is to conduct a human physiologic study to assess the renal and neurohumoral effects of CD-NP vs placebo in older subjects with stable chronic systolic heart failure and moderate renal dysfunction.
- Trial name
- NCT01407900
- Testing
- CD-NP, 5% Dextrose in Water
- Sponsor
- John A. Schirger
Sleep-disordered Breathing, Chronic Heart Failure
Validation of the "ApneaScan" Algorithm for the Detection of Sleep Disordered Breathing in Chronic Heart Failure
A prospective observational multi-centre study for the validation of the ApneaScan algorithm (integrated in ICD devices (with or without cardiac resynchronization therapy function) of the "Incepta" series for the screening of…
- Trial name
- VASA (NCT01979120)
- Where
- 14 sites in Austria, Germany and 2 more
- Volunteers
- 200 people
- Sponsor
- Dr. Christoph Schukro
Coronary Heart Disease, Stable Angina Pectoris
BuMA OCT Study(A Comparative Evaluation of the Extent of Neointima Formation at 3 Months After Implantation Using OCT)
The objective of this study is a comparative evaluation of BuMA stent and of EXCEL stent in terms of the extent of neointima formation at 3 months after implantation using OCT.
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Unstable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- NCT01752582
- Testing
- BuMA stent, EXCEL stent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Stable Ischemic Heart Disease
TherApy in stabLe Coronary Artery dIsease Patients According to Clinical GuideliNes (ALIGN)
The aim of this prospective cohort study is to assess the quality of therapy in patients with stable ischemic heart disease (IHD) who had never applied for specialized medical care for the last 3 years and try to accord their…
- Trial name
- NCT04162561
- Testing
- Patients with documented IHD
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- National Research Center for Preventive Medicine
Angina Pectoris, Stable
Effects of Ivabradine on Residual Myocardial Ischemia After PCI
This is a randomized pharmacological study evaluating the effects of ivabradine in patients with residual angina after PCI. The role of ivabradine in patients with angina, without systolic dysfunction, is not yet clear.
- Trial name
- NCT03866395
- Testing
- Ivabradine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Policlinico Umberto I
Coronary Heart Disease
Efficacy of Dun Ye Guan Xin Ning Tablet in Patients With Stable Angina Pectoris
This registry is designed to investigate factors affecting the efficacy of Dun Ye Guan Xin Ning tablet on patients with stable angina.
- Trial name
- NCT03198091
- Testing
- Dun Ye Guan Xin Ning
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University First Hospital
Coronary Artery Disease, Atherosclerotic Plaque
STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB)
This study aims to investigate whether DCB angioplasty, compared to statin-based medical treatment alone, will lead to more reduction in plaque lipid burden as assessed by near infrared spectroscopy (NIRS) at 6-9 months following…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, De Novo Stenosis
- Trial name
- STABLE-DCB (NCT05438121)
- Testing
- SeQuent Please Neo
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Korea University Ansan Hospital
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Migraine Disorders, Heart Disease
Telcagepant (MK-0974) Treatment of Migraine in Participants With Stable Vascular Disease (MK-0974-034)
The purpose of this study is to evaluate the safety and efficacy of telcagepant in the treatment of acute migraine in participants with stable vascular disease.
- Conditions
- Migraine Disorders, Heart Disease, Cerebrovascular Accident, TIA (Transient Ischemic Attack)
- Trial name
- NCT00662818
- Testing
- Telcagepant, Acetaminophen/Paracetamol
- Volunteers
- 165 people
- Sponsor
- Merck Sharp & Dohme LLC
Stable Angina, Angina, Unstable
DEDICA (Dose of HEparin During Coronary Angioplasty) Trial
International guidelines support the use of a full-dose heparin (anticoagulants) during coronary intervention. However, a lower dose of heparin may be adequate, thanks to advances in angioplasty techniques and the widespread use…
- Conditions
- Stable Angina, Angina, Unstable, Non-ST Elevation (NSTEMI) Myocardial Infarction
- Trial name
- DEDICA (NCT01694459)
- Testing
- Low-dose heparin, Standard dose heparin
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- San Filippo Neri General Hospital
Coronary Artery Disease, Acute Myocardial Infarction
HOST - DAPT Duration According the Bleeding Risk
Dual antiplatelet agent therapy (DAPT) is essential in treating PCI patients. DAPT can minimize thrombotic adverse events that occur not only at the stented lesion, but along the whole coronary tree.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Stable Angina
- Trial name
- HOST-BR (NCT05631769)
- Testing
- Dual antiplatelet agent duration
- Where
- South Korea
- Volunteers
- 4,900 people
- Sponsor
- Seoul National University Hospital
Eisenmenger Complex
Real World Difference After Changing Medication From Nonselective to Selective Endothelin Receptor Antagonist in Stable Eisenmenger Syndrome
In this study, the investigator will evaluate the treatment effects and safety, patient compliance of Ambrisentan in Eisenmenger syndrome in PAH patients who have been previously treated with Bosentan.
- Trial name
- NCT04732650
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Stable Angina, Unstable Angina
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial
We had little experience in coronary intervention with recently introduced newer drug-eluting stent (DES) platforms, despite great anticipation, and optimal duration of dual antiplatelet therapy (DAPT) for these stent systems…
- Conditions
- Stable Angina, Unstable Angina, Non-ST Segment Elevation Myocardial Infarction
- Trial name
- HOST-IDEA (NCT02601157)
- Testing
- 3-months DAPT, 1-year DAPT
- Where
- 12 sites in South Korea
- Volunteers
- 2,173 people
- Sponsor
- Seoul National University Hospital
Platelet Dysfunction
The Effect of Cocoa on Platelet Function Profiles in Patients
The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not…
- Trial name
- ECLAIR (NCT04554901)
- Testing
- Cocoa
- Where
- Trinidad and Tobago
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies