Clinical trials: Standard Therapy
Hepatitis C, Chronic
To Study the Efficacy and Safety of Renessans in Chronic HCV Patients
Chronic HCV infection is one of the common causes of the chronic liver disease. Approximately 6-10% of the general public is expected to be suffering from this infection.
- Trial name
- NCT01463592
- Testing
- RENESSANS , INTERFERON ALPHA 2b, Ribavirin, Interferon Alfa-2b AND RIBAVIRIN, RENESSANS
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- MTI Medical Private Limited, Pakistan
Breast Cancer
Phase 3 Trial of Elacestrant Versus Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
This Phase 3 clinical study compares the efficacy and safety of elacestrant to the standard of care (SoC) options of fulvestrant or an aromatase inhibitor (AI) in women and men with breast cancer whose disease has advanced on at…
- Trial name
- EMERALD (NCT03778931)
- Testing
- Elacestrant, Standard of Care
- Where
- 244 sites in United States, Argentina and 15 more
- Volunteers
- 478 people
- Sponsor
- Stemline Therapeutics, Inc.
Hepatitis, Autoimmune, Primary Biliary Cholangitis
Mycophenolate Mofetil Versus Cyclosporin A in the Treatment of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Due to Nonresponse to Standard Therapy
Biochemical response of primary biliary cholangitis-autoimmune hepatitis overlap syndrome induced by mycophenolate mofetil versus cyclosporin A
- Conditions
- Hepatitis, Autoimmune, Primary Biliary Cholangitis, Immunosuppression
- Trial name
- NCT04376528
- Testing
- Cyclosporin A, Mycophenolate Mofetil
- Where
- China
- Volunteers
- 89 people
- Sponsor
- West China Hospital
Prostate Cancer
Assessment of VMCore Biopsy Versus Standard of Care Biopsy
Prostate biopsy is the definitive test to establish the diagnosis of prostate cancer. The standard of care biopsy needles do not predictably obtain full cores of tissue and what tissue obtained is often fragmented, making…
- Trial name
- NCT04982536
- Testing
- VMCore Biopsy System, Standard of Care Biopsy Needle
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Uro-1 Medical
Acute on Chronic Liver Failure, HBV
A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study)
The AARC China Study is to establish a widely recognized and harmonized standard of patients with HBV-ACLF in the Asia Pacific region.
- Trial name
- NCT04054037
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Qin Ning
Asthma
MONO: Symbicort® Single Inhaler Therapy and Conventional Best Standard Treatment for the Treatment of Persistent Asthma in Adolescents and Adults
The purpose of the study is to compare the efficacy of a flexible dose of Symbicort (budesonide/formoterol) with conventional stepwise best standard treatment in patients with persistent asthma.
- Trial name
- NCT00242411
- Testing
- Budesonide/Formoterol Turbuhaler, Conventional Best Asthma Therapy
- Where
- 179 sites in Denmark, Finland and 1 more
- Volunteers
- 1,900 people
- Sponsor
- AstraZeneca
Obesity, Overweight
Improving Self-Monitoring in Weight Loss With Technology
We propose to conduct a randomized study of standard behavioral weight-loss treatment to test if using an electronic diary with or without tailored feedback will improve adherence to self-monitoring and subsequently improve…
- Trial name
- NCT00277771
- Testing
- Standard behavioral treatment (SBT) for weight loss, SBT for weight loss using a PDA, SBT for weight loss using a PDA with feedback messages
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Lora Burke
Colorectal Cancer
A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )
This study is to assess the sensitivity and added benefits of CADEYE compared to standard care (white-light) in detecting colon polyps in patients undergoing colonoscopy.
- Trial name
- NCT05523271
- Testing
- CAD EYE (Computer Aided Diagnosis ----?
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
The goal of this clinical study is to learn more about the study drug sacituzumab govitecan (SG; Trodelvy®; GS-0132; IMMU 132), versus standard of care (SOC) in participants with previously treated extensive stage small cell lung…
- Trial name
- EVOKE-SCLC-04 (NCT06801834)
- Testing
- Sacituzumab Govitecan (SG), Topotecan, Amrubicin (Japan only)
- Where
- 219 sites in United States, Argentina and 21 more
- Volunteers
- 695 people
- Sponsor
- Gilead Sciences
Chronic Myeloid Leukemia
Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy
This is an extension of our ongoing clinical trial using ex vivo expanded autologous Cytokine-induced killer (CIK) cells as an adoptive cellular immunotherapy for haematological malignancies.
