Clinical trials: Stage III
Tumor Lysis Syndrome
Febuxostat for Tumor Lysis Syndrome Prevention in Hematologic Malignancies
The purpose of this study is to determine whether febuxostat is superior to allopurinol in the prevention of tumor lysis syndrome (TLS) in patients with hematological malignancies at intermediate or high risk of TLS (according to…
- Trial name
- FLORENCE (NCT01724528)
- Testing
- Febuxostat, Allopurinol
- Volunteers
- 346 people
- Sponsor
- Menarini Group
Pancreatic Acinar Carcinoma, Pancreatic Neoplasms
Acelarin First Line Randomised Pancreatic Study
The primary purpose of this study is to assess whether Acelarin (NUC-1031) is superior to gemcitabine in terms of overall survival for treatment of patients with metastatic pancreatic carcinoma.
- Trial name
- ACELARATE (NCT03610100)
- Testing
- Acelarin, Gemcitabine
- Where
- United Kingdom
- Volunteers
- 328 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Secondary Hypogonadism
An Extension Study of Enclomiphene Citrate in the Treatment of Men With Secondary Hypogonadism
To determine the safety profile of Androxal in men with secondary hypogonadism.
- Trial name
- NCT01739582
- Testing
- Androxal
- Volunteers
- 300 people
- Sponsor
- Repros Therapeutics Inc.
Pancreatic Cancer
Fluorouracil, External-Beam Radiation Therapy, and Gemcitabine With or Without Brachytherapy Using Phosphorus P32 in Treating Patients With Locally or Regionally Advanced Unresectable Adenocarcinoma of the Pancreas
RATIONALE: Drugs used in chemotherapy, such as fluorouracil and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00079365
- Testing
- fluorouracil, gemcitabine hydrochloride, brachytherapy
- Where
- United States
- Sponsor
- University of South Florida
COVID-19
Study on the Safety and Efficacy of Meplazumab for Injection Patients COVID-19
This is a multicenter, randomized, double-blind, placebo-controlled, add-on Phase III clinical study. Based on the "Diagnosis and Treatment Protocol for COVID-19 Pneumonia (Trial 10th edition)" and according to the results of…
- Trial name
- NCT05679492
- Testing
- Meplazumab foe injection, Normal saline
- Where
- China
- Sponsor
- Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
Non-Small Cell Lung Cancer
A Study of the Efficacy and Safety of MetMAb Combined With Tarceva in Patients With Met-Positive Non-Small Cell Lung Cancer
This randomized, Phase III, double-blind, placebo-controlled study will evaluate the safety and efficacy of MetMAb (onartuzumab) in combination with Tarceva (erlotinib) compared with treatment with Tarceva alone in patients with…
- Trial name
- NCT02031744
- Testing
- erlotinib [Tarceva], Onartuzumab [MetMAb]
- Where
- 8 sites in China
- Volunteers
- 530 people
- Sponsor
- Hoffmann-La Roche
Hot Flashes, Prostate Cancer
Soy Protein/Effexor Hormone Therapy for Prostate Cancer
RATIONALE: Soy protein/isoflavones and venlafaxine may help relieve hot flashes in patients receiving hormone therapy for prostate cancer.
- Trial name
- NCT00354432
- Testing
- oral soy protein/isoflavones powder, Venlafaxine
- Where
- 20 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Knee Osteoarthritis (Knee OA)
Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis
This study is a randomized, double-blind, multicenter Phase II/III clinical trial designed to evaluate the effectiveness and safety of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome compared with sodium…
- Trial name
- SECRET-OA (NCT07337863)
- Testing
- UC-MSC-Derived Secretome, Sodium Hyaluronate (Hyalein)
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sriwijaya
Colorectal Cancer
Increasing Colorectal Cancer Screening Uptake With a Patient Navigator
Patients who receive tailored navigation (consisting of a letter and patient navigation services) and get screened will be significantly greater than the control group who receives treatment as usual.
