Clinical trials: Stable Ischemic Heart Disease
Coronary Artery Disease
The INtegrilin Plus STenting to Avoid Myocardial Necrosis Trial (INSTANT)
Patients with stable coronary artery disease, undergoing PCI by means of implantation of >33 mm of DES, will be randomized single-blinded to eptifibatide plus unfractioned heparin according to the ESPRIT protocol vs placebo plus…
- Trial name
- INSTANT (NCT01454440)
- Testing
- Eptifibatide
- Where
- Italy
- Volunteers
- 91 people
- Sponsor
- University of Turin, Italy
Angina, Stable, Coronary Artery Disease
Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology
The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services.
- Trial name
- ORACLE (NCT06325020)
- Testing
- The assessment of patients with possible angina using the ORACLE pathway
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Stable Angina
Does Mean Platelet Volume Change With Clopidogrel
Platelets play a major role in thrombus formation and platelet size, measured by Mean Platelet Volume (MPV) correlates with platelet activity.
- Trial name
- NCT02550301
- Testing
- Mean Platelet Volume
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Stable Angina
CYP2C19 Gene Alteration and Thienopyridine Resistance in Percutaneous Coronary Intervention Study
Dual antiplatelet therapy with aspirin and thienopyridines decreases the rate of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- CALDERA-PCI (NCT00876512)
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Angina, Stable
- Trial name
- AF-INOCA (NCT05825339)
- Testing
- Coronary Flow Reserve
- Where
- 6 sites in Spain
- Volunteers
- 121 people
- Sponsor
- Spanish Society of Cardiology
Coronary Artery Disease, Coronary Heart Disease
Comparison of the Angiographic Result of the Orsiro Hybrid Stent With Resolute Integrity Stent
The purpose of this multicenter, randomized, open label, parallel arm study whether the newest 3rd generation stent - Orsiro hybrid sirolimus-eluting stent is noninferior to the newest 2nd generation stent - Resolute Integrity…
- Conditions
- Coronary Artery Disease, Coronary Heart Disease, Stable Angina, Unstable Angina
- Trial name
- ORIENT (NCT01826552)
- Testing
- Osiro Hybrid Drug-Eluting Stent, Resolute Integrity
- Where
- 8 sites in South Korea
- Volunteers
- 372 people
- Sponsor
- Seoul National University Bundang Hospital
Arterial Hypertension, CHD - Coronary Heart Disease
Assessment of the Efficacy and Tolerability of the Fixed-dose Combination of Bisoprolol/Perindopril
Study objective - to assess the efficacy, tolerability and adherence of bisoprolol/perindopril FDC in patients with HT and stable CAD in everyday practice.
- Trial name
- STYLE (NCT03730116)
- Testing
- bisoprolol/perindopril FDC
- Where
- Russia
- Volunteers
- 1,909 people
- Sponsor
- Servier Russia
Coronary Heart Disease, Stable Angina Pectoris
Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation
The objective of this study is a comparative evaluation of Orsiro stent and of Resolute Integrity stent in terms of the extent of neointima formation at 4 months after implantation using optical coherence tomography (OCT).
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- Healing (NCT04465669)
- Testing
- Orsiro stents, Resolute Integrity® stents
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Heart Disease
Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease
The purpose of this study is to determine whether Ateronon, a nutritional supplement that contains lycopene from tomatoes has a favorable effect on carotid atherosclerosis, lipid levels, and other biomarkers of coronary heart…
- Trial name
- NCT00939237
- Testing
- Ateronon
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2, Ischemic Heart Disease
Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor
Type 2 diabetes mellitus (type 2 DM) is an important disease with increasing prevalence worldwide. More than 60% of diabetes patients die of CVD.
