Clinical trials: Stable Ischemic Heart Disease
Coronary Artery Disease
Etomidate Versus Propofol in CABG Surgery
The objective of this single-blinded randomized controlled interventional clinical trial is to learn about the efficacy and long-term safety of etomidate compared to propofol as an anesthesia induction agent in patients…
- Trial name
- ETOPRO (NCT06068764)
- Testing
- Etomidate, Propofol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hartford Hospital
Angina Pectoris
Efficacy and Safety of Lacidipine in Chronic Stable Angina
The aim of this study was to explore whether lacidipine at doses of 2 mg, 4 mg and 6 mg decreased the symptoms of angina, compared to placebo in patients with chronic stable angina
- Trial name
- NCT02232607
- Testing
- Lacidipine, low dose, Lacidipine, medium dose, Lacidipine, high dose
- Volunteers
- 283 people
- Sponsor
- Boehringer Ingelheim
Angina, Stable
Artificial Intelligence in ANOCA
Angina pectoris is diagnosed in >180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or…
- Trial name
- (AI)NOCA (NCT06387693)
- Testing
- Holter monitoring, intracoronary ECG
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease
Effects of Different Doses of Ticagrelor on Platelet Aggregation and Endothelial Function in Diabetic Patients With Stable Coronary Artery Disease
Ticagrelor is an oral, reversibly-binding, direct-acting P2Y12 receptor antagonist used clinically for the prevention of atherothrombotic events in patients with acute coronary syndromes (ACS).
- Trial name
- NCT02889549
- Testing
- ticagrelor, clopidogrel
- Where
- 2 sites in United States, China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
Platelet Reactivity
Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.
Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients.
- Trial name
- NCT03679091
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation, Venous Thromboembolism
Prothrombin Times Outside the Therapeutic Range in Otherwise Stable Patients
Warfarin is very effective for the prevention of blood clots (thrombosis). A test of coagulation, the prothrombin time (PT) is used to monitor the effect.
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Ischemic Stroke, Myocardial Infarction
- Trial name
- FORESPEAK-0 (NCT00814177)
- Testing
- warfarin
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Hamilton Health Sciences Corporation
Diabetes Mellitus
Sex Differences in the Risk of Cardiovascular Diseases Associated With Diabetes
To evaluate the risk of cardiovascular events associated with medication use for controlling blood glucose, blood pressure and cholesterol levels in men and women with diabetes treated in primary care
- Trial name
- NCT02542774
- Testing
- No intervention is given.
- Where
- United Kingdom
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Essential Hypertension, Chronic Stable Angina
Observational Study to Evaluate the Safety of DILATREND SR Cap. in Korean Patients With Essential Hypertension, Chronic Stable Angina and Congestive Heart Failure
The purpose of this study is to Evaluate the Safety of DILATREND SR Cap. in Korean Patients with Essential hypertension, Chronic stable angina and Congestive heart failure for 52 weeks.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- DELIGHT (NCT03063697)
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Coronary Artery Disease
Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent
To treat patients with stable coronary artery disease, elective percutaneous coronary intervention (PCI) will be performed with the use of an everolimus-eluting cobalt- chromium stent (everolimus-eluting stent: EES, Xience Prime…
- Trial name
- NCT02014818
- Testing
- CoCr-EES
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kobe University
Stable Angina Pectoris
Prevalence and Prognostic Value of Unrecognized Myocardial Injury in Stable Coronary Artery Disease (PUMI)
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
- Trial name
- PUMI (NCT01257282)
- Where
- 6 sites in Sweden
- Volunteers
- 275 people
- Sponsor
- Uppsala University
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
The Influence of Smoking Status on Prasugrel and Clopidogrel Treated Subjects Taking Aspirin and Having Stable Coronary Artery Disease
This study is being conducted to determine if smoking will influence the platelet aggregation inhibition ability of clopidogrel and prasugrel.
- Trial name
- NCT01260584
- Testing
- Prasugrel, Clopidogrel
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- Daiichi Sankyo
Stable Angina Pectoris, Coronary Artery Disease
Comprehensive Cardiac CT Versus Exercise Testing in Suspected Coronary Artery Disease (2)
Multi-center, randomized-controlled trial comparing a comprehensive cardiac CT protocol with standard stress testing in patients with stable chest pain complaints.
- Trial name
- CRESCENT2 (NCT02291484)
- Testing
- Cardiac CT scan
- Where
- 4 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Erasmus Medical Center
Stable Angina Pectoris
Evaluation and Comparison of Several Point-of-care Platelet Function Tests in Predicting Clinical Outcomes in Clopidogrel Pre-treated Patients Undergoing Elective PCI.
The purpose of this study is to investigate whether the level of Platelet Inhibition as assessed with five point-of-care platelet function assays correlates with clinical (periprocedural) outcomes such as Acute Myocardial…
- Trial name
- NCT00352014
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- R&D Cardiologie
Stable Angina, Unstable Angina
Low Rate Fluoroscopy to Reduce Radiation Dose During Coronary Angiography and Intervention
Objectives: To determine the efficacy of low rate fluoroscopy at 7.5 frames per second (FPS) vs. conventional 15 FPS for reduction of operator and patient radiation dose during diagnostic coronary angiography and percutaneous…
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT01990924
- Testing
- 15 FPS, 7.5 FPS
- Where
- Canada
- Volunteers
- 385 people
- Sponsor
- Laval University
Stable Coronary Artery Disease (CAD), Myocardial Infarction
Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients
THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and…
- Trial name
- TIGRIS (NCT01866904)
- Where
- 309 sites in United States, Argentina and 23 more
- Volunteers
- 9,284 people
- Sponsor
- AstraZeneca
Microvascular Angina, Angina Pectoris
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected.
- Conditions
- Microvascular Angina, Angina Pectoris, Angina, Stable, Non-Obstructive Coronary Atherosclerosis
- Trial name
- CorCMR (NCT04805814)
- Testing
- CMR results disclosed, CMR performed but results not disclosed
- Where
- 3 sites in United Kingdom
- Volunteers
- 280 people
- Sponsor
- NHS National Waiting Times Centre Board
Chronic Stable Angina
Danhong Injection in the Treatment of Chronic Stable Angina
The purpose of this study is to evaluate the effect of Danhong Injection on the relief of angina with the use of the Seattle Angina Questionnaire among patients with stable angina patients
- Trial name
- NCT01681316
- Testing
- Danhong injection, Standard medical care
- Where
- 31 sites in China
- Volunteers
- 920 people
- Sponsor
- China Academy of Chinese Medical Sciences