Clinical trials: Stable Ischemic Heart Disease
Angina Pectoris, Stable
Effects of Ivabradine on Residual Myocardial Ischemia After PCI
This is a randomized pharmacological study evaluating the effects of ivabradine in patients with residual angina after PCI. The role of ivabradine in patients with angina, without systolic dysfunction, is not yet clear.
- Trial name
- NCT03866395
- Testing
- Ivabradine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Policlinico Umberto I
Arterial Hypertension, Diabetes Mellitus
Azilsartan Medoxomil in Hypertensive pAtients With Stable Ischemic Heart Disease and DiabEtes MEllitus.
One-center, observational, non-interventional, prospective study of the efficacy of azilsartan medoxomil in patients with arterial hypertension associated with stable ischemic heart disease and type 2 diabetes mellitus.
- Conditions
- Arterial Hypertension, Diabetes Mellitus, Stable Chronic Angina
- Trial name
- AcADEME (NCT03539627)
- Testing
- Azilsartan Medoxomil 40 MG Oral Tablet [Edarbi]
- Where
- Russia
- Volunteers
- 184 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Stable Angina Pectoris
Acupoint Application in Patients With Stable Angina Pectoris (AASAP)
Hypothesis: acupoint application is effective for managing chronic stable angina pectoris. Aim: to evaluate the efficacy and safety of acupoint application on the specific acupoints for chronic stable angina pectoris.
- Trial name
- AASAP (NCT02029118)
- Testing
- Herbal plaster ( styrax, borneol, frankincense, santalum,trichosanthes kirilowii Maxim, allium macrostemon Bunge, leech), acupoint, Aspirin: 100mg qd; Metoprolol：25mg bid; Ramipril:5mg qd; Atorvastatin:20mg qn.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Coronary Artery Disease, Stable Angina
Randomized Controlled Study of the Traditional Percutaneous Coronary Intervention and Intervention Using Optical Coherence Tomography of Incomplete Stent Adhesion and Extent of the Formation of Neointima by Resolute Zotarolimus-eluting Stent Insertion
Optical coherence tomography (OCT) after the stent procedure to improve the adhesion and expansion, or incomplete uncovered struts attached to the main track.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- NCT01869842
- Testing
- percutaneous coronary intervention, OCT-guided percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Yonsei University
Cardiovascular Diseases, Myocardial Infarction
Exercise as a Life-long Medicine in Patients With Coronary Artery Disease
Exercise training is a core component in cardiac rehabilitation. Exercise adherence is, however, low after rehabilitation and the transition from supervised to unsupervised exercise is problematic for many patients with coronary…
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Angina (Stable)
- Trial name
- NCT02228603
- Testing
- high-intensity exercise training, web-based follow-up program, usual care
- Where
- 2 sites in Norway
- Volunteers
- 161 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Disease
CT Calcium Scoring in Suspected Stable Angina
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals.
- Trial name
- NCT01660594
- Testing
- CT calcium scoring
- Where
- United Kingdom
- Volunteers
- 705 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Angina, Stable, Angina, Unstable
Atherosclerotic Lesion Proteomics by Harvesting Angioplasty Balloons (ALPHA).
The purpose of the study is to identify proteins, metabolites and signal pathways related directly to symptomatic atherosclerosis and to disease progression.
- Conditions
- Angina, Stable, Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT05319366
- Where
- 2 sites in Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease
Rosiglitazone and Metformin: Outcomes Trial in Nondiabetic Patients With Stable Coronary Syndromes (Romance) Pilot Study
Nearly half of all Americans will die from cardiovascular disease caused by the build up of atherosclerotic plaque within coronary arteries.
- Trial name
- NCT00343395
- Testing
- AVANDAMET
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Stable Angina, Unstable Angina, NSTEMI
Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease
This retrospective study will evaluate the coronary angiograms of approximately 100 patients who have undergone invasive angiography and fractional flow reserve (FFR).
- Trial name
- NCT06183294
- Testing
- Collecting invasive FFR measurements.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease, Atherosclerosis
Drug-eluting Balloon in Bifurcations Trial
The purpose of the DEBIUT study is to assess procedural, clinical and angiographic outcomes of: 1. Provisional T-stenting use for dilation the Paclitaxel-eluting PCI-balloon (DiorTM) in comparison to dilation with a standard…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Stable Angina, Unstable Angina
- Trial name
- DEBIUT (NCT00857441)
- Testing
- Drug eluting balloon, Liberté, PTCA balloon catheter
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Stable Angina, Coronary Disease
Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina
This study of 402 cases of stable angina subjects who were diagnosed as Coronary Heart Disease (CHD) is a randomized, blank controlled, multi-center clinical study.
- Trial name
- SIGMART (NCT01396395)
- Testing
- Nicorandil, Standard Treatment
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Coronary Arteriosclerosis, Endothelial Function
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
- Trial name
- NCT00534651
- Testing
- Paracetamol
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Atrial Fibrillation (AF), Coronary Artery Disease
Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation
The goal of this clinical trial is to learn whether the antiarrhythmic drug flecainide can be used as safely as standard rhythm-control drugs in people with atrial fibrillation (AF) and stable coronary artery disease (CAD).
- Trial name
- ReCAST AF (NCT07405671)
- Testing
- flecainide, Sotalol or Amiodarone
- Where
- 14 sites in Belgium
- Volunteers
- 988 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atherosclerosis
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated…
- Trial name
- CANTOS (NCT01327846)
- Testing
- Canakinumab, Standard of care
- Where
- 1,131 sites in United States, Argentina and 38 more
- Volunteers
- 10,066 people
- Sponsor
- Novartis Pharmaceuticals
Stable Coronary Disease, Unstable Coronary Disease
Brazilian and Italian Evaluation of Safety Using Tacrolimus-eluting Stent With Short-term Dual Antiplatelet Regimen
To evaluate the safety and efficacy of the Janus OPTIMA Tacrolimus-Eluting Stent (Optima TES, CID) for the treatment of de novo coronary lesions when associated with short-term (two months) dual antiplatelet (aspirin +…
- Conditions
- Stable Coronary Disease, Unstable Coronary Disease, Documented Silent Ischemia
- Trial name
- BEST (NCT01122719)
- Testing
- Drug Eluting Stent
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 16 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Clopidogrel/Aspirin Interaction Study
This study will explore the effect of different doses of aspirin on the effects of double-dose or standard dose clopidogrel.
- Trial name
- INTERACTION (NCT01102439)
- Testing
- Clopidogrel, Aspirin
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Population Health Research Institute
Chronic Kidney Disease, Stable Angina
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Impaired renal function is associated with reduced responsiveness to clopidogrel. There are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (CKD).
- Trial name
- CKD (NCT01328470)
- Testing
- Clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Kyunghee University Medical Center
Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions
A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values
In this randomised controlled trial of patients with stable angina and documented intermediate coronary disease with indeterminate or "grey-zone" Fractional Flow Reserve (FFR) we will randomise patients to either optimal medical…
- Conditions
- Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions, Stable Angina, Coronary Physiology
- Trial name
- GzFFR (NCT02425969)
- Testing
- PCI, Optimal Medical Therapy
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Golden Jubilee National Hospital
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University