Clinical trials: Staining
Tooth Stain Removal
Clinical Research Study to Evaluate the Stain Removal Efficacy
The objective of this clinical research study is to evaluate the stain removal efficacy of a toothpaste containing stannous fluoride as compared to negative control toothpaste in adults.
- Trial name
- NCT06242769
- Testing
- Stannous Fluoride Toothpaste (SnF), Colgate Fluoride Toothpaste (CDC)
- Where
- Puerto Rico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Oral Hygiene
A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices
The purpose of this study is to determine whether spherical silica can achieve similar or greater extrinsic dental stain and plaque removal, in comparison to dentifrices containing higher concentrations of standard abrasive…
- Trial name
- NCT03267511
- Testing
- 5% KNO3 / 0.2542% NaF dentifrice with 0.5% spherical silica, 5% KNO3 / 0.2542% NaF dentifrice with 1% spherical silica and 5% STP, 5% KNO3 / 0.2542% NaF dentifrice with 6% abrasive silica
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Pellicle
A Pilot Drug Trial That Evaluates the Whitening Potential of Nicotine Gum
The purpose of this research study is to evaluate the effects on existing tooth stain of nicotine gum. The study will enroll adults who have visible tooth staining.
- Trial name
- NCT00174499
- Testing
- 2 mg nicotine gum, 4 mg nicotine gum
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- McNeil AB
Dental Devices, Home Care
Two Week Cumulative Extrinsic Stain Removal of a Battery-powered Toothbrush and a Manual Toothbrush
To evaluate and compare the extrinsic stain removal efficacy of a battery-powered toothbrush and a manual toothbrush following two weeks of brushing.
- Trial name
- NCT06292611
- Testing
- Battery operated toothbrush, Manual toothbrush
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Cervical Intraepithelial Neoplasia Grade 2/3
The Study of Folate Receptor-Mediated Staining Solution (FRD™) In Cervical Lesion Detection
The FRDTM is easy to perform and does not require sophisticated laboratory technology and/or experienced pathologists for test result interpretation.
- Trial name
- NCT03366493
- Testing
- FRD, Cytology, HPV testing
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GY Highland Biotech LLC
Tooth Stain
A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
The whitening action of an investigative hydrogen peroxide/sodium fluoride containing mouth rinse will be evaluated through stain removal using mean Lobene Stain Index over 14 days compared to a currently marketed hydrogen…
- Trial name
- NCT02151058
- Testing
- Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Normal Healthy Eyes
Staining in a Healthy, Non-Dry Eye Population
The clinical objective of this study is to quantify the levels of corneal and conjunctival staining in a healthy, non-dry eye population. This is a descriptive study without test article administered.
- Trial name
- NCT00643942
- Testing
- No intervention required
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Oral Hygiene
An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
The aim of this study is to compare the stain effect on teeth of twice daily brushing with a 67% sodium bicarbonate containing toothpaste versus standard toothpaste (not containing sodium bicarbonate) for six weeks whilst using a…
- Trial name
- NCT01962493
- Testing
- Sodium bicarbonate/ Sodium Fluoride, Sodium fluoride, Chlorhexidine digluconate
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Discoloration
A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up
The aim of this clinical study is to evaluate the efficacy of an experimental mouthwash used with a marketed whitening toothpaste or a marketed regular fluoride toothpaste, compared to a marketed regular fluoride toothpaste…
- Trial name
- NCT07836998
- Testing
- Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- HALEON
Herpes Zoster
Month 30 & 42 Extension Studies of CRD-004 Primary Study
The safety and immunogenicity of the GSK324332A vaccine has been evaluated up to Month 12 post-vaccination in the primary study.
- Trial name
- NCT00492648
- Testing
- Blood sampling for assay of persistence of immunogenicity
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Disease Progression, Disease Severity
Topical Cyclosporine and Disease Progression
The purpose of this study is to evaluate the effect Restasis has in regards to disease progression.
- Conditions
- Disease Progression, Disease Severity, Staining, Schirmers
- Trial name
- NCT00567983
- Testing
- Restasis, Endura
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Corneal Staining
Short-Term Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions
An investigational multi-purpose solution (MPS)was clinically evaluated against Biotrue MPS at specific time points over the course of four days. The study was conducted with PureVision lenses.
- Trial name
- NCT01240122
- Testing
- Biotrue MPS, Investigational MPS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Staining
Clinical Study to Assess the Efficacy of Professional Tooth Whitening Maintenance System
Clinical study to assess the efficacy of professional tooth whitening maintenance system of a Colgate toothpaste containing 5% Hydrogen Peroxide with a stain-fighter mouthwash as compared to only the stainfighter mouthwash and a…
- Trial name
- NCT06613347
- Testing
- whitening maintenance, whitening maintenance MW, negative control
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Tooth Discoloration
Safety and Efficacy of the ToothWave Power Toothbrush for Extrinsic Stain Reduction
This study is a single blind, prospective study aimed to evaluate the safety and efficacy of the Silk'n ToothWave Power Toothbrush for stains reduction and improvement of teeth shade.
- Trial name
- NCT03885609
- Testing
- ToothWave, powered toothbrush
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Contact Lens Wear
Compliance and Contamination in Soft Contact Lens Wearers
The purpose of this study is to assess the lens and lens case microbial colonization associated with marketed care solutions used by experienced soft lens wearers.
- Trial name
- NCT01069237
- Testing
- OPTI-FREE RepleniSH, Clear Care
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Visual Acuity, Slit Lamp Biomicroscopy (Corneal Staining Assessment)
Clinical Evaluation of 3 Contact Lens Materials With 3 Solution Types
This is a multi-site, randomized, double-masked, contralateral, 2 treatment x 2 period crossover, dispensing, five-visit study to gain clinical insights of the study lenses and solutions.
- Trial name
- NCT03466060
- Testing
- Opti-Free : RevitaLens / Clear Care : RevitaLens, Opti-Free : RevitaLens / RevitaLens : Clear Care, Clear Care : RevitaLens/ Opti-Free : RevitaLens
- Where
- 5 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Teeth Staining
The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use.
The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic…
- Trial name
- NCT07219342
- Testing
- Toothpaste
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Boka LLC
Teeth Staining
The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use.
The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic…
- Trial name
- NCT07761715
- Testing
- Toothpaste
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Boka LLC
Tooth Discoloration
Efficacy of Manual Toothbrushes in Removing Tooth Stains
Efficacy of Manual Toothbrushes in Removing Tooth Stains: A 6-Week Clinical Research Study.
- Trial name
- NCT06486974
- Testing
- NaF, Na MFP
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Corneal Staining
A Clinical Comparison of Marketed Lens Care Solutions With Avaira Lens Brand
This study is a clinical comparison of the biocompatibility of several multipurpose solutions, Renu Fresh, Optifree Replenish, and ClearCare, and saline as a control solution among adapted hydrogel contact lens wearers wearing…
- Trial name
- NCT01335750
- Testing
- Multipurpose Solution #1, Multipurpose Solution #2, Mutlipurpose Solution #3
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.