- Trial name
- NCT00815321
- Testing
- Autologous CIK cell infusion
- Where
- Singapore
- Volunteers
- 11 people
- Sponsor
- Singapore General Hospital
Pregnancy Related, Narcotic Use
Determining the Effect of an "Alternate Recovery Protocol" Versus Current Standard of Care After Cesarean Section
This randomized controlled trial will compare two different approaches to patient recovery after cesarean section: the current standard of care versus an alternate management protocol.
- Trial name
- NCT03330119
- Testing
- Alternate Management, Control
- Where
- United States
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- Brest, Norman A., M.D.
Gastrointestinal Cancer
A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastrointestinal Cancer (Excluding Biliary Tract Cancer) Patients With FGFR Alterations Who Have Failed Standard Therapy
This study is a prospective single-arm phase II clinical study. Advanced Gastrointestinal cancer (excluding Biliary Tract Cancer) patients with FGFR 1-3 alterations who have failed standard therapy will be enrolled in this study…
- Trial name
- NCT05559775
- Testing
- Pemigatinib Pill
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang Cancer Hospital
Glioblastoma Multiforme, Glioblastoma
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
This will be a prospective, randomized, standard of care (SoC) controlled, parallel, open-label, multicenter pivotal study to investigate the efficacy and safety of Bevacizumab (BEV) in combination with or without microbubble…
- Conditions
- Glioblastoma Multiforme, Glioblastoma, Glioblastoma Multiforme, Adult, Glioma
- Trial name
- NCT06496971
- Testing
- Bevacizumab, Microbubble, Low-Intensity Focused Ultrasound
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- NaviFUS Corporation
Solid Tumor, Solid Tumor, Adult
Sargramostim With Ipilimumab Containing Therapy in Patients With Solid Tumors
This open label, randomized study will evaluate safety and tolerability of sargramostim when combined with an ipilimumab-containing regimen received as part of standard of care therapy.
- Trial name
- SALIENT (NCT05284214)
- Testing
- Sargramostim, Ipilimumab-containing therapy
- Where
- United States
- Sponsor
- Partner Therapeutics, Inc.
Carcinoma, Non-Small-Cell Lung
TAilored Post-Surgical Therapy in Early Stage NSCLC
Our hypothesis is that patients receiving therapy based on their baseline tumor ERCC1 levels and EGFR mutations would attain better disease free survival rates than patients in the control arm receiving noncustomized therapy.
- Trial name
- TASTE (NCT00775385)
- Testing
- Standard Chemotherapy, Customized Treatment
- Where
- 42 sites in France
- Volunteers
- 152 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Breast Neoplasms
Magnetic Resonance Imaging (MRI) Correlation to Standard of Care Imaging and Pathology Correlation in Breast Carcinoma
Magnetic Resonance Imaging (MRI) is a well known imaging tool for the investigation and diagnosis of breast cancer, used in addition to breast mammograms and ultrasound.
- Trial name
- NCT00291304
- Testing
- MRI
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- AHS Cancer Control Alberta
Breastcancer
A Comparative Study Between Oncoplastic Breast Surgery and Standard Conservative Surgery:Margin Status and Patient Satisfaction
This non randomized study is a comparative study between standard conservative breast surgery and oncoplastic surgery as regard margin status and patient satisfaction.
- Trial name
- NCT03012152
- Testing
- Standard conservative breast surgery, Oncoplastic breast surgery
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Standard Opioid Analgesic Treatment of Cancer-related Chronic Pain.
Efficacy and Safety of FITpatch Compared to Standard Opioid Treatment in Cancer Pain (FT-015-IN)
Primary objectives: To determine non-inferiority of FITpatch with regard to efficacy compared to standard opioid treatment To assess the safety of FITpatch compared to standard opioid treatment Secondary objectives: To assess the…
- Trial name
- NCT00279344
- Testing
- Fentanyl (Matrifen)
- Volunteers
- 220 people
- Sponsor
- Nycomed
Helicobacter Infections
A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection
The proposed study will test the hypothesis that H. pylori can be eradicated successfully (>85%) using half-or full-dose "concomitant" non-bismuth quadruple therapy regimen: rabeprazole, amoxicillin, clarithromycin and…
- Trial name
- NCT01219764
- Testing
- Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- American University of Beirut Medical Center
Chronic Myeloid Leukemia
Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy
Standard therapy with Imatinib (IM) significantly prolongs the survival of Ph+CML patients who obtain a complete cytogenetic response (CCgR).
- Trial name
- INTERIM0407 (NCT00858806)
- Testing
- Imatinib
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Università degli Studi di Brescia
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