Clinical trials: Standard Therapy
HIV Infections, Tuberculosis
Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
Anti-HIV treatment consisting of lamivudine/zidovudine (3TC/ZDV) and efavirenz (EFV) is the current standard of care for initial treatment of HIV in most areas of the world.
- Trial name
- NCT00120510
- Testing
- Efavirenz, Lamivudine/Zidovudine
- Where
- Haiti
- Volunteers
- 816 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis C
Valopicitabine Alone and Together With Pegylated Interferon in Patients With Chronic Hepatitis C Who Have Failed to Respond to Standard Therapy
This study is being conducted to compare the safety, effectiveness and tolerance of valopicitabine (NM283) when used alone and when valopicitabine is used together with pegylated interferon in hepatitis C treatment failure…
- Trial name
- NCT00120861
- Testing
- valopicitabine, pegylated interferon, ribavirin
- Where
- 11 sites in United States
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
WAND Study - A Study to Evaluate Fuzeon (Enfuvirtide) Administered by a Needle-Free Injection Device in Patients With HIV.
The purpose of this study is to evaluate the tolerability of a subcutaneous needle-free injection device used to administer Fuzeon, compared with the standard needle/syringe supplied with commercial Fuzeon.
- Trial name
- NCT00233883
- Testing
- enfuvirtide [Fuzeon]
- Where
- 17 sites in United States
- Volunteers
- 58 people
- Sponsor
- Hoffmann-La Roche
Cancer
Augmented Whole-body Scanning Via Magnifying PET/CT (AWSM-PET/CT) Techniques Abilities to Improve Upon the Diagnostic Accuracy of the Standard-of-care (SOC) PET/CT for Malignant Lesion Detection
Fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) has been demonstrated to outperform other imaging modalities such as CT and magnetic resonance imaging (MRI) for the detection of metastatic…
- Trial name
- NCT05513027
- Testing
- Augmented Whole-body Scanning via Magnifying PET, PET/CT
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Washington University School of Medicine
Lung Diseases, Lung Neoplasms
Observational Bronchoscopy Video Data Collection Study With Adult Patients
The primary aim is to develop a software algorithm that has the capacity to detect the normal 18 anatomical structures of the lung by using the position of the scope during the bronchoscopy procedure and using existing…
- Conditions
- Lung Diseases, Lung Neoplasms, Lung Cancer, Lung Transplantation
- Trial name
- NCT06465797
- Testing
- Bronchoscopy
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- Ambu A/S
Unresectable Colorectal Cancer
The Study of ONO-7913, ONO-4538 and the Standard of Care as First-line Treatment in Patients Colorectal Cancer
To confirm the tolerability and safety of combined administration of ONO-7913, ONO-4538 and the standard of care FOLFOX in combination with bevacizumab or cetuximab as first-line treatment in patients with unresectable advanced…
- Trial name
- NCT06540261
- Testing
- ONO-7913, ONO-4538, Fluorouracil
- Where
- 17 sites in Japan
- Volunteers
- 65 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Lung Diseases, Interstitial
A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)
This study is open to children and adolescents with interstitial lung disease (ILD) that causes lung fibrosis. This is a study for people who took part in a previous study called InPedILD (study 1199-0337) and for people who are…
- Trial name
- NCT05285982
- Testing
- Nintedanib (Ofev®)
- Where
- 28 sites in United States, Argentina and 15 more
- Volunteers
- 54 people
- Sponsor
- Boehringer Ingelheim
Female Infertility Due to Diminished Ovarian Reserve
Use of Dehydroepiandrosterone (DHEA) in Women With Normal and Poor Ovarian Reserve Undergoing IVF
The aim of the study is to evaluate the effect of DHEA supplement on ovarian reserve markers, ovarian response to gonadotrophins and cycle outcomes in patients with normal and poor ovarian reserve. Study Hypotheses: 1.
- Trial name
- NCT01915186
- Testing
- Dihydroepiandrosterone (DHEA)
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Carpal Tunnel Syndrome
Carpal Tunnel Syndrome Release Using PSU Retractor
The investigators study aims to evaluate both efficacy and safety of carpal tunnel release using limited incision with the PSU retractor compared to standard incision.
- Trial name
- NCT01017471
- Testing
- Limited incision using PSU retractor
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Prince of Songkla University
Periodontal Disease
Periodontal Follow-up and Glycemy in Patients With Type 2 Diabetes
Diabetes is a disease in which the majority of these patients have type 2 diabetes, linked to poor use of insulin by the body. Periodontitis is a chronic disease characterized by an immuno-inflammatory reaction with local…
- Trial name
- GlyCoSup (NCT07165171)
- Testing
- Innovative periodontal monitoring (SuP innovative)
- Where
- 8 sites in France
- Volunteers
- 516 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Heart Failure Preserved Ejection Fraction
Exercise, Mediterranean Diet and Inflammation in Heart Failure
This randomized clinical trial will test whether a multimodal anti-inflammatory program added to standard treatment improves the prognosis of patients with heart failure who have recently been hospitalized or visited the…
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Heart Failure, Diastolic (HFpEF), Chronic Inflammation
- Trial name
- FLARE-HF (NCT07885514)
- Testing
- Structured exercise training program, Mediterranean diet counseling, Standard heart failure management
- Volunteers
- 214 people
- Sponsor
- Hospital Severo Ochoa
Cancer/Squamous Cell Carcinoma of Skin
Comparative Efficacy of Cemiplimab to Historical Standard of Care in France
Primary Objective: -Assess the effectiveness of cemiplimab versus other available systemic therapies in patients up to 2018 or say historical system organ class (SOC) with metastatic or locally advanced cutaneous Squamous Cell…
- Trial name
- TOSCA (NCT05302297)
- Testing
- Cemiplimab
- Where
- France
- Volunteers
- 305 people
- Sponsor
- Sanofi
Arterial Disease of Legs, Below-the-knee Obstruction
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
This is a Pivotal, Prospective, randomized, two arm, placebo controlled, single-blind, multicenter trial that will be conducted at approximately 80 sites; approx.
- Conditions
- Arterial Disease of Legs, Below-the-knee Obstruction, PAD - Peripheral Arterial Disease
- Trial name
- MAGICAL BTK (NCT06182397)
- Testing
- MagicTouch PTA Sirolimus drug coated balloon
- Where
- 29 sites in United States
- Volunteers
- 368 people
- Sponsor
- Concept Medical Inc.
Malnutrition
The RELISH Study: Compliance and Palatability of Oral Nutritional Supplements in Hospitalised Older Adults
The RELISH study will investigate a new oral nutritional supplement (fortified porridge) for older adults in hospital who are undernourished (i.e., have malnutrition).
- Trial name
- NCT05620082
- Testing
- Standard liquid-based oral nutritional supplement, Fortified porridge
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Non-variceal Upper GI-bleeding With High Risk of Recurrency - OTSC (Over-the-scope-clip) Versus Standard Therapy (STING2)
Prospective-randomized multi-center trial. Patients with high risk of recurrent GI-bleeding (non-variceal) are identified and randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard…
- Trial name
- STING2 (NCT03331224)
- Testing
- OTSC, Endoscopic Standard therapy (combining two methods)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Diffuse Large B Cell Lymphoma (DLBCL)
A Study of Glofitamab Plus GemOx Compared With Standard of Care in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
The purpose of this study is to evaluate the efficacy and safety of glofitamab in combination with gemcitabine plus oxaliplatin (GemOx) versus standard of care (SOC) in patients with relapsed/refractory diffuse large B-cell…
- Trial name
- NCT07599423
- Testing
- Obinutuzumab, Glofitamab, Gemcitabine
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Hemorrhagic Shock
Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield, in civilian life, or which can be used during initial resuscitation in the first fixed facility…
- Trial name
- NCT01239680
- Testing
- Glutamine, Ringer's Lactate
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Missouri, Kansas City
Asthma
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
This study aimed to determine the efficacy and safety of QAW039 and QAW039 450 mg compared to placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016) in the…
- Trial name
- NCT02563067
- Testing
- QAW039
- Where
- 163 sites in United States, Argentina and 17 more
- Volunteers
- 877 people
- Sponsor
- Novartis Pharmaceuticals
Small Cell Lung Cancer Extensive Stage, Merkel Cell Carcinoma
Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 )
This study aims to determine safety, tolerability, recommended phase 2 dose (RP2D), and preliminary antitumor activity of 225Ac-SSO110 with standard of care (SoC) therapy in patients with somatostatin receptor 2 expressing…
- Trial name
- SANTANA-225 (NCT06939036)
- Testing
- 225Ac-SSO110 + SoC, Atezolizumab, Durvalumab
- Where
- 7 sites in United States, Australia
- Volunteers
- 2 people
- Sponsor
- Ariceum Therapeutics GmbH
Advanced Non-small Cell Lung Cancer
Abivertinib Maleate Versus Geifitinib in Patients With Advanced Non-small Cell Lung Cancer With Sensitive EGFR Mutation
To compare efficacy and safety of Abivertinib maleate alone versus standard first-line EGFR-TKIs for the treatment of patients with advanced non-small cell lung cancer with sensitive EGFR mutation
- Trial name
- NCT03856697
- Testing
- Abivertinib Maleate Capsules, Gefitinib Tablets
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Hangzhou ACEA Pharmaceutical Research Co., Ltd.
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