- Trial name
- NCT03178591
- Testing
- vildagliptin, Dapagliflozin
- Where
- Thailand
- Volunteers
- 43 people
- Sponsor
- Chiang Mai University
Angina Pectoris, Coronary Artery Disease
Effects of Integrated Treatment by Traditional Chinese and Western Medicine in Reducing Cardiovascular Events
Compared with standardized western medical drug therapy, this study is mainly about whether the combination of standardized western medical drug therapy and Chinese medical continued treatment, can further decrease the rate of…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Coronary Disease, Heart Disease
- Trial name
- NCT01715376
- Where
- China
- Volunteers
- 1,042 people, healthy volunteers welcome
- Sponsor
- Changchun University of Chinese Medicine
Coronary Disease
Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI
Prolonging infusions may decrease myocardial damage associated with bivalirudin use during primary PCI. The investigators hypothesized that continuing the bivalirudin infusion commenced during the procedure at the PCI recommended…
- Trial name
- NCT02787317
- Testing
- bivalirudin, Heparin
- Where
- 2 sites in China
- Volunteers
- 1,770 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Stenoses, Stable Angina
e-BioMatrix 6 Month DAPT France
Prospective, multi-center observational study to be conducted in up to 30 French interventional cardiology centers. The purpose of this observational study is to capture, in French Centers, clinical data of the BioMatrix Flex™…
- Conditions
- Coronary Artery Stenoses, Stable Angina, Ischemia, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCT03461484
- Volunteers
- 2,098 people
- Sponsor
- Biosensors Europe SA
Coronary Artery Disease
F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow
Use of novel radio-pharmaceutical Rhodamine 6G to determine myocardial blood flow
- Trial name
- NCT04528758
- Testing
- Rhodamine 6G
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Stable Angina Pectoris, Unstable Angina Pectoris
Feasibility Study of Photopheresis Post Angioplasty
The primary objective of the study is to evaluate the difference in 6-month restenosis rates in coronary artery lesions treated by photopheresis in addition to angioplasty with stent placement, as opposed to no photopheresis…
- Conditions
- Stable Angina Pectoris, Unstable Angina Pectoris, Silent Ischemia
- Trial name
- NCT00157001
- Testing
- Photopheresis Post Angioplasty
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Atlantic Health System
Coronary Artery Disease
Clinical, Physiological and Prognostic Implication of Microvascular Status
There are several physiologic parameters in evaluating cardiovascular disease. This study will reveal which parameter is the most proper value in predicting disease severity and risk factors of patients.
- Trial name
- NCT02186093
- Where
- 5 sites in South Korea
- Volunteers
- 1,197 people
- Sponsor
- Seoul National University Hospital
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Coronary Artery Disease, Microcirculation
The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease
The study should enrol 50 patients with stable coronary artery disease scheduled for elective percutaneous coronary intervention of single, de novo lesion of native coronary artery.
- Conditions
- Coronary Artery Disease, Microcirculation, Vascular Resistance
- Trial name
- PATMOS (NCT02107144)
- Testing
- trimetazidine
- Where
- Serbia
- Volunteers
- 71 people
- Sponsor
- Clinical Hospital Center Zemun
Coronary Artery Disease, Stable Angina
The Effect Of Ticagrelor On Saphenous Vein Graft Patency In Patients Undergoing Coronary Artery Bypass Grafting Surgery
In the POPular CABG study we investigate if the addition of ticagrelor, a drug that inhibits blood platelets from clotting, to treatment with aspirin will reduce the rate of saphenous vein graft occlusion as assessed with…
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- POPular CABG (NCT02352402)
- Testing
- Ticagrelor
- Where
- 6 sites in Netherlands
- Volunteers
- 487 people
- Sponsor
- J.M. ten Berg
Hypertension, Chronic Stable Angina
Bioequivalency Study of Amlodipine Tablets Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Amlodipine Besylate tablets, 10 mg, to Norvasc® Tablets, 10 mg (Pfizer) under fed conditions using a single-dose, randomized, 2-treatment, 2-period…
- Conditions
- Hypertension, Chronic Stable Angina, Vasospastic Angina
- Trial name
- NCT00601302
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories