Clinical trials: Stable Ischemic Heart Disease
Stable Angina
Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Background: A total of 25-50% of patients with stable coronary atherosclerosis treated with metallic stent implantation remain with effort angina despite optimal medical treatment and absence of stent restenosis at 1 year.
- Trial name
- BVS-Flow (NCT02738658)
- Testing
- Bioresorbable vascular scaffold, Everolimus-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Coronary Artery Diseases, Myocardial Infarction
The Efficacy of Influenza Vaccine in Reducing Cardiovascular Events in Patients With Coronary Artery Diseases
Influenza vaccine reduces the cardiovascular events in post-myocardial infarction (MI) patients and in those with stable angina (SA).
- Conditions
- Coronary Artery Diseases, Myocardial Infarction, Stable Angina
- Trial name
- IVCAD (NCT00607178)
- Testing
- influenza vaccine
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Coronary Artery Disease, Acute Coronary Syndrome
PGD2 Formation in Vascular Injury
To investigate the biosynthesis of PGD2 during percutaneous transluminal coronary angioplasty (PTCA) procedure.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Stable Angina
- Trial name
- PGD2 (NCT01001260)
- Testing
- No ASA, Low dose ASA, 325 mg ASA
- Volunteers
- 51 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease, Ischemic Heart Disease
Coronary and Structural Interventions Ulm - Coronary Chronic Total Occlusions
To evaluate the long-term results after recanalization of coronary chronic total occlusions.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Stable Angina
- Trial name
- CSI-Ulm-CTO (NCT02162082)
- Testing
- stent or scaffold
- Where
- Germany
- Volunteers
- 198 people
- Sponsor
- University of Ulm
Percutaneous Coronary Intervention (PCI), Drug Coated Balloon
Registry of Coronary Disease Outcomes Revascularizing With Drug-Coated Balloons
The primary aim of this registry is to systematically collect and analyze real-world data on all patients undergoing PCI with the Protégé paclitaxel-eluting DCB to evaluate procedural outcomes, long-term efficacy, and safety…
- Conditions
- Percutaneous Coronary Intervention (PCI), Drug Coated Balloon, Paclitaxel, CAD - Coronary Artery Disease
- Trial name
- RECORD-DCB (NCT07231835)
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Angina, Stable
Efficacy and Safety Study of Guanxin Shutong Capsule to Treat Chronic Stable Angina
Compared with placebo, assess of the efficacy and safety of Guanxin Shutong capsule to treat chronic stable angina (syndrome of blood stasis resistance), and the result will be used for the basis of later Ⅳ clinical trial.
- Trial name
- NCT02280850
- Testing
- Guanxin Shutong Capsule, nitroglycerine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shaanxi Buchang Pharmaceutical Co., Ltd
Stable Angina, Coronary Stenosis
The Treatment of Coronary De-novo Lesions With the Elutax Paclitaxel-eluting Balloon Alone, a Pilot Study
A randomised open-label pilot study to assess the safety and efficacy of treatment with a drug eluting balloon alone in coronary de novo lesions).
- Trial name
- EXPEL (NCT01899235)
- Testing
- drug eluting balloon, drug eluting stent
- Where
- Denmark
- Sponsor
- Aalborg University Hospital
Stable Angina, Unstable Angina
Impact of Low Frame Rate Fluoroscopy and Cine-angiography on Reducing Operator and Patient Dose
The investigators sought to investigate the efficacy of low frame rate (fluoroscopy at 7.5 frames per second (FPS) and Cine at 10 pulse per second (PPS) vs.
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT02574949
- Testing
- Radiation: 15 FPS Cine 15 PPS, Radiation: 7.5 low Frame rate, Low Cine
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Stable Angina, Chronic Total Occlusion of Coronary Artery
A Placebo-controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention for the Relief of Stable Angina
ORBITA-CTO Pilot is a double blinded randomised placebo-controlled trial comparing the effects of chronic total occlusion percutaneous coronary intervention versus placebo on symptoms of angina in patients with background optimal…
- Trial name
- ORBITA-CTO (NCT05142215)
- Testing
- Percutaneous coronary intervention
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Artery Disease, Exercise
Effect of Long-term Exercise on Haemostasis and Inflammation in Patients With Coronary Artery Disease
Introduction: Regular exercise training improves prognosis in patients with coronary artery disease (CAD). This study investigates whether the beneficial effects of exercise can be partly explained by favourable changes in…
- Conditions
- Coronary Artery Disease, Exercise, Inflammation, Hemostasis
- Trial name
- NCT04268992
- Testing
- Long-term exercise
- Where
- Faroe Islands
- Volunteers
- 142 people
- Sponsor
- Aarhus University Hospital
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Chronic Total Occlusion, Coronary Artery Disease
Risk Factors and Outcomes in Coronary Chronic Total Occlusion
This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
- Trial name
- NCT06137521
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Chronic Coronary Syndrome, Chronic Coronary Total Occlusion
Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease
This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.