- Trial name
- NCT01506687
- Testing
- Health counselling by nurse navigator, Usual primary care counselling
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Cancer Care Ontario
Pancreatic Cancer
Fluorouracil, Gemcitabine, and Radiation Therapy in Treating Patients With Cancer of the Pancreas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003216
- Testing
- fluorouracil, gemcitabine hydrochloride, radiation therapy
- Where
- 107 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- Radiation Therapy Oncology Group
Periodontal Bone Loss, Periodontitis Stage III
Treatment of Periodontal Intrabony Defects With Liquid Platelet-Rich Fibrin Mixed With Denaturated Albumin Gel (ALB_PRF)
The objective of study also is to assess radiographic linear defect depth, and radiographic defect bone density following the application of liquid Platelet-Rich Fibrin (PRF) mixed with denaturated Albumin gel (ALB-PRF) or with…
- Conditions
- Periodontal Bone Loss, Periodontitis Stage III, Intra-bony Pockets
- Trial name
- ALB-PRF (NCT06798116)
- Testing
- Experimental: open flap debridement and demineralized freeze-dried bone allograft and mixed with liquid (PRF, defects will be treated with open flap debridement and liquid (PRF) mixed with denatured albumin gel (ALB-PRF) will be injected in periodontal intrabony defects, defects will be treated with open flap debridement , DFDBA mixed with liquid (PRF) and collagen membrane
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Colorectal Cancer, Metastatic Cancer
Monoclonal Antibody Therapy in Treating Patients With Colorectal Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00005616
- Testing
- conventional surgery, neoadjuvant therapy, radionuclide imaging
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma
Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer
This phase Ib trial finds the best dose and side effects of ensartinib and its effects when given with carboplatin, pemetrexed and bevacizumab for in treating patients with ALK-positive non-small cell lung cancer that is stage…
- Conditions
- Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT04837716
- Testing
- Bevacizumab, Carboplatin, Ensartinib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Urinary Incontinence Stress
Open Label Phase III Duloxetine Study for Stress Urinary Incontinence
The purpose of this study is to monitor the long term safety of duloxetine in the treatment of stress urinary incontinence.
- Trial name
- NCT00191204
- Testing
- Duloxetine
- Where
- United Kingdom
- Volunteers
- 363 people
- Sponsor
- Eli Lilly and Company
Melanoma Stage Iii, Melanoma Stage Iv
Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma
This is a multicenter open-label, single-arm, phase II study designed to investigate the pharmacodynamic and antitumor effects of denosumab alone and in combination with an anti-Programmed death-1 or Programmed death ligand 1…
- Conditions
- Melanoma Stage Iii, Melanoma Stage Iv, Melanoma, Melanoma (Skin)
- Trial name
- NCT03620019
- Testing
- Denosumab, Pembrolizumab, Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lymphoma
Two Different Methods of Collecting Stem Cells For an Autologous Stem Cell Transplant in Treating Patients With Diffuse Large Cell Lymphoma
RATIONALE: It is not yet known which method of stem cell collection is best for patients undergoing an autologous stem cell transplant.
- Trial name
- NCT00566228
- Testing
- autologous hematopoietic stem cell transplantation, leukapheresis
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Mayo Clinic
Pain, Postoperative, Nerve Block
Use of Perioperative Pain Blocks In Urological Surgery
The study team aims to prospectively compare Placebo (local administration), ultrasound-guided transversus abdominis plane (UTAP) blocks, and laparoscopic-guided transversus abdominis plane (LTAP) blocks in patients undergoing…
- Conditions
- Pain, Postoperative, Nerve Block, Robotic Surgical Procedures
- Trial name
- NCT04426500
- Testing
- Bupivacain, Ultrasound-guided transversus abdominus plane block, Laparoscopic-guided transversus abdominus plane block
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteosarcoma
Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous Second-line Treatment Failure
This is a randomized, controlled, open, multicenter phase III clinical study to evaluate the efficacy and safety of HS-20093 for injection versus gemcitabine in combination with docetaxel in patients with osteosarcoma who have at…
- Trial name
- NCT06935409
- Testing
- HS-20093, Gemcitabine combined with docetaxel
- Where
- 2 sites in China
- Volunteers
- 122 people
- Sponsor
- Hansoh BioMedical R&D Company
Acute Myeloid Leukemia
Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation
Randomized Phase-III, two-arm, open-label, multi-center study in adult patients with AML and NPM1 mutation. Before Amendment No.
- Trial name
- NCT00893399
- Testing
- Gemtuzumab Ozogamicin (Mylotarg), standard chemotherapy
- Where
- 60 sites in Austria, Germany
- Volunteers
- 600 people
- Sponsor
- University of Ulm
Surgery, Liver Metastases
Improved Recovery by Iron Following Surgery With Blood Loss, the IRIS-trial
The aim of the study is to investigate if iv iron formulation improve recovery after surgery with blood loss. Post-operative anaemia is a common debilitating condition after major surgery due to a combination of preoperative iron…
- Conditions
- Surgery, Liver Metastases, Liver Cancer, Pancreas Cancer
- Trial name
- IRIS (NCT05744219)
- Testing
- Ferric carboxymaltose
- Where
- Sweden
- Volunteers
- 338 people
- Sponsor
- Jon Unosson
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.