Clinical trials: Stable Coronary Heart Disease
Stable Angina, Ischemic Heart Disease
Drug Coated Balloon for Side Branch Treatment vs. Conventional Approach in True Bifurcation Coronary Disease: PRO-DAVID
Bifurcation lesions (BL) on coronary arteries account for 15-20 % of all performed percutaneous coronary interventions (PCI). Preferred approach for treatment of most bifurcation lesions is the stepwise provisional stent strategy…
- Conditions
- Stable Angina, Ischemic Heart Disease, Coronary Artery Disease, Unstable Angina
- Trial name
- PRO-DAVID (NCT04403048)
- Testing
- Provisional DCB approach PCI procedure, Standard provisional approach PCI procedure
- Volunteers
- 800 people
- Sponsor
- Clinical Hospital Center Rijeka
Heart Failure With Reduced Ejection Fraction
Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification
A number of large randomized studies have demonstrated the importance of left ventricle ejection fraction (LV EF) for ventrucular tachyarhrythmia's (VT) prediction.
- Trial name
- PERFECT (NCT05539898)
- Testing
- ICD implantation
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- Astrakhan Federal Centre For Cardiac Surgery
Multivessel Coronary Artery Disease
Revascularization With BVS or CABG in Patients With Advanced CAD
The purpose of the study is to investigate the extent of ischemia and left ventricular function in cardiovascular magnetic resonance (CMR), as well as patency of coronary arteries and grafts in coronary computed tomography…
- Trial name
- RELEASE-BVS (NCT02334826)
- Testing
- PCI -BVS, CABG
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- Poznan University of Medical Sciences
Chronic Stable Angina
Yinxingmihuan Oral Solution in Treatment of Chest Pain After PCI
A prospective, multi-center, double-blind, randomized, placebo-controlled trial is conducted to evaluate the efficacy and safety of Yinxingmihuan oral solution in the treatment of chest pain after percutaneous coronary…
- Trial name
- NCT06224582
- Testing
- Yinxingmihuan oral solution
- Where
- China
- Volunteers
- 320 people
- Sponsor
- China National Center for Cardiovascular Diseases
Patients With Stable Coronary Artery Disease
Acute Hemodynamic and Biological Effects of ECP and Exercise
The purpose of this study in humans with stable coronary artery disease (CAD) treatable by percutaneous intervention (PCI) is to evaluate the efficacy of Enhanced External Counterpulsation (EECP) with regard to coronary…
- Trial name
- NCT02014090
- Testing
- Hemodynamic and biological measurements
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Ischemia, Ischemic Reperfusion Injury
Remote Ischemic Preconditioning in Elective Percutaneous Interventions
Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion.
- Trial name
- NCT02581618
- Testing
- remote ischemic preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Trakya University
Heart Failure
Digoxin Withdrawal in Stable Heart Failure
Heart failure is a chronic condition in which the heart fails to function as a pump to move blood around the body. This sets up a complex physiologic response to compensate, which include activation of many hormonal mechanisms…
- Trial name
- NCT01398371
- Testing
- Withdrawal of digoxin, Digoxin
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- The Alfred
Coronary Artery Disease
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to 30% of patients.
- Trial name
- NCT05332262
- Testing
- Assessment of platelet reactivity, Troponin measurement
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Florida
Coronary Artery Disease Premature, Angina, Stable
Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
The new global guidelines from the World Health Organization on air quality provide evidence of the damage that air pollution inflicts on human health at even lower concentrations than previously thought.
- Conditions
- Coronary Artery Disease Premature, Angina, Stable, Acute Coronary Syndrome, MINOCA
- Trial name
- AIRHEART (NCT06464042)
- Where
- Spain
- Volunteers
- 4,272 people
- Sponsor
- pablo Juan-Salvadores
Cardiovascular Risk Factor
Effect of a Low Calorie Diet Containing Nuts on Systemic and Vascular Inflammation
Accumulating evidence from prospective observational studies and a large clinical trial suggests that nut intake lowers the risk of cardiovascular disease (CVD).
- Trial name
- NCT04078919
- Testing
- Nut consumption, Low calorie diet
- Where
- Iran
- Volunteers
- 67 people
- Sponsor
- Shahid Beheshti University
Coronary Artery Disease
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is estimated based on two angiographic projections.
- Trial name
- NCT03729739
- Testing
- QFR-based diagnostic strategy, FFR-based diagnostic strategy
- Where
- 35 sites in Denmark, France and 9 more
- Volunteers
- 2,001 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Artery Disease
Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity
Patients with coronary artery disease (CAD) are often treated with dual antiplatelet therapy (DAT), including aspirin and clopidogrel, to prevent from recurrent atherothrombotic events.
- Trial name
- PEARL (NCT01567774)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Ischemic Heart Disease
Multicenter Registry for Angiography-Derived Quantitative Flow Ratio
1. to investigate the feasibility and diagnostic performance of contrast quantitative flow ratio (QFR) for identifying the functional significance of intermediate degree stenotic lesions in all-comer patients with coronary artery…
- Trial name
- QFRRegistry (NCT03791788)
- Testing
- QFR assessment
- Where
- 5 sites in South Korea
- Volunteers
- 524 people
- Sponsor
- Samsung Medical Center
Myocardial Bridge of Coronary Artery, Myocardial Bridge
Myocardialbridge Bypass Graft Surgery Efficacy Verification
Myocardial Bridge Bypass Graft surgery is introduced to relieve the unmedical symptoms of patients with long-segment or deep myocardial bridge, clinical outcomes will be collected to verify the effectiveness of the surgery.
- Conditions
- Myocardial Bridge of Coronary Artery, Myocardial Bridge, Myocardial Bridging, Myocardial Infarction
- Trial name
- NCT06857838
- Testing
- MBBG, MB CABG, MB unroof
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xi'an International Medical Center Hospital
Stable Angina
Correlational Study on the Biomarkers Application to the Prediction and Diagnosis of Cardiovascular Diseases
Through the literature review , we pick out a series of forward-looking biological indicators as follows : 1. NGAL 2. Cystatin C: 3. Galectin-3: 4. Copeptin: 5. MR-Pro ANP: 6. sST2:
- Trial name
- NCT02179047
- Testing
- coronary angiography
- Where
- Taiwan
- Volunteers
- 214 people
- Sponsor
- Taipei City Hospital
Stable Angina
Safety and Efficacy of Intracoronary Ad5FGF-4 in Patients With Stable Angina
The purpose of this study is to determine whether a single intracoronary infusion of Ad5FGF-4 is effective in improving exercise capacity measured by exercise treadmill testing, angina functional class, patient symptoms, quality…
- Trial name
- AGENT-4 (NCT00185263)
- Volunteers
- 116 people
- Sponsor
- Cardium Therapeutics
Stable Coronary Artery Disease
A Study of the Antiplatelet Effects Comparing Ticagrelor (Ticag. - AZD6140) With Clopidogrel (Clop.) Responder and Non-responders
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet medication, affects platelets. Anti-platelet agents are medications that block the formation of blood clots by preventing the clumping of…
- Trial name
- RESPOND (NCT00642811)
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Coronary Artery Disease
Comparison of UFR With QFR in Stable Coronary Artery Disease
Quantitative flow reserve (QFR), derived from coronary angiography, has shown high accuracy in detecting significant lesions. Ultrasonic flow ratio (UFR), a new development from IVUS, integrates physiological estimation with…
- Trial name
- NCT06322355
- Testing
- Coronary angiography, Fractional Flow Reserve measurement, Intravascular ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Zhongshan Hospital
Angina, Stable
Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.
This study evaluates the addition of the CADScorSystem to a standard Diamond-Forrester score guided rule-out strategy in ambulatory patients referred with symptoms suggestive of stable coronary artery disease.
- Trial name
- FILTER-SCAD (NCT04121949)
- Testing
- CADScor®System
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 2,016 people
- Sponsor
- Bispebjerg Hospital
Angina, Stable, Inflammation
The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris
This is a randomized, double-blind, placebo-controlled, adaptive clinical trial, which will assess the effect of DanshenDuofensuanyan[Danshen (a kind of Chinese herbal drug) extract] treatment on Lipoprotein associated…
- Trial name
- DOLPHIN (NCT02870764)
- Testing
- Dan-shen extract, Standard medical care
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Taizhou Fourth People's Hospital