- Conditions
- Chronic Coronary Syndrome, Chronic Coronary Total Occlusion, Coronary Arterial Disease (CAD), Stable Chronic Angina
- Trial name
- BNP-CAD (NCT07013344)
- Testing
- BNP
- Where
- 2 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Ospedale San Raffaele
Myocardial Infarction, Stable Angina
Barts Revascularisation Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading cause of mortality worldwide. With advances in technology and our understanding of cardiac disease, we can now treat CAD using…
- Trial name
- NCT05255705
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Chronic Stable Angina
Evaluating Dose-proportionality of Dilatrend Suspended-Release Capsule
This study is designed to evaluate dose-proportionality of Dilatrend SR 8mg, 16mg, 32mg, 64mg, 128mg in healthy male volunteers.
- Trial name
- NCT01369472
- Testing
- Dilatrend SR capsule
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Coronary Artery Disease
Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain
To determine whether, in a population of patients presenting to the rapid access chest pain clinic (RACPC), routine FFRct (Fractional Flow Reserve Computed Tomography) as a default test is superior in terms of resource…
- Trial name
- FORECAST (NCT03187639)
- Testing
- FFRct, Standard care
- Where
- United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Stable Angina Pectoris, Coronary Artery Disease
1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease
1. Objective Objective: > The purpose of this study is to evaluate whether a short-term (1-month) dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) is non-inferior to the standard 6-month DAPT in…
- Trial name
- D-ONE (NCT07592507)
- Testing
- 1-Month DAPT followed by SAPT, 6-Month DAPT followed by SAPT
- Volunteers
- 1,484 people
- Sponsor
- Daejeon St. Mary's hospital
Stable Angina, Myocardial Infarction
Safety Evaluation of Clopidogrel Sulfate in Patients With Stable Angina/Old Myocardial Infarction to Whom Percutaneous Coronary Intervention is Being Planned
Primary objective: To evaluate whether 12 weeks of clopidogrel is superior to ticlopidine in terms of lower risk of the safety events of interest in patients with stable angina (SA) or old myocardial infarction (OMI) to which…
- Trial name
- CLEAN (NCT00821834)
- Testing
- clopidogrel (SR25990), ticlopidine
- Where
- Japan
- Volunteers
- 1,003 people
- Sponsor
- Sanofi
Adrenergic Beta-Antagonists, Stable Angina Pectoris
A Randomized, Two-arm, Open Label Study to evalUate the Effect of a Smart Phone-based Patient Support Tool On Patient AdheRence of Treatment in Stable Angina Patients Prescribed Beta-blockers in China (SUPPORT)
The present study aims to enhance the adherence of beta-blockers by Patient Support Tool through a smart phone application and a wristband, subsequently reduce the risk of angina attacks in patients with stable angina pectoris.
- Conditions
- Adrenergic Beta-Antagonists, Stable Angina Pectoris, Medication Adherence, Mobile Applications
- Trial name
- NCT03794713
- Testing
- Patient support tool
- Volunteers
- 432 people
- Sponsor
- Shenyang Northern Hospital
Coronary Artery Disease, Diabetes Mellitus
Safety and Efficacy of Empagliflozin for Patients With Diabetes Mellitus and Planned Percutaneous Coronary Interventions
Aim: To study the effectiveness and safety of empagliflozin as a preoperative preparation tool, as well as to improve the long-term prognosis of planned percutaneous coronary interventions in patients with type 2 diabetes
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- SAFARY (NCT04497792)
- Testing
- Empagliflozin 10Mg Tab, hypoglycemic therapy
- Volunteers
- 40 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia